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Evidence for a Gene Influencing Heart Rate on Chromosome 5P13-14 in a Meta-Analysis of Genome-Wide Scans from the NHLBI Family Blood Pressure Program

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dc.contributor.author Laramie, Jason M en_US
dc.contributor.author Wilk, Jemma B en_US
dc.contributor.author Hunt, Steven C en_US
dc.contributor.author Ellison, R Curtis en_US
dc.contributor.author Chakravarti, Aravinda en_US
dc.contributor.author Boerwinkle, Eric en_US
dc.contributor.author Myers, Richard H en_US
dc.date.accessioned 2011-12-29T21:02:16Z
dc.date.available 2011-12-29T21:02:16Z
dc.date.copyright 2006 en_US
dc.date.issued 2006-3-1 en_US
dc.identifier.citation Laramie, Jason M, Jemma B Wilk, Steven C Hunt, R Curtis Ellison, Aravinda Chakravarti, Eric Boerwinkle, Richard H Myers. "Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program." BMC Medical Genetics 7:17. (2006) en_US
dc.identifier.issn 1471-2350 en_US
dc.identifier.uri http://hdl.handle.net/2144/2499
dc.description.abstract BACKGROUND: Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic linkage scans to identify quantitative trait loci. METHODS: We performed a genome-wide linkage scan to identify quantitative trait loci influencing resting heart rate among 3,282 Caucasians and 3,989 African-Americans in three independent networks comprising the Family Blood Pressure Program (FBPP) using 368 microsatellite markers. Mean heart rate measurements were used in a regression model including covariates for age, body mass index, pack-years, currently drinking alcohol (yes/no), hypertension status and medication usage to create a standardized residual for each gender/ethnic group within each study network. This residual was used in a nonparametric variance component model to generate a LOD score and a corresponding P value for each ethnic group within each study network. P values from each ethnic group and study network were merged using an adjusted Fisher's combining P values method and the resulting P values were converted to LOD scores. The entire analysis was redone after individuals currently taking beta-blocker medication were removed. RESULTS: We identified significant evidence of linkage (LOD = 4.62) to chromosome 10 near 142.78 cM in the Caucasian group of HyperGEN. Between race and network groups we identified a LOD score of 1.86 on chromosome 5 (between 39.99 and 45.34 cM) in African-Americans in the GENOA network and the same region produced a LOD score of 1.12 among Caucasians within a different network (HyperGEN). Combining all network and race groups we identified a LOD score of 1.92 (P = 0.0013) on chromosome 5p13-14. We assessed heterogeneity for this locus between networks and ethnic groups and found significant evidence for low heterogeneity (P ≤ 0.05). CONCLUSION: We found replication (LOD > 1) between ethnic groups and between study networks with low heterogeneity on chromosome 5p13-14 suggesting that a gene in this region influences resting heart rate. en_US
dc.description.sponsorship National Heart, Lung, and Blood Institute (GenNEt HL45508, HL47910, GENOA R01 HL51021, U10 HL54481, HL54464, HyperGEN, HL54473, HL54496, HL54472, HL54515, HL54495, HL54497, HL54471, HL54509) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2006 Laramie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Evidence for a Gene Influencing Heart Rate on Chromosome 5P13-14 in a Meta-Analysis of Genome-Wide Scans from the NHLBI Family Blood Pressure Program en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2350-7-17 en_US
dc.identifier.pubmedid 16509988 en_US
dc.identifier.pmcid 1413518 en_US


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Copyright 2006 Laramie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright 2006 Laramie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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