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Effects of Revised Diagnostic Recommendations on Malaria Treatment Practices across Age Groups in Kenya

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dc.contributor.author Zurovac, D en_US
dc.contributor.author Njogu, J en_US
dc.contributor.author Akhwale, W en_US
dc.contributor.author Hamer, D H en_US
dc.contributor.author Larson, B A en_US
dc.contributor.author Snow, R W en_US
dc.date.accessioned 2012-01-09T21:04:10Z
dc.date.available 2012-01-09T21:04:10Z
dc.date.issued 2008-06 en_US
dc.identifier.citation Zurovac, D, J Njogu, W Akhwale, D H Hamer, B A Larson, R W Snow. "Effects of revised diagnostic recommendations on malaria treatment practices across age groups in Kenya" Tropical Medicine & International Health 13(6): 784-787. (2008) en_US
dc.identifier.issn 1365-3156 en_US
dc.identifier.uri http://hdl.handle.net/2144/2993
dc.description.abstract OBJECTIVE. The recent change of treatment policy for uncomplicated malaria from sulfadoxine-pyrime-thamine to artemether-lumefantrine (AL) in Kenya was accompanied by revised malaria diagnosis recommendations promoting presumptive antimalarial treatment in young children and parasitological diagnosis in patients 5 years and older. We evaluated the impact of these age-specific recommendations on routine malaria treatment practices 4-6 months after AL treatment was implemented. METHODS. Cross-sectional, cluster sample survey using quality-of-care assessment methods in all government facilities in four Kenyan districts. Analysis was restricted to the 64 facilities with malaria diagnostics and AL available on the survey day. Main outcome measures were antimalarial treatment practices for febrile patients stratified by age, use of malaria diagnostic tests, and test result. RESULTS. Treatment practices for 706 febrile patients (401 young children and 305 patients =5 years) were evaluated. 43.0% of patients =5 years and 25.9% of children underwent parasitological malaria testing (87% by microscopy). AL was prescribed for 79.7% of patients =5 years with positive test results, for 9.7% with negative results and for 10.9% without a test. 84.6% of children with positive tests, 19.2% with negative tests, and 21.6% without tests were treated with AL. At least one antimalarial drug was prescribed for 75.0% of children and for 61.3% of patients =5 years with a negative test result. CONCLUSIONS. Despite different recommendations for patients below and above 5 years of age, malaria diagnosis and treatment practices were similar in the two age groups. Parasitological diagnosis was under-used in older children and adults, and young children were still tested. Use of AL was low overall and alternative antimalarials were commonly prescribed; but AL prescribing largely followed the results of malaria tests. Malaria diagnosis recommendations differing between age groups appear complex to implement; further strengthening of diagnosis and treatment practices under AL policy is required. en_US
dc.description.sponsorship The Wellcome Trust; the Kenya Medical Research Institute; Novartis Pharma en_US
dc.language.iso en en_US
dc.publisher Blackwell Publishing Ltd en_US
dc.subject Malaria en_US
dc.subject Diagnostics en_US
dc.subject Artemether-lumefantrine en_US
dc.subject Guidelines en_US
dc.subject Kenya en_US
dc.title Effects of Revised Diagnostic Recommendations on Malaria Treatment Practices across Age Groups in Kenya en_US
dc.type article en_US
dc.identifier.doi 10.1111/j.1365-3156.2008.02072.x en_US
dc.identifier.pubmedid 18482078 en_US
dc.identifier.pmcid 2592476 en_US


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