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dc.contributor.authorWarren, Wesley C.en_US
dc.contributor.authorJasinska, Anna J.en_US
dc.contributor.authorGarcía-Pérez, Raquelen_US
dc.contributor.authorSvardal, Hannesen_US
dc.contributor.authorTomlinson, Chaden_US
dc.contributor.authorRocchi, Marianoen_US
dc.contributor.authorArchidiacono, Nicolettaen_US
dc.contributor.authorCapozzi, Oronzoen_US
dc.contributor.authorMinx, Patricken_US
dc.contributor.authorMontague, Michael J.en_US
dc.contributor.authorKyung, Kimen_US
dc.contributor.authorHillier, LaDeana W.en_US
dc.contributor.authorKremitzki, Milinnen_US
dc.contributor.authorGraves, Tinaen_US
dc.contributor.authorChiang, Colbyen_US
dc.contributor.authorHughes, Jenniferen_US
dc.contributor.authorTran, Namen_US
dc.contributor.authorHuang, Yuen_US
dc.contributor.authorRamensky, Vasilyen_US
dc.contributor.authorChoi, Oi-waen_US
dc.contributor.authorJung, Yoon J.en_US
dc.contributor.authorSchmitt, Christopher A.en_US
dc.contributor.authorJuretic, Nikoletaen_US
dc.contributor.authorWasserscheid, Jessicaen_US
dc.contributor.authorTurner, Trudy R.en_US
dc.contributor.authorWiseman, Roger W.en_US
dc.contributor.authorTuscher, Jennifer J.en_US
dc.contributor.authorKarl, Julie A.en_US
dc.contributor.authorSchmitz, Jörn E.en_US
dc.contributor.authorZahn, Rolanden_US
dc.contributor.authorO'Connor, David H.en_US
dc.contributor.authorRedmond, Eugeneen_US
dc.contributor.authorNisbett, Alexen_US
dc.contributor.authorJacquelin, Béatriceen_US
dc.contributor.authorMüller-Trutwin, Michaela C.en_US
dc.contributor.authorBrenchley, Jason M.en_US
dc.contributor.authorDione, Michelen_US
dc.contributor.authorAntonio, Martinen_US
dc.contributor.authorSchroth, Gary P.en_US
dc.contributor.authorKaplan, Jay R.en_US
dc.contributor.authorJorgensen, Matthew J.en_US
dc.contributor.authorThomas, Gregg W.C.en_US
dc.contributor.authorHahn, Matthew W.en_US
dc.contributor.authorRaney, Brian J.en_US
dc.contributor.authorAken, Bronwenen_US
dc.contributor.authorNag, Rishien_US
dc.contributor.authorSchmitz, Juergenen_US
dc.contributor.authorChurakov, Gennadyen_US
dc.contributor.authorNoll, Angelaen_US
dc.contributor.authorStanyon, Roscoeen_US
dc.contributor.authorWebb, Daviden_US
dc.contributor.authorThibaud-Nissen, Francoiseen_US
dc.contributor.authorNordborg, Magnusen_US
dc.contributor.authorMarques-Bonet, Tomasen_US
dc.contributor.authorDewar, Kenen_US
dc.contributor.authorWeinstock, George M.en_US
dc.contributor.authorWilson, Richard K.en_US
dc.contributor.authorFreimer, Nelson B.en_US
dc.date.accessioned2017-04-20T02:36:42Z
dc.date.available2017-04-20T02:36:42Z
dc.date.issued2015-12
dc.identifier.citationWesley C Warren, Anna J Jasinska, Raquel García-Pérez, Hannes Svardal, Chad Tomlinson, Mariano Rocchi, Nicoletta Archidiacono, Oronzo Capozzi, Patrick Minx, Michael J Montague, Kim Kyung, LaDeana W Hillier, Milinn Kremitzki, Tina Graves, Colby Chiang, Jennifer Hughes, Nam Tran, Yu Huang, Vasily Ramensky, Oi-wa Choi, Yoon J Jung, Christopher A Schmitt, Nikoleta Juretic, Jessica Wasserscheid, Trudy R Turner, Roger W Wiseman, Jennifer J Tuscher, Julie A Karl, Jörn E Schmitz, Roland Zahn, David H O'Connor, Eugene Redmond, Alex Nisbett, Béatrice Jacquelin, Michaela C Müller-Trutwin, Jason M Brenchley, Michel Dione, Martin Antonio, Gary P Schroth, Jay R Kaplan, Matthew J Jorgensen, Gregg WC Thomas, Matthew W Hahn, Brian J Raney, Bronwen Aken, Rishi Nag, Juergen Schmitz, Gennady Churakov, Angela Noll, Roscoe Stanyon, David Webb, Francoise Thibaud-Nissen, Magnus Nordborg, Tomas Marques-Bonet, Ken Dewar, George M Weinstock, Richard K Wilson, Nelson B Freimer. 2015. "The genome of the vervet ( Chlorocebus aethiops sabaeus )." Genome Research, Volume 25, Issue 12, pp. 1921 - 1933.
dc.identifier.issn1088-9051
dc.identifier.issn1549-5469
dc.identifier.urihttp://hdl.handle.net/2144/21324
dc.description.abstractWe describe a genome reference of the African green monkey or vervet (Chlorocebus aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for genetic investigations of simian immunodeficiency virus (SIV), for which it is the most abundant natural host species, and of a wide range of health-related phenotypes assessed in Caribbean vervets (C. a. sabaeus), whose numbers have expanded dramatically since Europeans introduced small numbers of their ancestors from West Africa during the colonial era. We use the reference to characterize the genomic relationship between vervets and other primates, the intra-generic phylogeny of vervet subspecies, and genome-wide structural variations of a pedigreed C. a. sabaeus population. Through comparative analyseswith human and rhesus macaque, we characterize at high resolution the unique chromosomal fission events that differentiate the vervets and their close relatives from most other catarrhine primates, in whom karyotype is highly conserved. We also provide a summary of transposable elements and contrast these with the rhesus macaque and human. Analysis of sequenced genomes representing each of the main vervet subspecies supports previously hypothesized relationships between these populations, which range across most of sub-Saharan Africa, while uncovering high levels of genetic diversity within each. Sequence-based analyses of major histocompatibility complex (MHC) polymorphisms reveal extremely low diversity in Caribbean C. a. sabaeus vervets, compared to vervets from putatively ancestral West African regions. In the C. a. sabaeus research population, we discover the first structural variations that are, in some cases, predicted to have a deleterious effect; future studies will determine the phenotypic impact of these variations.
dc.description.sponsorship5U54HG00307907 - NIH-NHGRI; RR019963/OD010965 - NIH; NIH; R01RR016300; R01OD010980; Ministero della Universita’ e della Ricercaen_US
dc.format.extent1921 - 1933en_US
dc.relation.ispartofGenome Researchen_US
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectChlorocebus aethiopsen_US
dc.subjectVerveten_US
dc.subjectBioinformaticsen_US
dc.titleThe genome of the vervet ( Chlorocebus aethiops sabaeus )en_US
dc.typeArticle
dc.identifier.doi10.1101/gr.192922.115
pubs.elements-sourcecrossrefen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Anthropologyen_US
pubs.publication-statusPublisheden_US
dc.date.online2015-09-16
dc.date.online2015-09-16
dc.identifier.orcid0000-0003-2143-9226 (Schmitt, Christopher A)


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