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Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons.

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dc.contributor.author Sobus, J.R.
dc.contributor.author Waidyanatha, S
dc.contributor.author McClean, M.D.
dc.contributor.author Herrick, R.F.
dc.contributor.author Smith, T.J.
dc.contributor.author Garshick, E
dc.contributor.author Laden, F
dc.contributor.author Hart, J.E.
dc.contributor.author Zheng, Y
dc.contributor.author Rappaport, S.M.
dc.date.accessioned 2009-10-17T14:22:26Z
dc.date.available 2009-10-17T14:22:26Z
dc.date.issued 2009
dc.identifier.citation Sobus, J. R., Waidyanatha, S., McClean, M. D., Herrick, R. F., Smith, T. J., Garshick, E., Laden, F., Hart, J. E., Zheng, Y., & Rappaport, S. M. (2009). Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons. Occupational and Environmental Medicine, 66(2), 99-104. doi:10.1136/oem.2008.041418 en_US
dc.identifier.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633650/?tool=pmcentrez en_US
dc.identifier.uri http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19017700 en_US
dc.identifier.uri http://hdl.handle.net/2144/1207
dc.description.abstract OBJECTIVES: The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs). METHODS: The report included workers exposed to diesel exhausts (low PAH exposure level, n = 39) as well as those exposed to emissions from asphalt (medium PAH exposure level, n = 26) and coke ovens (high PAH exposure level, n = 28). Levels of Nap and Phe were measured in urine from each subject using head space-solid phase microextraction and gas chromatography-mass spectrometry. Published levels of airborne Nap, Phe and other PAHs in the coke-producing and aluminium industries were also investigated. RESULTS: In post-shift urine, the highest estimated geometric mean concentrations of Nap and Phe were observed in coke-oven workers (Nap: 2490 ng/l; Phe: 975 ng/l), followed by asphalt workers (Nap: 71.5 ng/l; Phe: 54.3 ng/l), and by diesel-exposed workers (Nap: 17.7 ng/l; Phe: 3.60 ng/l). After subtracting logged background levels of Nap and Phe from the logged post-shift levels of these PAHs in urine, the resulting values (referred to as ln(adjNap) and ln(adjPhe), respectively) were significantly correlated in each group of workers (0.71 < or = Pearson r < or = 0.89), suggesting a common exposure source in each case. Surprisingly, multiple linear regression analysis of ln(adjNap) on ln(adjPhe) showed no significant effect of the source of exposure (coke ovens, asphalt and diesel exhaust) and further suggested that the ratio of urinary Nap/Phe (in natural scale) decreased with increasing exposure levels. These results were corroborated with published data for airborne Nap and Phe in the coke-producing and aluminium industries. The published air measurements also indicated that Nap and Phe levels were proportional to the levels of all combined PAHs in those industries. CONCLUSION: Levels of Nap and Phe in urine reflect airborne exposures to these compounds and are promising surrogates for occupational exposures to PAH mixtures. en_US
dc.publisher BMJ Publishing Group en_US
dc.source Published in final edited form as: Occup Environ Med. 2009 February; 66(2): 99–104. Published online 2008 November 18. doi: 10.1136/oem.2008.041418.
dc.title Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons. en_US
dc.type Article en_US


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