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Longitudinal and Age Trends of Metabolic Syndrome and Its Risk Factors: The Family Heart Study

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dc.contributor.author Kraja, Aldi T en_US
dc.contributor.author Borecki, Ingrid B en_US
dc.contributor.author North, Kari en_US
dc.contributor.author Tang, Weihong en_US
dc.contributor.author Myers, Richard H en_US
dc.contributor.author Hopkins, Paul N en_US
dc.contributor.author Arnett, Donna en_US
dc.contributor.author Corbett, Jonathan en_US
dc.contributor.author Adelman, Avril en_US
dc.contributor.author Province, Michael A en_US
dc.date.accessioned 2012-01-11T21:09:07Z
dc.date.available 2012-01-11T21:09:07Z
dc.date.copyright 2006 en_US
dc.date.issued 2006-12-5 en_US
dc.identifier.citation Kraja, Aldi T, Ingrid B Borecki, Kari North, Weihong Tang, Richard H Myers, Paul N Hopkins, Donna Arnett, Jonathan Corbett, Avril Adelman, Michael A Province. "Longitudinal and age trends of metabolic syndrome and its risk factors: The Family Heart Study" Nutrition & Metabolism 3:41. (2006) en_US
dc.identifier.issn 1743-7075 en_US
dc.identifier.uri http://hdl.handle.net/2144/3182
dc.description.abstract BACKGROUND. We report longitudinal changes in the metabolic syndrome (MetS) in 2,458 participants from 480 families in the Family Heart Study. Participants were examined between 1994–96 (FHS-T1) and 2002–03 (FHS-T2), about 7.4 years apart. Additionally, the impact of medication on estimates of MetS prevalence, and associations of MetS with prevalent coronary heart disease (CHD) and type 2 diabetes (T2D) were studied. METHODS. Three definitions for MetS prevalence were considered. One represented the original (o) National Cholesterol Education Program (NCEP) MetS criteria. Two others considered the confounding of medications effects, respectively (m) lipid medications constituted a categorical diagnostic criterion for lipids variables, and (c) lipids and blood pressure variables were corrected with average clinical trials medications effects. Logistic regression of MetS on CHD and T2D, as well as the trend analysis of MetS by age, were performed. RESULTS. MetS increased from 17.1% in FHS-T1(o) to 28.8% in FHS-T2(o); from 19.7% in FHS-T1(m) to 42.5% in FHS-T2(m); and from 18.4% in FHS-T1(c) to 33.6% in FHS-T2(c). While we observed adverse changes in all risk factors, the greatest increase was for waist circumference (25%). The percentages of MetS were about 2 to almost 3 times higher in ages 50 years and older than in younger ages. The odds of having prevalent CHD were about 2.5 times higher in the subjects classified with MetS than without. CONCLUSION. MetS percentages increased noticeably longitudinally and cross-sectionally with older age. These conclusions were reached with and without considering medication use, but correcting risk factors for medications use affects the MetS prevalence estimates. As found in other studies, MetS was associated with increased odds for prevalent CHD. en_US
dc.description.sponsorship National Heart, Lung, and Blood Institute (U01 HL56563, U01 HL56564, U01 HL56565, U01 HL56566, U01 HL56567, U01 HL56568, U01 HL56569, 5K01-HL70444). en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2006 Kraja et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Longitudinal and Age Trends of Metabolic Syndrome and Its Risk Factors: The Family Heart Study en_US
dc.type article en_US
dc.identifier.doi 10.1186/1743-7075-3-41 en_US
dc.identifier.pubmedid 17147796 en_US
dc.identifier.pmcid 1697811 en_US


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Copyright 2006 Kraja et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright 2006 Kraja et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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