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Triple-Negative Breast Cancers are Increased in Black Women Regardless of Age or Body Mass Index

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dc.contributor.author Stead, Lesley A en_US
dc.contributor.author Lash, Timothy L en_US
dc.contributor.author Sobieraj, Jerome E en_US
dc.contributor.author Chi, Dorcas D en_US
dc.contributor.author Westrup, Jennifer L en_US
dc.contributor.author Charlot, Marjory en_US
dc.contributor.author Blanchard, Rita A en_US
dc.contributor.author Lee, John C en_US
dc.contributor.author King, Thomas C en_US
dc.contributor.author Rosenberg, Carol L en_US
dc.date.accessioned 2012-01-09T20:54:52Z
dc.date.available 2012-01-09T20:54:52Z
dc.date.copyright 2009 en_US
dc.date.issued 2009-3-25 en_US
dc.identifier.citation Stead, Lesley A, Timothy L Lash, Jerome E Sobieraj, Dorcas D Chi, Jennifer L Westrup, Marjory Charlot, Rita A Blanchard, John C Lee, Thomas C King, Carol L Rosenberg. "Triple-negative breast cancers are increased in black women regardless of age or body mass index" Breast Cancer Research: BCR 11(2):R18. (2009) en_US
dc.identifier.issn 1465-542X en_US
dc.identifier.uri http://hdl.handle.net/2144/2914
dc.description.abstract INTRODUCTION. We investigated clinical and pathologic features of breast cancers (BC) in an unselected series of patients diagnosed in a tertiary care hospital serving a diverse population. We focused on triple-negative (Tneg) tumours (oestrogen receptor (ER), progesterone receptor (PR) and HER2 negative), which are associated with poor prognosis. METHODS. We identified female patients with invasive BC diagnosed between 1998 and 2006, with data available on tumor grade, stage, ER, PR and HER2 status, and patient age, body mass index (BMI) and self-identified racial/ethnic group. We determined associations between patient and tumour characteristics using contingency tables and multivariate logistic regression. RESULTS. 415 cases were identified. Patients were racially and ethnically diverse (born in 44 countries, 36% white, 43% black, 10% Hispanic and 11% other). 47% were obese (BMI > 30 kg/m2). 72% of tumours were ER+ and/or PR+, 20% were Tneg and 13% were HER2+. The odds of having a Tneg tumour were 3-fold higher (95% CI 1.6, 5.5; p = 0.0001) in black compared with white women. Tneg tumours were equally common in black women diagnosed before and after age 50 (31% vs 29%; p = NS), and who were obese and non-obese (29% vs 31%; p = NS). Considering all patients, as BMI increased, the proportion of Tneg tumours decreased (p = 0.08). CONCLUSIONS. Black women of diverse background have 3-fold more Tneg tumours than non-black women, regardless of age and BMI. Other factors must determine tumour subtype. The higher prevalence of Tneg tumours in black women in all age and weight categories likely contributes to black women's unfavorable breast cancer prognosis. en_US
dc.description.sponsorship LaPann Fund; Research Enhancement Fund en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2009 Stead et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Triple-Negative Breast Cancers are Increased in Black Women Regardless of Age or Body Mass Index en_US
dc.type article en_US
dc.identifier.doi 10.1186/bcr2242 en_US
dc.identifier.pubmedid 19320967 en_US
dc.identifier.pmcid 2688946 en_US


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Copyright 2009 Stead et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright 2009 Stead et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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