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Cross-Sectional Associations Bet ween Abdominal and Thoracic Adipose Tissue Compartments and Adiponectin and Resistin in the Framingham Heart Study

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dc.contributor.author Jain, Shilpa H. en_US
dc.contributor.author Massaro, Joseph M. en_US
dc.contributor.author Hoffmann, Udo en_US
dc.contributor.author Rosito, Guido A. en_US
dc.contributor.author Vasan, Ramachandran S. en_US
dc.contributor.author Raji, Annaswamy en_US
dc.contributor.author O'Donnell, Christopher J. en_US
dc.contributor.author Meigs, James B. en_US
dc.contributor.author Fox, Caroline S. en_US
dc.date.accessioned 2011-12-29T23:03:40Z
dc.date.available 2011-12-29T23:03:40Z
dc.date.issued 2009-2-17 en_US
dc.identifier.citation Jain, Shilpa H., Joseph M. Massaro, Udo Hoffmann, Guido A. Rosito, Ramachandran S. Vasan, Annaswamy Raji, Christopher J. O'Donnell, James B. Meigs, Caroline S. Fox. "Cross-Sectional Associations Bet ween Abdominal and Thoracic Adipose Tissue Compartments and Adiponectin and Resistin in the Framingham Heart Study" Diabetes Care 32(5): 903-908. (2009) en_US
dc.identifier.issn 1935-5548 en_US
dc.identifier.uri http://hdl.handle.net/2144/2632
dc.description.abstract OBJECTIVE: To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and cardiometabolic risk factors. RESEARCH DESIGN AND METHODS: Participants from the Framingham Heart Study offspring cohort (n = 916, 55% women; mean age 59 years) free of cardiovascular disease underwent computed tomography measurement of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), pericardial fat, and intrathoracic fat volumes and assays of circulating adiponectin and resistin. RESULTS: VAT, SAT, pericardial fat, and intrathoracic fat were negatively correlated with adiponectin (r = −0.19 to −0.34, P < 0.001 [women]; r = −0.15 to −0.26, P < 0.01 [men] except SAT) and positively correlated with resistin (r = 0.16–0.21, P < 0.001 [women]; r = 0.11–0.14, P < 0.05 [men] except VAT). VAT increased the multivariable model R2 for adiponectin from 2–4% to 10–13% and for resistin from 3–4% to 3–6%. Adjustment for adipokines did not fully attenuate associations between VAT, SAT, and cardiometabolic risk factors. CONCLUSIONS: Adiponectin and resistin are correlated with fat depots cross-sectionally, but none of the adipokines can serve as surrogates for the fat depots. Relations between VAT, SAT, and cardiometabolic risk factors were not fully explained by adiponectin or resistin concentrations. en_US
dc.description.sponsorship National Insitute's of Health National Heart, Lung, and Blood Institute’s Framingham Heart Study (N01-HC-25195); the National Institutes of Health; National Center for Research Resources; General Clinical Research Centers Program (M01-RR-01066); Career Development Award from the American Diabetes Association; National Institute of Diabetes and Digestive and Kidney Diseases (K24 DK080140, RO1 DK080739); National Heart, Lung, and Blood Institute, National Institutes of Health (2K24HL04334) en_US
dc.language.iso en en_US
dc.publisher American Diabetes Association en_US
dc.title Cross-Sectional Associations Bet ween Abdominal and Thoracic Adipose Tissue Compartments and Adiponectin and Resistin in the Framingham Heart Study en_US
dc.type article en_US
dc.identifier.doi 10.2337/dc08-1733 en_US
dc.identifier.pubmedid 19223612 en_US
dc.identifier.pmcid 2671095 en_US


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