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Browsing Framingham Heart Study by Title

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Browsing Framingham Heart Study by Title

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  • Kathiresan, Sekar; Manning, Alisa K; Demissie, Serkalem; D'Agostino, Ralph B; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Burtt, Nöel P; Melander, Olle; Orho-Melander, Marju; Arnett, Donna K; Peloso, Gina M; Ordovas, Jose M; Cupples, L Adrienne (BioMed Central, 2007-9-19)
    BACKGROUND: Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-wide association is a promising approach ...
  • Kottgen, Anna; Kao, Wen Hong L; Hwang, Shih-Jen; Boerwinkle, Eric; Yang, Qiong; Levy, Daniel; Benjamin, Emelia J; Larson, Martin G; Astor, Brad C; Coresh, Josef; Fox, Caroline S (BioMed Central, 2008-6-3)
    BACKGROUND: The Framingham Heart Study (FHS) recently obtained initial results from the first genome-wide association scan for renal traits. The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants ...
  • O'Donnell, Christopher J; Cupples, L Adrienne; D'Agostino, Ralph B; Fox, Caroline S; Hoffmann, Udo; Hwang, Shih-Jen; Ingellson, Erik; Liu, Chunyu; Murabito, Joanne M; Polak, Joseph F; Wolf, Philip A; Demissie, Serkalem (BioMed Central, 2007-9-19)
    INTRODUCTION: Subclinical atherosclerosis (SCA) measures in multiple arterial beds are heritable phenotypes that are associated with increased incidence of cardiovascular disease. We conducted a genome-wide association ...
  • Murabito, Joanne M; Rosenberg, Carol L; Finger, Daniel; Kreger, Bernard E; Levy, Daniel; Splansky, Greta Lee; Antman, Karen; Hwang, Shih-Jen (BioMed Central, 2007-9-19)
    BACKGROUND: Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified. METHODS: We conducted a ...
  • Newton-Cheh, Christopher; Guo, Chao-Yu; Wang, Thomas J; O'Donnell, Christopher J; Levy, Daniel; Larson, Martin G (BioMed Central, 2007-9-19)
    BACKGROUND: Heritable electrocardiographic (ECG) and heart rate variability (HRV) measures, reflecting pacemaking, conduction, repolarization and autonomic function in the heart have been associated with risks for cardiac ...
  • Wilk, Jemma B.; Chen, Ting-hsu; Gottlieb, Daniel J.; Walter, Robert E.; Nagle, Michael W.; Brandler, Brian J.; Myers, Richard H.; Borecki, Ingrid B.; Silverman, Edwin K.; Weiss, Scott T.; O'Connor, George T. (Public Library of Science, 2009-3-20)
    The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ...
  • Fox, Caroline S; Heard-Costa, Nancy; Cupples, L Adrienne; Dupuis, Josée; Vasan, Ramachandran S; Atwood, Larry D (BioMed Central, 2007-9-19)
    BACKGROUND: Obesity is related to multiple cardiovascular disease (CVD) risk factors as well as CVD and has a strong familial component. We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures ...
  • Kiel, Douglas P; Demissie, Serkalem; Dupuis, Josée; Lunetta, Kathryn L; Murabito, Joanne M; Karasik, David (BioMed Central, 2007-9-19)
    BACKGROUND: Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits ...
  • Meigs, James B; Manning, Alisa K; Fox, Caroline S; Florez, Jose C; Liu, Chunyu; Cupples, L Adrienne; Dupuis, Josée (BioMed Central, 2007-9-19)
    BACKGROUND: Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants. METHODS: We used the ...
  • Benjamin, Emelia J; Dupuis, Josée; Larson, Martin G; Lunetta, Kathryn L; Booth, Sarah L; Govindaraju, Diddahally R; Kathiresan, Sekar; Keaney, John F; Keyes, Michelle J; Lin, Jing-Ping; Meigs, James B; Robins, Sander J; Rong, Jian; Schnabel, Renate; Vita, Joseph A; Wang, Thomas J; Wilson, Peter WF; Wolf, Philip A; Vasan, Ramachandran S (BioMed Central, 2007-9-19)
    BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provide ...
  • Stolerman, Elliot S.; Manning, Alisa K.; McAteer, Jarred B.; Dupuis, Josée; Fox, Caroline S.; Cupples, L. Adrienne; Meigs, James B.; Florez, Jose C. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: A recent meta-analysis demonstrated a nominal association of the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K→Q missense single nucleotide polymorphism (SNP) at position 121 with type 2 diabetes. ...
  • Guo, Chao-Yu (BioMed Central, 2007-12-18)
    The transmission/disequilibrium test was introduced to test for linkage and association between a marker and a putative disease locus using case-parent triads. Several extensions have been proposed to accommodate incomplete ...
  • Guo, Chao-Yu; Cui, Jing; Cupples, L Adrienne (BioMed Central, 2005-12-30)
    The transmission/disequilibrium test was introduced to test for linkage disequilibrium between a marker and a putative disease locus using case-parent trios. However, parental genotypes may be incomplete in such a study. ...
  • Manning, Alisa K; Ngwa, Julius Suh; Hendricks, Audrey E; Liu, Ching-Ti; Johnson, Andrew D; Dupuis, Josée; Cupples, L Adrienne (BioMed Central, 2009-12-15)
    We sought to find significant gene × gene interaction in a genome-wide association analysis of rheumatoid arthritis (RA) by performing pair-wise tests of interaction among collections of single-nucleotide polymorphisms ...
  • Hsu, Yi-Hsiang; Zillikens, M. Carola; Wilson, Scott G.; Farber, Charles R.; Demissie, Serkalem; Soranzo, Nicole; Bianchi, Estelle N.; Grundberg, Elin; Liang, Liming; Richards, J. Brent; Estrada, Karol; Zhou, Yanhua; van Nas, Atila; Moffatt, Miriam F.; Zhai, Guangju; Hofman, Albert; van Meurs, Joyce B.; Pols, Huibert A. P.; Price, Roger I.; Nilsson, Olle; Pastinen, Tomi; Cupples, L. Adrienne; Lusis, Aldons J.; Schadt, Eric E.; Ferrari, Serge; Uitterlinden, André G.; Rivadeneira, Fernando; Spector, Timothy D.; Karasik, David; Kiel, Douglas P. (Public Library of Science, 2010-6-10)
    Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect ...
  • Deo, Rahul C.; Hunter, Luke; Lewis, Gregory D.; Pare, Guillaume; Vasan, Ramachandran S.; Chasman, Daniel; Wang, Thomas J.; Gerszten, Robert E.; Roth, Frederick P. (Public Library of Science, 2010-2-26)
    Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the ...
  • Fox, Caroline S.; Pencina, Michael J.; Wilson, Peter W.F.; Paynter, Nina P.; Vasan, Ramachandran S.; D'Agostino, Ralph B. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS: Participants were drawn from the original and offspring cohorts ...
  • Shaham, Oded; Wei, Ru; Wang, Thomas J; Ricciardi, Catherine; Lewis, Gregory D; Vasan, Ramachandran S; Carr, Steven A; Thadhani, Ravi; Gerszten, Robert E; Mootha, Vamsi K (Nature Publishing GroupMolecular Systems Biology, 2008-08-05)
    Glucose ingestion after an overnight fast triggers an insulin-dependent, homeostatic program that is altered in diabetes. The full spectrum of biochemical changes associated with this transition is currently unknown. We ...
  • Heard-Costa, Nancy L.; Zillikens, M. Carola; Monda, Keri L.; Johansson, Åsa; Harris, Tamara B.; Fu, Mao; Haritunians, Talin; Feitosa, Mary F.; Aspelund, Thor; Eiriksdottir, Gudny; Garcia, Melissa; Launer, Lenore J.; Smith, Albert V.; Mitchell, Braxton D.; McArdle, Patrick F.; Shuldiner, Alan R.; Bielinski, Suzette J.; Boerwinkle, Eric; Brancati, Fred; Demerath, Ellen W.; Pankow, James S.; Arnold, Alice M.; Chen, Yii-Der Ida; Glazer, Nicole L.; McKnight, Barbara; Psaty, Bruce M.; Rotter, Jerome I.; Amin, Najaf; Campbell, Harry; Gyllensten, Ulf; Pattaro, Cristian; Pramstaller, Peter P.; Rudan, Igor; Struchalin, Maksim; Vitart, Veronique; Gao, Xiaoyi; Kraja, Aldi; Province, Michael A.; Zhang, Qunyuan; Atwood, Larry D.; Dupuis, Josée; Hirschhorn, Joel N.; Jaquish, Cashell E.; O'Donnell, Christopher J.; Vasan, Ramachandran S.; White, Charles C.; Aulchenko, Yurii S.; Estrada, Karol; Hofman, Albert; Rivadeneira, Fernando; Uitterlinden, André G.; Witteman, Jacqueline C. M.; Oostra, Ben A.; Kaplan, Robert C.; Gudnason, Vilmundur; O'Connell, Jeffrey R.; Borecki, Ingrid B.; van Duijn, Cornelia M.; Cupples, L. Adrienne; Fox, Caroline S.; North, Kari E. (Public Library of Science, 2009-6-26)
    Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist ...
  • Kimura, Masayuki; Cherkas, Lynn F; Kato, Bernet S; Demissie, Serkalem; Hjelmborg, Jacob B; Brimacombe, Michael; Cupples, Adrienne; Hunkin, Janice L; Gardner, Jefferey P; Lu, Xiaobin; Cao, Xiaojian; Sastrasinh, Malinee; Province, Michael A; Hunt, Steven C; Christensen, Kaare; Levy, Daniel; Spector, Tim D; Aviv, Abraham (Public Library of Science, 2008-2-15)
    Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We ...

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