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Burden and Rates of Treatment and Control of Cardiovascular Disease Risk Factors in Obesity

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dc.contributor.author Molenaar, Esther A. en_US
dc.contributor.author Hwang, Shih-Jen en_US
dc.contributor.author Vasan, Ramachandran S. en_US
dc.contributor.author Grobbee, Diederick E. en_US
dc.contributor.author Meigs, James B. en_US
dc.contributor.author D'Agostino, Ralph B. en_US
dc.contributor.author Levy, Daniel en_US
dc.contributor.author Fox, Caroline S. en_US
dc.date.accessioned 2011-12-29T21:03:22Z
dc.date.available 2011-12-29T21:03:22Z
dc.date.issued 2011-12-29
dc.identifier.citation Molenaar, Esther A., Shih-Jen Hwang, Ramachandran S. Vasan, Diederick E. Grobbee, James B. Meigs, Ralph B. D'Agostino, Daniel Levy, Caroline S. Fox. "Burden and Rates of Treatment and Control of Cardiovascular Disease Risk Factors in Obesity" Diabetes Care 31(7): 1367-1372. (2008) en_US
dc.identifier.issn 1935-5548 en_US
dc.identifier.uri http://hdl.handle.net/2144/2546
dc.description.abstract OBJECTIVE: Obesity is associated with an increased risk for cardiovascular disease (CVD). We sought to determine rates of treatment and control of CVD risk factors among normal weight, overweight, and obese individuals in a community-based cohort. RESEARCH DESIGN AND METHODS: Participants free of CVD (n = 6,801; mean age 49 years; 54% women) from the Framingham Offspring and Third Generation cohorts who attended the seventh Offspring examination (1998–2001) or first Third Generation (2002–2005) examination were studied. RESULTS: Obese participants with hypertension were more likely to receive antihypertensive treatment (62.3%) than normal weight (58.7%) or overweight (59.0%) individuals (P = 0.002), but no differences in hypertension control across BMI subgroups among participants with hypertension were observed (36.7% [normal weight], 37.3% [overweight], and 39.4% [obese]; P = 0.48). Rates of lipid-lowering treatment were higher among obese participants with elevated LDL cholesterol (39.5%) compared with normal weight (34.2%) or overweight (36.4%) participants (P = 0.02), but control rates among those with elevated LDL cholesterol did not differ across BMI categories (26.7% [normal weight], 26.0% [overweight], and 29.2% [obese]; P = 0.11). There were no differences in diabetes treatment among participants with diabetes across BMI groups (69.2% [normal weight], 50.0% [overweight], 55.0% [obese]; P = 0.54), but obese participants with diabetes were less likely to have fasting blood glucose <126 mg/dl (15.7%) compared with normal weight (30.4%) or overweight (20.7%) participants (P = 0.02). CONCLUSIONS: These findings emphasize the suboptimal rates of treatment and control of CVD risk factors among overweight and obese individuals. en_US
dc.description.sponsorship National Insitutes of Health's National Heart, Lung, and Blood Association's Framingham Heart Study (N01-HC-25195); Netherlands Organization for Scientific Research; Netherlands Heart Foundation; National Heart, Lung, and Blood Institute (2K24 HL 04334); National Institute of Diabetes and Digestive and Kidney Diseases (K24 DK080140) en_US
dc.language.iso en en_US
dc.publisher American Diabetes Association en_US
dc.rights Copyright 2008, American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. en_US
dc.title Burden and Rates of Treatment and Control of Cardiovascular Disease Risk Factors in Obesity en_US
dc.type article en_US
dc.identifier.doi 10.2337/dc07-2413 en_US
dc.identifier.pubmedid 18375414 en_US
dc.identifier.pmcid 2453683 en_US


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