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Browsing Framingham Heart Study Papers by Issue Date

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Browsing Framingham Heart Study Papers by Issue Date

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  • Atwood, Larry D; Heard-Costa, Nancy L; Cupples, L Adrienne; Levy, Daniel (BioMed Central, 2003-12-31)
    BACKGROUND. The repeated measures in the Framingham Heart Study in the Genetic Analysis Workshop 13 data set allow us to test for consistency of linkage results within a study across time. We compared regression-based ...
  • Cupples, L Adrienne; Yang, Qiong; Demissie, Serkalem; Copenhafer, Donna; Levy, Daniel (BioMed Central, 2003-12-31)
  • Guo, Chao-Yu; Cui, Jing; Cupples, L Adrienne (BioMed Central, 2005-12-30)
    The transmission/disequilibrium test was introduced to test for linkage disequilibrium between a marker and a putative disease locus using case-parent trios. However, parental genotypes may be incomplete in such a study. ...
  • Atwood, Larry D; Heard-Costa, Nancy L; Fox, Caroline S; Jaquish, Cashell E; Cupples, L Adrienne (BioMed Central, 2006-1-26)
    BACKGROUND: Previously, we reported significant linkage of body mass index (BMI) to chromosomes 6 and 11 across six examinations, covering 28 years, of the Framingham Heart Study. These results were on all individuals ...
  • Levy, Daniel; DePalma, Steven R; Benjamin, Emelia J; O'Donnell, Christopher J; Parise, Helen; Hirschhorn, Joel N; Vasan, Ramachandran S; Izumo, Seigo; Larson, Martin G (BioMed Central, 2006-5-22)
    BACKGROUND: High-throughput genotyping generates vast amounts of data for analysis; results can be difficult to summarize succinctly. A single project may involve genotyping many genes with multiple variants per gene and ...
  • Guo, Chao-Yu (BioMed Central, 2007-12-18)
    The transmission/disequilibrium test was introduced to test for linkage and association between a marker and a putative disease locus using case-parent triads. Several extensions have been proposed to accommodate incomplete ...
  • Newton-Cheh, Christopher; Guo, Chao-Yu; Wang, Thomas J; O'Donnell, Christopher J; Levy, Daniel; Larson, Martin G (BioMed Central, 2007-9-19)
    BACKGROUND: Heritable electrocardiographic (ECG) and heart rate variability (HRV) measures, reflecting pacemaking, conduction, repolarization and autonomic function in the heart have been associated with risks for cardiac ...
  • Murabito, Joanne M; Rosenberg, Carol L; Finger, Daniel; Kreger, Bernard E; Levy, Daniel; Splansky, Greta Lee; Antman, Karen; Hwang, Shih-Jen (BioMed Central, 2007-9-19)
    BACKGROUND: Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified. METHODS: We conducted a ...
  • Larson, Martin G; Atwood, Larry D; Benjamin, Emelia J; Cupples, L Adrienne; D'Agostino, Ralph B; Fox, Caroline S; Govindaraju, Diddahally R; Guo, Chao-Yu; Heard-Costa, Nancy L; Hwang, Shih-Jen; Murabito, Joanne M; Newton-Cheh, Christopher; O'Donnell, Christopher J; Seshadri, Sudha; Vasan, Ramachandran S; Wang, Thomas J; Wolf, Philip A; Levy, Daniel (BioMed Central, 2007-9-19)
    BACKGROUND: Cardiovascular disease (CVD) and its most common manifestations – including coronary heart disease (CHD), stroke, heart failure (HF), and atrial fibrillation (AF) – are major causes of morbidity and mortality. ...
  • Cupples, L Adrienne; Arruda, Heather T; Benjamin, Emelia J; D'Agostino, Ralph B; Demissie, Serkalem; DeStefano, Anita L; Dupuis, Josée; Falls, Kathleen M; Fox, Caroline S; Gottlieb, Daniel J; Govindaraju, Diddahally R; Guo, Chao-Yu; Heard-Costa, Nancy L; Hwang, Shih-Jen; Kathiresan, Sekar; Kiel, Douglas P; Laramie, Jason M; Larson, Martin G; Levy, Daniel; Liu, Chun-Yu; Lunetta, Kathryn L; Mailman, Matthew D; Manning, Alisa K; Meigs, James B; Murabito, Joanne M; Newton-Cheh, Christopher; O'Connor, George T; O'Donnell, Christopher J; Pandey, Mona; Seshadri, Sudha; Vasan, Ramachandran S; Wang, Zhen Y; Wilk, Jemma B; Wolf, Philip A; Yang, Qiong; Atwood, Larry D (BioMed Central, 2007-9-19)
    BACKGROUND: The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected ...
  • Vasan, Ramachandran S; Larson, Martin G; Aragam, Jayashri; Wang, Thomas J; Mitchell, Gary F; Kathiresan, Sekar; Newton-Cheh, Christopher; Vita, Joseph A; Keyes, Michelle J; O'Donnell, Christopher J; Levy, Daniel; Benjamin, Emelia J (BioMed Central, 2007-9-19)
    BACKGROUND: Echocardiographic left ventricular (LV) measurements, exercise responses to standardized treadmill test (ETT) and brachial artery (BA) vascular function are heritable traits that are associated with cardiovascular ...
  • Benjamin, Emelia J; Dupuis, Josée; Larson, Martin G; Lunetta, Kathryn L; Booth, Sarah L; Govindaraju, Diddahally R; Kathiresan, Sekar; Keaney, John F; Keyes, Michelle J; Lin, Jing-Ping; Meigs, James B; Robins, Sander J; Rong, Jian; Schnabel, Renate; Vita, Joseph A; Wang, Thomas J; Wilson, Peter WF; Wolf, Philip A; Vasan, Ramachandran S (BioMed Central, 2007-9-19)
    BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provide ...
  • Levy, Daniel; Larson, Martin G; Benjamin, Emelia J; Newton-Cheh, Christopher; Wang, Thomas J; Hwang, Shih-Jen; Vasan, Ramachandran S; Mitchell, Gary F (BioMed Central, 2007-9-19)
    BACKGROUND: About one quarter of adults are hypertensive and high blood pressure carries increased risk for heart disease, stroke, kidney disease and death. Increased arterial stiffness is a key factor in the pathogenesis ...
  • Gottlieb, Daniel J; O'Connor, George T; Wilk, Jemma B (BioMed Central, 2007-9-19)
    BACKGROUND: Numerous studies suggest genetic influences on sleepiness and circadian rhythms. The Sleep Heart Health Study collected questionnaire data on sleep habits and sleepiness from 2848 Framingham Heart Study Offspring ...
  • Wilk, Jemma B; Walter, Robert E; Laramie, Jason M; Gottlieb, Daniel J; O'Connor, George T (BioMed Central, 2007-9-19)
    BACKGROUND: Pulmonary function measures obtained by spirometry are used to diagnose chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted genome-wide association (GWA) analyses (Affymetrix ...
  • Fox, Caroline S; Heard-Costa, Nancy; Cupples, L Adrienne; Dupuis, Josée; Vasan, Ramachandran S; Atwood, Larry D (BioMed Central, 2007-9-19)
    BACKGROUND: Obesity is related to multiple cardiovascular disease (CVD) risk factors as well as CVD and has a strong familial component. We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures ...
  • Kathiresan, Sekar; Manning, Alisa K; Demissie, Serkalem; D'Agostino, Ralph B; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Burtt, Nöel P; Melander, Olle; Orho-Melander, Marju; Arnett, Donna K; Peloso, Gina M; Ordovas, Jose M; Cupples, L Adrienne (BioMed Central, 2007-9-19)
    BACKGROUND: Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-wide association is a promising approach ...
  • Meigs, James B; Manning, Alisa K; Fox, Caroline S; Florez, Jose C; Liu, Chunyu; Cupples, L Adrienne; Dupuis, Josée (BioMed Central, 2007-9-19)
    BACKGROUND: Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants. METHODS: We used the ...
  • Seshadri, Sudha; DeStefano, Anita L; Au, Rhoda; Massaro, Joseph M; Beiser, Alexa S; Kelly-Hayes, Margaret; Kase, Carlos S; D'Agostino, Ralph B; DeCarli, Charles; Atwood, Larry D; Wolf, Philip A (BioMed Central, 2007-9-19)
    BACKGROUND: Brain magnetic resonance imaging (MRI) and cognitive tests can identify heritable endophenotypes associated with an increased risk of developing stroke, dementia and Alzheimer's disease (AD). We conducted a ...
  • Yang, Qiong; Kathiresan, Sekar; Lin, Jing-Ping; Tofler, Geoffrey H; O'Donnell, Christopher J (BioMed Central, 2007-9-19)
    BACKGROUND: Increased circulating levels of hemostatic factors as well as anemia have been associated with increased risk of cardiovascular disease (CVD). Known associations between hemostatic factors and sequence variants ...

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