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Genome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Network

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dc.contributor.author Linghu, Bolan en_US
dc.contributor.author Snitkin, Evan S en_US
dc.contributor.author Hu, Zhenjun en_US
dc.contributor.author Xia, Yu en_US
dc.contributor.author DeLisi, Charles en_US
dc.date.accessioned 2012-01-09T14:44:43Z
dc.date.available 2012-01-09T14:44:43Z
dc.date.copyright 2009 en_US
dc.date.issued 2009-09-03 en_US
dc.identifier.citation Linghu, Bolan, Evan S Snitkin, Zhenjun Hu, Yu Xia, Charles DeLisi. "Genome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Network" Genome Biology 10(9):R91. (2009) en_US
dc.identifier.issn 1465-6914 en_US
dc.identifier.uri http://hdl.handle.net/2144/2786
dc.description.abstract An evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes. We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are supported by epidemiology, but with no previous genetic basis. Such associations can drive novel hypotheses on molecular mechanisms of diseases and therapies. en_US
dc.description.sponsorship National Institutes of Health (R01 RR022971); RhRMA Foundation (Research Starter Grant) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2009 Linghu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Genome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Network en_US
dc.type article en_US
dc.identifier.doi 10.1186/gb-2009-10-9-r91 en_US
dc.identifier.pubmedid 19728866 en_US
dc.identifier.pmcid 2768980 en_US


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Copyright 2009 Linghu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright 2009 Linghu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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