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Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study

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dc.contributor.author Perlstein, Todd en_US
dc.contributor.author Weuve, Jennifer en_US
dc.contributor.author Schwartz, Joel en_US
dc.contributor.author Sparrow, David en_US
dc.contributor.author Wright, Robert en_US
dc.contributor.author Litonjua, Augusto en_US
dc.contributor.author Nie, Huiling en_US
dc.contributor.author Hu, Howard en_US
dc.date.accessioned 2012-01-09T14:19:05Z
dc.date.available 2012-01-09T14:19:05Z
dc.date.issued 2007-12 en_US
dc.identifier.citation Perlstein, Todd, Jennifer Weuve, Joel Schwartz, David Sparrow, Robert Wright, Augusto Litonjua, Huiling Nie, Howard Hu. "Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study" Environmental Health Perspectives 115(12): 1696-1700. (2007) en_US
dc.identifier.issn en_US
dc.identifier.uri http://hdl.handle.net/2144/2741
dc.description.abstract BACKGROUND. Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote functional and structural vascular disease. OBJECTIVES. We tested the hypothesis that cumulative community-level lead exposure, measured with K-X-ray fluorescence, is associated with pulse pressure in a cohort of adult men. METHODS AND RESULTS. In a cross-sectional analysis of 593 men not treated with antihypertensive medication, tibia lead was positively associated with pulse pressure (p < 0.001). Adjusting for age, race, diabetes, family history of hypertension, education, waist circumference, alcohol intake, smoking history, height, heart rate, fasting glucose, and total cholesterol-to-HDL ratio, increasing quintiles of tibia lead remained associated with increased pulse pressure (ptrend = 0.02). Men with tibia lead above the median (19.0 μg/g) had, on average, a 4.2-mmHg (95% confidence interval, 1.9-6.5) higher pulse pressure than men with tibia lead level below the median. In contrast, blood lead level was not associated with pulse pressure. CONCLUSIONS. These data indicate that lead exposure may contribute to the observed increase in pulse pressure that occurs with aging in industrialized societies. Lead accumulation may contribute to arterial aging, perhaps providing mechanistic insight into the observed association of low-level lead exposure with cardiovascular mortality. en_US
dc.description.sponsorship National Institutes of Health (T32 HL007609, R01-ES05257, P20-MD000501, P42-ES05947, GCRC M01-RR02635, ES03918-02); United States Department of Veterans Affairs; ABIOMED, Inc. en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.subject Aging en_US
dc.subject Epidemiology en_US
dc.subject Human en_US
dc.subject Lead exposure en_US
dc.subject Pulse pressure en_US
dc.title Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.10350 en_US
dc.identifier.pubmedid 18087585 en_US
dc.identifier.pmcid 2137129 en_US


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