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Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Congenital Anomalies: A Retrospective Cohort Study

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dc.contributor.author Aschengrau, Ann en_US
dc.contributor.author Weinberg, Janice M en_US
dc.contributor.author Janulewicz, Patricia A en_US
dc.contributor.author Gallagher, Lisa G en_US
dc.contributor.author Winter, Michael R en_US
dc.contributor.author Vieira, Veronica M en_US
dc.contributor.author Webster, Thomas F en_US
dc.contributor.author Ozonoff, David M en_US
dc.date.accessioned 2011-12-29T22:21:57Z
dc.date.available 2011-12-29T22:21:57Z
dc.date.copyright 2009 en_US
dc.date.issued 2009-9-24 en_US
dc.identifier.citation Aschengrau, Ann, Janice M Weinberg, Patricia A Janulewicz, Lisa G Gallagher, Michael R Winter, Veronica M Vieira, Thomas F Webster, David M Ozonoff. "Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of congenital anomalies: a retrospective cohort study" 8:44. (2009) en_US
dc.identifier.issn 1476-069X en_US
dc.identifier.uri http://hdl.handle.net/2144/2582
dc.description.abstract BACKGROUND: Prior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (PCE) have shown increases in the risk of certain congenital anomalies among exposed offspring. OBJECTIVES: This retrospective cohort study examined whether PCE contamination of public drinking water supplies in Massachusetts influenced the occurrence of congenital anomalies among children whose mothers were exposed around the time of conception. METHODS: The study included 1,658 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 2,999 children of unexposed mothers. Mothers completed a self-administered questionnaire to gather information on all of their prior births, including the presence of anomalies, residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. RESULTS: Children whose mothers had high exposure levels around the time of conception had an increased risk of congenital anomalies. The adjusted odds ratio of all anomalies combined among children with prenatal exposure in the uppermost quartile was 1.5 (95% CI: 0.9, 2.5). No meaningful increases in the risk were seen for lower exposure levels. Increases were also observed in the risk of neural tube defects (OR: 3.5, 95% CI: 0.8, 14.0) and oral clefts (OR 3.2, 95% CI: 0.7, 15.0) among offspring with any prenatal exposure. CONCLUSION: The results of this study suggest that the risk of certain congenital anomalies is increased among the offspring of women who were exposed to PCE-contaminated drinking water around the time of conception. Because these results are limited by the small number of children with congenital anomalies that were based on maternal reports, a follow-up investigation should be conducted with a larger number of affected children who are identified by independent records. en_US
dc.description.sponsorship National Institute of Environmental Health (5 P42 ES007381); National Institutes of Health en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2009 Aschengrau et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Congenital Anomalies: A Retrospective Cohort Study en_US
dc.type article en_US
dc.identifier.doi 10.1186/1476-069X-8-44 en_US
dc.identifier.pubmedid 19778411 en_US
dc.identifier.pmcid 2761868 en_US


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Copyright 2009 Aschengrau et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright 2009 Aschengrau et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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