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Interaction of Stress, Lead Burden, and Age on Cognition in Older Men: The VA Normative Aging Study

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dc.contributor.author Peters, Junenette L. en_US
dc.contributor.author Weisskopf, Marc G. en_US
dc.contributor.author Spiro, Avron en_US
dc.contributor.author Schwartz, Joel en_US
dc.contributor.author Sparrow, David en_US
dc.contributor.author Nie, Huiling en_US
dc.contributor.author Hu, Howard en_US
dc.contributor.author Wright, Robert O. en_US
dc.contributor.author Wright, Rosalind J. en_US
dc.date.accessioned 2012-01-09T15:09:28Z
dc.date.available 2012-01-09T15:09:28Z
dc.date.issued 2010-04 en_US
dc.identifier.citation Peters, Junenette L., Marc G. Weisskopf, Avron Spiro, Joel Schwartz, David Sparrow, Huiling Nie, Howard Hu, Robert O. Wright, Rosalind J. Wright. "Interaction of Stress, Lead Burden, and Age on Cognition in Older Men: The VA Normative Aging Study" Environmental Health Perspectives 118 (4): 505-510. (2009) en_US
dc.identifier.issn 1552-9924 en_US
dc.identifier.uri http://hdl.handle.net/2144/2812
dc.description.abstract BACKGROUND. Low-level exposure to lead and to chronic stress may independently influence cognition. However, the modifying potential of psychosocial stress on the neurotoxicity of lead and their combined relationship to aging-associated decline have not been fully examined. OBJECTIVES. We examined the cross-sectional interaction between stress and lead exposure on Mini-Mental State Examination (MMSE) scores among 811 participants in the Normative Aging Study, a cohort of older U.S. men. METHODS. We used two self-reported measures of stress appraisal-a self-report of stress related to their most severe problem and the Perceived Stress Scale (PSS). Indices of lead exposure were blood lead and bone (tibia and patella) lead. RESULTS. Participants with higher self-reported stress had lower MMSE scores, which were adjusted for age, education, computer experience, English as a first language, smoking, and alcohol intake. In multivariable-adjusted tests for interaction, those with higher PSS scores had a 0.57-point lower (95% confidence interval, -0.90 to 0.24) MMSE score for a 2-fold increase in blood lead than did those with lower PSS scores. In addition, the combination of high PSS scores and high blood lead categories on one or both was associated with a 0.05-0.08 reduction on the MMSE for each year of age compared with those with low PSS score and blood lead level (p < 0.05). CONCLUSIONS. Psychological stress had an independent inverse association with cognition and also modified the relationship between lead exposure and cognitive performance among older men. Furthermore, high stress and lead together modified the association between age and cognition. en_US
dc.description.sponsorship National Institutes of Health (R01ES07821, R01HL080674, R01HL080674-02S1, R01ES013744, ES05257-06A1, P20MD000501, P42ES05947, ES03918-02); National Center for Research Resources General Clinical Research Center (M01RR02635); Leaves of Grass Foundation; United States Department of Veterans Affairs en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.rights This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. en_US
dc.subject Aging en_US
dc.subject Blood en_US
dc.subject Bone en_US
dc.subject Lead en_US
dc.subject Cognition en_US
dc.subject Psychological stress en_US
dc.title Interaction of Stress, Lead Burden, and Age on Cognition in Older Men: The VA Normative Aging Study en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.0901115 en_US
dc.identifier.pubmedid 20064786 en_US
dc.identifier.pmcid 2854727 en_US


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