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Intermittent Preventive Treatment with Sulphadoxine-Pyrimethamine Is Effective in Preventing Maternal and Placental Malaria in Ibadan, South-Western Nigeria

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dc.contributor.author Falade, Catherine O en_US
dc.contributor.author Yusuf, Bidemi O en_US
dc.contributor.author Fadero, Francis F en_US
dc.contributor.author Mokuolu, Olugbenga A en_US
dc.contributor.author Hamer, Davidson H en_US
dc.contributor.author Salako, Lateef A en_US
dc.date.accessioned 2012-01-09T20:58:39Z
dc.date.available 2012-01-09T20:58:39Z
dc.date.copyright 2007 en_US
dc.date.issued 2007-7-6 en_US
dc.identifier.citation Falade, Catherine O, Bidemi O Yusuf, Francis F Fadero, Olugbenga A Mokuolu, Davidson H Hamer, Lateef A Salako. "Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria" Malaria Journal 6:88. (2007) en_US
dc.identifier.issn 1475-2875 en_US
dc.identifier.uri http://hdl.handle.net/2144/2946
dc.description.abstract BACKGROUND Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy in endemic areas. This study sets out to evaluate the effectiveness of IPT-SP in the prevention of maternal and placental malaria in parturient mothers in Ibadan, Nigeria, where the risk of malaria is present all year round. METHOD During a larger study evaluating the epidemiology of congenital malaria, the effect of malaria prophylaxis was examined in 983 parturient mothers. Five hundred and ninety eight mothers (60.8%) received IPT-SP, 214 (21.8%) received pyrimethamine (PYR) and 171 (17.4%) did not take any chemoprophylactic agent (NC). RESULTS The prevalence of maternal parasitaemia in the IPT-SP, PYR and NC groups was 10.4%, 15.9% and 17% respectively (p = 0.021). The prevalence of placental parasitaemia was 10.5% in the IPT-SP, 16.8% PYR and 17% NC groups, respectively (p = 0.015). The prevalence of maternal anaemia (haematocrit <30%) was 5.7% vs. 8.9% vs. 13.4% among the IPT-SP, PYR and NC groups respectively (p <0.0001) while that of pre-term delivery (GA <37 weeks) was 10.5%, 19.2% and 25.3% among IPT-SP, PYR and NC groups respectively (p <0.0001). Babies born to mothers in the IPT-SP, PYR and NC groups had mean birth weights of 3204 ± 487.16, 3075 ± 513.24 and 3074 ± 505.92 respectively (ρ <0.0001). There was a trend towards a lower proportion of low birth weight babies in the IPT-SP group (p = 0.095). CONCLUSION IPT-SP is effective in preventing maternal and placental malaria as well as improving pregnancy outcomes among parturient women in Ibadan, Nigeria. The implementation of the recently adopted IPT-SP strategy should be pursued with vigour as it holds great promise for reducing the burden of malaria in pregnancy in Nigeria. en_US
dc.description.sponsorship Cooperative Agreement between Boston University and the Office of Health and Nutrition of the United States Agency for International Development en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2007 Falade et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Intermittent Preventive Treatment with Sulphadoxine-Pyrimethamine Is Effective in Preventing Maternal and Placental Malaria in Ibadan, South-Western Nigeria en_US
dc.type article en_US
dc.identifier.doi 10.1186/1475-2875-6-88 en_US
dc.identifier.pubmedid 17617910 en_US
dc.identifier.pmcid 1941736 en_US


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Copyright 2007 Falade et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright 2007 Falade et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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