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Traffic-Related Air Pollution and QT Interval: Modification by Diabetes, Obesity, and Oxidative Stress Gene Polymorphisms in the Normative Aging Study

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dc.contributor.author Baja, Emmanuel S. en_US
dc.contributor.author Schwartz, Joel D. en_US
dc.contributor.author Wellenius, Gregory A. en_US
dc.contributor.author Coull, Brent A. en_US
dc.contributor.author Zanobetti, Antonella en_US
dc.contributor.author Vokonas, Pantel S. en_US
dc.contributor.author Suh, Helen H. en_US
dc.date.accessioned 2012-01-09T14:20:01Z
dc.date.available 2012-01-09T14:20:01Z
dc.date.issued 2010-06 en_US
dc.identifier.citation Baja, Emmanuel S., Joel D. Schwartz, Gregory A. Wellenius, Brent A. Coull, Antonella Zanobetti, Pantel S. Vokonas, Helen H. Suh. "Traffic-Related Air Pollution and QT Interval: Modification by Diabetes, Obesity, and Oxidative Stress Gene Polymorphisms in the Normative Aging Study" Environmental Health Perspectives 118(6): 840-846. (2010) en_US
dc.identifier.issn 1552-9924 en_US
dc.identifier.uri http://hdl.handle.net/2144/2754
dc.description.abstract BACKGROUND. Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure. OBJECTIVES. We examined the effects of air pollutants on heart-rate-corrected QT interval (QTc), an electrocardiographic marker of ventricular repolarization, and whether these associations were modified by participant characteristics and genetic polymorphisms related to oxidative stress. METHODS. We studied repeated measurements of QTc on 580 men from the Veterans Affairs Normative Aging Study (NAS) using mixed-effects models with random intercepts. We fitted a quadratic constrained distributed lag model to estimate the cumulative effect on QTc of ambient air pollutants including fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5), ozone (O3), black carbon (BC), nitrogen dioxide (NO2), carbon monoxide (CO), and sulfur dioxide (SO2) concentrations during the 10 hr before the visit. We genotyped polymorphisms related to oxidative stress and analyzed pollution-susceptibility score interactions using the genetic susceptibility score (GSS) method. RESULTS. Ambient traffic pollutant concentrations were related to longer QTc. An interquartile range (IQR) change in BC cumulative during the 10 hr before the visit was associated with increased QTc [1.89 msec change; 95% confidence interval (CI), -0.16 to 3.93]. We found a similar association with QTc for an IQR change in 1-hr BC that occurred 4 hr before the visit (2.54 msec change; 95% CI, 0.28-4.80). We found increased QTc for IQR changes in NO2 and CO, but the change was statistically insignificant. In contrast, we found no association between QTc and PM2.5, SO2, and O3. The association between QTc and BC was stronger among participants who were obese, who had diabetes, who were nonsmokers, or who had higher GSSs. CONCLUSIONS. Traffic-related pollutants may increase QTc among persons with diabetes, persons who are obese, and nonsmoking elderly individuals; the number of genetic variants related to oxidative stress increases this effect. en_US
dc.description.sponsorship National Institute of Environmental Health Sciences (ES014663-01A2, P01 ES09825); United States Environmental Protection Agency (R827353, R83241601) en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.rights This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. en_US
dc.subject Air pollution en_US
dc.subject Diabetes en_US
dc.subject Distributed lags en_US
dc.subject Genes en_US
dc.subject Obesity en_US
dc.subject Oxidative stress en_US
dc.subject QT interval en_US
dc.subject Smoking en_US
dc.subject Traffic en_US
dc.title Traffic-Related Air Pollution and QT Interval: Modification by Diabetes, Obesity, and Oxidative Stress Gene Polymorphisms in the Normative Aging Study en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.0901396 en_US
dc.identifier.pubmedid 20194081 en_US
dc.identifier.pmcid 2898862 en_US


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