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Browsing Department of Biostatistics by Title

OpenBU

Browsing Department of Biostatistics by Title

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  • Pou, Karla M.; Massaro, Joseph M.; Hoffmann, Udo; Lieb, Kathrin; Vasan, Ramachandran S.; O'Donnell, Christopher J.; Fox, Caroline S. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: The prevalence of abdominal obesity exceeds that of general obesity. We sought to determine the prevalence of abdominal subcutaneous and visceral obesity and to characterize the different patterns of fat ...
  • Liu, Ching-Ti; Yuan, Shinsheng; Li, Ker-Chau (Nucleic Acids Research, 2009-2)
    Many successful functional studies by gene expression profiling in the literature have led to the perception that profile similarity is likely to imply functional association. But how true is the converse of the above ...
  • Blood, Emily A; Cabral, Howard; Heeren, Timothy; Cheng, Debbie M (BioMed Central, 2010-2-19)
    BACKGROUND: Linear mixed effects models (LMMs) are a common approach for analyzing longitudinal data in a variety of settings. Although LMMs may be applied to complex data structures, such as settings where mediators are ...
  • Meng, Yan A; Yu, Yi; Cupples, L Adrienne; Farrer, Lindsay A; Lunetta, Kathryn L (BioMed Central, 2009-3-5)
    BACKGROUND. Single nucleotide polymorphisms (SNPs) may be correlated due to linkage disequilibrium (LD). Association studies look for both direct and indirect associations with disease loci. In a Random Forest (RF) analysis, ...
  • Montez-Rath, Maria; Christiansen, Cindy L; Ettner, Susan L; Loveland, Susan; Rosen, Amy K (BioMed Central, 2006-10-26)
    BACKGROUND: Providers use risk-adjustment systems to help manage healthcare costs. Typically, ordinary least squares (OLS) models on either untransformed or log-transformed cost are used. We examine the predictive ability ...
  • Lieb, Wolfgang; Sullivan, Lisa M.; Harris, Tamara B.; Roubenoff, Ronenn; Benjamin, Emelia J.; Levy, Daniel; Fox, Caroline S.; Wang, Thomas J.; Wilson, Peter W.; Kannel, William B.; Vasan, Ramachandran S. (American Diabetes Association, 2008-12-29)
    OBJECTIVE: Obesity predisposes individuals to congestive heart failure (CHF) and cardiovascular disease (CVD). Leptin regulates energy homeostasis, is elevated in obesity, and influences ventricular and vascular remodeling. ...
  • Sebastiani, Paola; Hartley, Stephen (2012-11-16)
    The program PleioGRiP performs a genome-wide Bayesian model search to identify SNPs associated with a discrete phenotype, and uses SNPs ranked by Bayes factor to produce nested Bayesian classifiers. These classifiers can ...
  • Corbett, Kelly L.; Losina, Elena; Nti, Akosua A.; Prokopetz, Julian J. Z.; Katz, Jeffrey N. (Public Library of Science, 2010-10-20)
    BACKGROUND. Most research on failure leading to revision total hip arthroplasty (THA) is reported from single centers. We searched PubMed between January 2000 and August 2010 to identify population- or community-based ...
  • Yang, Qiong; Cui, Jing; Chazaro, Irmarie; Cupples, L Adrienne; Demissie, Serkalem (BioMed Central, 2005-12-30)
    In genome-wide genetic studies with a large number of markers, balancing the type I error rate and power is a challenging issue. Recently proposed false discovery rate (FDR) approaches are promising solutions to this ...
  • Young, Robin L; Weinberg, Janice; Vieira, Verónica; Ozonoff, Al; Webster, Thomas F (2010-7-19)
    BACKGROUND. A common, important problem in spatial epidemiology is measuring and identifying variation in disease risk across a study region. In application of statistical methods, the problem has two parts. First, spatial ...
  • Aschengrau, Ann; Weinberg, Janice; Rogers, Sarah; Gallagher, Lisa; Winter, Michael; Vieira, Veronica; Webster, Thomas; Ozonoff, David (National Institute of Environmental Health Sciences, 2008-06)
    BACKGROUND. Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES. In this retrospective cohort study we examined ...
  • Aschengrau, Ann; Weinberg, Janice M; Janulewicz, Patricia A; Gallagher, Lisa G; Winter, Michael R; Vieira, Veronica M; Webster, Thomas F; Ozonoff, David M (BioMed Central, 2009-9-24)
    BACKGROUND: Prior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (PCE) have shown increases in the risk of certain congenital anomalies among exposed offspring. OBJECTIVES: This ...
  • Peloso, Gina M; Timofeev, Nadia; Lunetta, Kathryn L (BioMed Central, 2009-12-15)
    Population structure occurs when a sample is composed of individuals with different ancestries and can result in excess type I error in genome-wide association studies. Genome-wide principal-component analysis (PCA) has ...
  • Jalisi, Scharukh; Ainsworth, Tiffiny; LaValley, Michael (SAGE-Hindawi Access to Research, 2010-7-26)
    Objective. To evaluate the prognosis of tall cell variant (TCV) compared to usual variant (UV) papillary thyroid cancer by comparing disease-related mortality and recurrence data from published studies. Methods. Ovid MEDLINE ...
  • Arbelaez, Christian; Block, Brian; Losina, Elena; Wright, Elizabeth A.; Reichmann, William M.; Mikulinsky, Regina; Solomon, Jessica D.; Dooley, Matthew M.; Walensky, Rochelle P. (Springer-Verlag, 2009-9-1)
    BACKGROUND. The US Centers for Disease Control and Prevention (CDC) guidelines and the World Health Organization (WHO) both recommend HIV testing in health-care settings. However, neither organization provides prescriptive ...
  • Beane, Jennifer; Sebastiani, Paola; Liu, Gang; Brody, Jerome S; Lenburg, Marc E; Spira, Avrum (BioMed Central, 2007-09-25)
    Oligonucleotide microarray analysis revealed 175 genes that are differentially expressed in large airway epithelial cells of people who currently smoke compared with those who never smoked, with 28 classified as irreversible, ...
  • Latourelle, Jeanne C; Dybdahl, Merete; Destefano, Anita L; Myers, Richard H; Lash, Timothy L (BioMed Central, 2010-4-12)
    BACKGROUND: Women have a reduced risk of developing Parkinson's disease (PD) compared with age-matched men. Neuro-protective effects of estrogen potentially explain this difference. Tamoxifen, commonly used in breast cancer ...
  • Kapoor, Alok; Labonte, Alan J; Winter, Michael R; Segal, Jodi B; Silliman, Rebecca A; Katz, Jeffrey N; Losina, Elena; Berlowitz, Dan (BioMed Central, 2010-9-17)
    BACKGROUND: Venous thromboembolism is a common, fatal, and costly injury which complicates major surgery in older adults. The American College of Chest Physicians recommends high potency prophylaxis regimens for individuals ...
  • Sebastiani, Paola; Montano, Monty; Puca, Annibale; Solovieff, Nadia; Kojima, Toshio; Wang, Meng C.; Melista, Efthymia; Meltzer, Micah; Fischer, Sylvia E. J.; Andersen, Stacy; Hartley, Stephen H.; Sedgewick, Amanda; Arai, Yasumichi; Bergman, Aviv; Barzilai, Nir; Terry, Dellara F.; Riva, Alberto; Anselmi, Chiara Viviani; Malovini, Alberto; Kitamoto, Aya; Sawabe, Motoji; Arai, Tomio; Gondo, Yasuyuki; Steinberg, Martin H.; Hirose, Nobuyoshi; Atzmon, Gil; Ruvkun, Gary; Baldwin, Clinton T.; Perls, Thomas T. (Public Library of Science, 2009-12-14)
    BACKGROUND. The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein ...
  • Yazdanpanah, Yazdan; Sloan, Caroline E.; Charlois-Ou, Cécile; Le Vu, Stéphane; Semaille, Caroline; Costagliola, Dominique; Pillonel, Josiane; Poullié, Anne-Isabelle; Scemama, Olivier; Deuffic-Burban, Sylvie; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth A.; Paltiel, A. David (Public Library of Science, 2010-10-1)
    BACKGROUND. In France, roughly 40,000 HIV-infected persons are unaware of their HIV infection. Although previous studies have evaluated the cost-effectiveness of routine HIV screening in the United States, differences in ...

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