OpenBU

Linking Cellular Mechanisms to Behavior: Entorhinal Persistent Spiking and Membrane Potential Oscillations May Underlie Path Integration, Grid Cell Firing, and Episodic Memory

OpenBU

Show simple item record

dc.contributor.author Hasselmo, Michael E. en_US
dc.contributor.author Brandon, Mark P. en_US
dc.date.accessioned 2012-01-11T17:18:52Z
dc.date.available 2012-01-11T17:18:52Z
dc.date.copyright 2008 en_US
dc.date.issued 2008-7-21 en_US
dc.identifier.citation Hasselmo, Michael E., Mark P. Brandon. "Linking Cellular Mechanisms to Behavior: Entorhinal Persistent Spiking and Membrane Potential Oscillations May Underlie Path Integration, Grid Cell Firing, and Episodic Memory" Neural Plasticity 2008:658323. en_US
dc.identifier.issn 1687-5443 en_US
dc.identifier.uri http://hdl.handle.net/2144/3158
dc.description.abstract The entorhinal cortex plays an important role in spatial memory and episodic memory functions. These functions may result from cellular mechanisms for integration of the afferent input to entorhinal cortex. This article reviews physiological data on persistent spiking and membrane potential oscillations in entorhinal cortex then presents models showing how both these cellular mechanisms could contribute to properties observed during unit recording, including grid cell firing, and how they could underlie behavioural functions including path integration. The interaction of oscillations and persistent firing could contribute to encoding and retrieval of trajectories through space and time as a mechanism relevant to episodic memory. en_US
dc.description.sponsorship Silvio O. Conte Center (NIMH MH71702, MH60450); National Institute of Mental Health Research (MH60013, MH61492); National Science Foundation (SLC SBE 0354378); National Institute of Drug Abuse (DA16454). en_US
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.rights Copyright 2008 M. E. Hasselmo and M. P. Brandon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.title Linking Cellular Mechanisms to Behavior: Entorhinal Persistent Spiking and Membrane Potential Oscillations May Underlie Path Integration, Grid Cell Firing, and Episodic Memory en_US
dc.type article en_US
dc.identifier.doi 10.1155/2008/658323 en_US
dc.identifier.pubmedid 18670635 en_US
dc.identifier.pmcid 2480478 en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search OpenBU


Browse

Deposit Materials

Statistics