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Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions

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dc.contributor.author Koido, Shigeo en_US
dc.contributor.author Homma, Sadamu en_US
dc.contributor.author Hara, Eiichi en_US
dc.contributor.author Namiki, Yoshihisa en_US
dc.contributor.author Takahara, Akitaka en_US
dc.contributor.author Komita, Hideo en_US
dc.contributor.author Nagasaki, Eijiro en_US
dc.contributor.author Ito, Masaki en_US
dc.contributor.author Ohkusa, Toshifumi en_US
dc.contributor.author Gong, Jianlin en_US
dc.contributor.author Tajiri, Hisao en_US
dc.date.accessioned 2011-12-29T21:02:25Z
dc.date.available 2011-12-29T21:02:25Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-10-26 en_US
dc.identifier.citation Koido, Shigeo, Sadamu Homma, Eiichi Hara, Yoshihisa Namiki, Akitaka Takahara, Hideo Komita, Eijiro Nagasaki, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri. "Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions" Clinical and Developmental Immunology 2010:516768. (2010) en_US
dc.identifier.issn 1740-2530 en_US
dc.identifier.uri http://hdl.handle.net/2144/2532
dc.description.abstract The goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce antitumor immune responses against tumors have been tested in clinical trials worldwide. Although DCs-based vaccine such as fusions of whole tumor cells and DCs has been proven to be clinically safe and is efficient to enhance antitumor immune responses for inducing effective immune response and for breaking T-cell tolerance to tumor-associated antigens (TAAs), only a limited success has occurred in clinical trials. This paper reviews tumor immune escape and current strategies employed in the field of tumor/DC fusions vaccine aimed at enhancing activation of TAAs-specific cytotoxic T cells in tumor microenvironment. en_US
dc.description.sponsorship Foundation for the Promotion of Cancer Research; Mitsui Life Social Welfare Foundation; Grants-in-Aid for Scientific Research from the Ministry of Education, Cultures, Sports, Science, and Technology of Japan; Grant-in-Aid of the Japan Medical Association; Takeda Science Foundation; Pancreas Research Foundation of Japan en_US
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.rights Copyright 2010 Koido et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.title Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions en_US
dc.type article en_US
dc.identifier.doi 10.1155/2010/516768 en_US
dc.identifier.pubmedid 21048993 en_US
dc.identifier.pmcid 2964897 en_US


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