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Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico Border

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dc.contributor.author Missmer, Stacey A. en_US
dc.contributor.author Suarez, Lucina en_US
dc.contributor.author Felkner, Marilyn en_US
dc.contributor.author Wang, Elaine en_US
dc.contributor.author Merrill, Alfred H. en_US
dc.contributor.author Rothman, Kenneth J. en_US
dc.contributor.author Hendricks, Katherine A. en_US
dc.date.accessioned 2012-01-09T15:09:28Z
dc.date.available 2012-01-09T15:09:28Z
dc.date.issued 2006-02 en_US
dc.identifier.citation Missmer, Stacey A., Lucina Suarez, Marilyn Felkner, Elaine Wang, Alfred H. Merrill, Kenneth J. Rothman, Katherine A. Hendricks. "Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico Border" Environmental Health Perspectives 114(2): 237-241. (2005) en_US
dc.identifier.uri http://hdl.handle.net/2144/2810
dc.description.abstract Along the Texas-Mexico border, the prevalence of neural tube defects (NTDs) among Mexican-American women doubled during 1990-1991. The human outbreak began during the same crop year as epizootics attributed to exposure to fumonisin, a mycotoxin that often contaminates corn. Because Mexican Americans in Texas consume large quantities of corn, primarily in the form of tortillas, they may be exposed to high levels of fumonisins. We examined whether or not maternal exposure to fumonisins increases the risk of NTDs in offspring using a population-based case-control study. We estimated fumonisin exposure from a postpartum sphinganine:sphingosine (sa:so) ratio, a biomarker for fumonisin exposure measured in maternal serum, and from maternal recall of periconceptional corn tortilla intake. After adjusting for confounders, moderate (301-400) compared with low (≤100) consumption of tortillas during the first trimester was associated with increased odds ratios (ORs) of having an NTD-affected pregnancy (OR = 2.4; 95% confidence interval, 1.1-5.3). No increased risks were observed at intakes higher than 400 tortillas (OR = 0.8 for 401-800, OR = 1.0 for > 800). Based on the postpartum sa:so ratio, increasing levels of fumonisin exposure were associated with increasing ORs for NTD occurrences, except for the highest exposure category (sa:so > 0.35). Our findings suggest that fumonisin exposure increases the risk of NTD, proportionate to dose, up to a threshold level, at which point fetal death may be more likely to occur. These results also call for population studies that can more directly measure individual fumonisin intakes and assess effects on the developing embryo. en_US
dc.description.sponsorship Center for Disease Control (U85/CCU608761-05); Texas Birth Defects Research Center (U50/CCU613232); P. Blackshear (National Institute of Environmental Health Sciences) en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.subject Case-control study en_US
dc.subject Corn en_US
dc.subject Fumonisins en_US
dc.subject Mexican Americans en_US
dc.subject Mycotoxins en_US
dc.subject Neural tube defects en_US
dc.title Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico Border en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.8221 en_US
dc.identifier.pubmedid 16451860 en_US
dc.identifier.pmcid 1367837 en_US


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