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Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study

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dc.contributor.author Peters, Junenette L. en_US
dc.contributor.author Kubzansky, Laura en_US
dc.contributor.author McNeely, Eileen en_US
dc.contributor.author Schwartz, Joel en_US
dc.contributor.author Spiro, Avron en_US
dc.contributor.author Sparrow, David en_US
dc.contributor.author Wright, Robert O. en_US
dc.contributor.author Nie, Huiling en_US
dc.contributor.author Hu, Howard en_US
dc.date.accessioned 2012-01-09T14:19:06Z
dc.date.available 2012-01-09T14:19:06Z
dc.date.issued 2007-08 en_US
dc.identifier.citation Peters, Junenette L., Laura Kubzansky, Eileen McNeely, Joel Schwartz, Avron Spiro, David Sparrow, Robert O. Wright, Huiling Nie, Howard Hu. "Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study" Environmental Health Perspectives 115(8): 1154-1159. (2007) en_US
dc.identifier.uri http://hdl.handle.net/2144/2745
dc.description.abstract BACKGROUND. Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. OBJECTIVES. We examined whether psychological stress modifies the impact of cumulative lead exposure (measured as bone lead levels) on hypertension and blood pressure in Boston-area community-exposed men participating in the Normative Aging Study. METHODS. We evaluated the modifying effect of stress on lead exposure on baseline hypertension status (513 participants) and on blood pressure in those without hypertension (237 participants), cross-sectionally. In baseline nonhypertensives, we examined the same risk factors in relation to prospective risk of developing hypertension. RESULTS. Cross-sectional analysis revealed a positive interaction between stress and tibia lead on systolic blood pressure, after adjusting for age, body mass index, family history of high blood pressure, education, smoking, alcohol consumption, physical activity, and nutritional factors. In prospective multivariate analyses, high stress also modified the effect of tibia lead and patella lead on the risk of developing hypertension. Those reporting high stress had 2.66 [95% confidence interval (CI), 1.43-4.95] times the risk of developing hypertension per standard deviation increase in tibia lead and had 2.64 (95% CI, 1.42-4.92) times the risk per standard deviation increase in patella lead. CONCLUSION. To our knowledge, these are the first analyses to look at interactive effects of stress and lead on hypertension in humans. These results suggest that the effect of lead on hypertension is most pronounced among highly stressed individuals, independent of demographic and behavioral risk factors. en_US
dc.description.sponsorship National Institutes of Health (R01-ES05257, P20-MD000501, P42-ES05947, GCRC M01-RR02635, ES03918-02); United States Department of Veterans Affairs en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.subject Blood pressure en_US
dc.subject Bone lead en_US
dc.subject Hypertension en_US
dc.subject Psychosocial stress en_US
dc.title Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.10002 en_US
dc.identifier.pubmedid 17687441 en_US
dc.identifier.pmcid 1940093 en_US


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