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OpenBU

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  • Kiel, Douglas P; Demissie, Serkalem; Dupuis, Josée; Lunetta, Kathryn L; Murabito, Joanne M; Karasik, David (BioMed Central, 2007-9-19)
    BACKGROUND: Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits ...
  • Meigs, James B; Manning, Alisa K; Fox, Caroline S; Florez, Jose C; Liu, Chunyu; Cupples, L Adrienne; Dupuis, Josée (BioMed Central, 2007-9-19)
    BACKGROUND: Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants. METHODS: We used the ...
  • Benjamin, Emelia J; Dupuis, Josée; Larson, Martin G; Lunetta, Kathryn L; Booth, Sarah L; Govindaraju, Diddahally R; Kathiresan, Sekar; Keaney, John F; Keyes, Michelle J; Lin, Jing-Ping; Meigs, James B; Robins, Sander J; Rong, Jian; Schnabel, Renate; Vita, Joseph A; Wang, Thomas J; Wilson, Peter WF; Wolf, Philip A; Vasan, Ramachandran S (BioMed Central, 2007-9-19)
    BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provide ...
  • Ma, Qianli; Yu, Yi; Meng, Yan; Farrell, John; Farrer, Lindsay A; Wilcox, Marsha A (BioMed Central, 2005-12-30)
    Both theoretical and applied studies have proven that the utility of single nucleotide polymorphism (SNP) markers in linkage analysis is more powerful and cost-effective than current microsatellite marker assays. Here we ...
  • Lin, Jing-Ping; Zheng, Gang; Joo, Jungnam; Cupples, L. Adrienne (SAGE-Hindawi Access to Research, 2010-09-01)
    Serum lactate dehydrogenase (LDH) is used in diagnosing many diseases and is significantly determined by genetic factors. Three genes coding for LDH isoenzymes were mapped to chromosome 11q15 and 12p12. We used 330 Framingham ...
  • Linghu, Bolan; Snitkin, Evan S; Hu, Zhenjun; Xia, Yu; DeLisi, Charles (BioMed Central, 2009-09-03)
    An evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes. We integrate 16 genomic features to construct an ...
  • Wyszynski, Diego F; Panhuysen, Carolien I; Ma, Qianli; Yip, Agustin G; Wilcox, Marsha; Erlich, Porat; Farrer, Lindsay A (BioMed Central, 2003-12-31)
    BACKGROUND. To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected ...
  • Li, Jian-Liang; Hayden, Michael R; Warby, Simon C; Durr, Alexandra; Morrison, Patrick J; Nance, Martha; Ross, Christopher A; Margolis, Russell L; Rosenblatt, Adam; Squitieri, Ferdinando; Frati, Luigi; Gómez-Tortosa, Estrella; García, Carmen Ayuso; Suchowersky, Oksana; Klimek, Mary Lou; Trent, Ronald JA; McCusker, Elizabeth; Novelletto, Andrea; Frontali, Marina; Paulsen, Jane S; Jones, Randi; Ashizawa, Tetsuo; Lazzarini, Alice; Wheeler, Vanessa C; Prakash, Ranjana; Xu, Gang; Djoussé, Luc; Mysore, Jayalakshmi Srinidhi; Gillis, Tammy; Hakky, Michael; Cupples, L Adrienne; Saint-Hilaire, Marie H; Cha, Jang-Ho J; Hersch, Steven M; Penney, John B; Harrison, Madaline B; Perlman, Susan L; Zanko, Andrea; Abramson, Ruth K; Lechich, Anthony J; Duckett, Ayana; Marder, Karen; Conneally, P Michael; Gusella, James F; MacDonald, Marcy E; Myers, Richard H (BioMed Central, 2006-8-17)
    BACKGROUND: Age at onset of Huntington's disease (HD) is correlated with the size of the abnormal CAG repeat expansion in the HD gene; however, several studies have indicated that other genetic factors also contribute to ...
  • Ku, Manching; Koche, Richard P.; Rheinbay, Esther; Mendenhall, Eric M.; Endoh, Mitsuhiro; Mikkelsen, Tarjei S.; Presser, Aviva; Nusbaum, Chad; Xie, Xiaohui; Chi, Andrew S.; Adli, Mazhar; Kasif, Simon; Ptaszek, Leon M.; Cowan, Chad A.; Lander, Eric S.; Koseki, Haruhiko; Bernstein, Bradley E. (Public Library of Science, 2008-10-31)
    In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 ...
  • Latourelle, Jeanne C; Pankratz, Nathan; Dumitriu, Alexandra; Wilk, Jemma B; Goldwurm, Stefano; Pezzoli, Gianni; Mariani, Claudio B; DeStefano, Anita L; Halter, Cheryl; Gusella, James F; Nichols, William C; Myers, Richard H; Foroud, Tatiana (BioMed Central, 2009-9-22)
    BACKGROUND: Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age ...
  • Zheng, Yu; Roberts, Richard J; Kasif, Simon (BioMed Central, 2002-10-10)
    The current speed of sequencing already exceeds the capability of annotation. A new method for functional annotation is proposed using the conservation patterns of gene clusters and has been applied to the genome of ...
  • Vieira, Verónica M; Howard, Gregory J; Gallagher, Lisa G; Fletcher, Tony (BioMed Central, 2010-4-21)
    BACKGROUND: Location is often an important component of exposure assessment, and positional errors in geocoding may result in exposure misclassification. In rural areas, successful geocoding to a street address is limited ...
  • Kenerson, Margaret (Boston University, 1939)
  • Flaherty, Mary Elizabeth (Boston University, 1950)
    Mexico has proven to be a land of great variety; both in population and resources. This variation could, if properly directed, build a unified country from the present, badly disected country. The study just concluded ...
  • Bennitt, Rudolf (Boston University, 1921)
  • Waxer, Stephen J (Boston University, 1957)
    One of the most specialized methods of land use known to modern industry are Industrial Parks. In the strict sense of the term they are "tracts of land which are subdivided and developed according to a comprehensive plan ...
  • Lavery, Joseph Robert (Boston University, 1955)
  • Singh, Rena Shakuntala (Boston University, 1948)
  • Douglas, Melvin Henry (Boston University, 1955)
    The "Geography of Industry in the U.S.S.R." deals with the geographic distribution, the present structure and productive capacity, and the future potential of Soviet heavy industry. Each industry is treated separately, and ...
  • Ronan, John Henry (Boston University, 1955)
    The City of Newburyport is located 37 miles north of Boston in the extreme northeastern corner of Massachusetts. It has a population of 14,000 and is one of the oldest cities in the United States. Newburyport was originally ...