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Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter

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dc.contributor.author Wilker, Elissa en_US
dc.contributor.author Mittleman, Murray A. en_US
dc.contributor.author Litonjua, Augusto A. en_US
dc.contributor.author Poon, Audrey en_US
dc.contributor.author Baccarelli, Andrea en_US
dc.contributor.author Suh, Helen en_US
dc.contributor.author Wright, Robert O. en_US
dc.contributor.author Sparrow, David en_US
dc.contributor.author Vokonas, Pantel en_US
dc.contributor.author Schwartz, Joel en_US
dc.date.accessioned 2012-01-09T14:19:59Z
dc.date.available 2012-01-09T14:19:59Z
dc.date.issued 2009-06 en_US
dc.identifier.citation Wilker, Elissa, Murray A. Mittleman, Augusto A. Litonjua, Audrey Poon, Andrea Baccarelli, Helen Suh, Robert O. Wright, David Sparrow, Pantel Vokonas, Joel Schwartz. "Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter" Environmental Health Perspectives 117(6): 935-940. (2009) en_US
dc.identifier.issn 1552-9924 en_US
dc.identifier.uri http://hdl.handle.net/2144/2750
dc.description.abstract BACKGROUND. Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation. OBJECTIVE. We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) and in diastolic blood pressure (ΔDBP) and that this effect is modified by genes thought to be related to chronic lung disease. METHODS. We measured blood pressure in participants every 3-5 years. ΔSBP and ΔDBP were calculated as sitting minus standing SBP and DBP. We averaged PM2.5 over 48 hr before study visits and analyzed 202 single nucleotide polymorphisms (SNPs) in 25 genes. To address multiple comparisons, data were stratified into a split sample. In the discovery cohort, the effects of SNP x PM2.5 interactions on ΔSBP and ΔDBP were analyzed using mixed models with subject-specific random intercepts. We defined positive outcomes as p < 0.1 for the interaction; we analyzed only these SNPs in the replicate cohort and confirmed them if p < 0.025 with the same sign. Confirmed associations were analyzed within the full cohort in models adjusted for anthropometric and lifestyle factors. RESULTS. Nine hundred forty-five participants were included in our analysis. One interaction with rs9568232 in PHD finger protein 11 (PHF11) was associated with greater ΔDBP. Interactions with rs1144393 in matrix metalloprotease 1 (MMP1) and rs16930692, rs7955200, and rs10771283 in inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) were associated with significantly greater ΔSBP. Because SNPs associated with ΔSBP in our analysis are in genes along the renin-angiotensin pathway, we then examined medications affecting that pathway and observed significant interactions for angiotensin receptor blockers but not angiotensin-converting enzyme inhibitors with PM2.5. CONCLUSIONS. PM2.5 influences blood pressure and autonomic function. This effect is modified by genes and drugs that also act along this pathway. en_US
dc.description.sponsorship National Institute of Environmental Health Sciences (T32 ES07069, ES0002, ES015172-01, ES014663, P01 ES09825); United States Environmental Protection Agency (R827353, R832416); National Institutes of Health/National Institute of Aging (AG027014); United States Department of Veterans Affairs; Massachusetts Veterans Epidemiology Research and Information Center en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.rights This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. en_US
dc.subject Aging and susceptible populations en_US
dc.subject Blood pressure en_US
dc.subject Environmental epidemiology en_US
dc.subject Gene-environment interaction en_US
dc.subject Particulate matter en_US
dc.title Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.0800279 en_US
dc.identifier.pubmedid 19590686 en_US
dc.identifier.pmcid 2702409 en_US


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