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Modulators of Cytoskeletal Reorganization in CA1 Hippocampal Neurons Show Increased Expression in Patients at Mid-Stage Alzheimer's Disease

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dc.contributor.author Kao, Patricia F. en_US
dc.contributor.author Davis, David A. en_US
dc.contributor.author Banigan, Meredith G. en_US
dc.contributor.author Vanderburg, Charles R. en_US
dc.contributor.author Seshadri, Sudha en_US
dc.contributor.author Delalle, Ivana en_US
dc.date.accessioned 2012-01-11T21:09:08Z
dc.date.available 2012-01-11T21:09:08Z
dc.date.issued 2010-10-13 en_US
dc.identifier.citation Kao, Patricia F., David A. Davis, Meredith G. Banigan, Charles R. Vanderburg, Sudha Seshadri, Ivana Delalle. "Modulators of Cytoskeletal Reorganization in CA1 Hippocampal Neurons Show Increased Expression in Patients at Mid-Stage Alzheimer's Disease" PLoS ONE 5(10): e13337. (2010) en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/2144/3188
dc.description.abstract During the progression of Alzheimer's disease (AD), hippocampal neurons undergo cytoskeletal reorganization, resulting in degenerative as well as regenerative changes. As neurofibrillary tangles form and dystrophic neurites appear, sprouting neuronal processes with growth cones emerge. Actin and tubulin are indispensable for normal neurite development and regenerative responses to injury and neurodegenerative stimuli. We have previously shown that actin capping protein beta2 subunit, Capzb2, binds tubulin and, in the presence of tau, affects microtubule polymerization necessary for neurite outgrowth and normal growth cone morphology. Accordingly, Capzb2 silencing in hippocampal neurons resulted in short, dystrophic neurites, seen in neurodegenerative diseases including AD. Here we demonstrate the statistically significant increase in the Capzb2 expression in the postmortem hippocampi in persons at mid-stage, Braak and Braak stage (BB) III-IV, non-familial AD in comparison to controls. The dynamics of Capzb2 expression in progressive AD stages cannot be attributed to reactive astrocytosis. Moreover, the increased expression of Capzb2 mRNA in CA1 pyramidal neurons in AD BB III-IV is accompanied by an increased mRNA expression of brain derived neurotrophic factor (BDNF) receptor tyrosine kinase B (TrkB), mediator of synaptic plasticity in hippocampal neurons. Thus, the up-regulation of Capzb2 and TrkB may reflect cytoskeletal reorganization and/or regenerative response occurring in hippocampal CA1 neurons at a specific stage of AD progression. en_US
dc.description.sponsorship National Institutes of Health (T32 AG00015-21) en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights Kao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_US
dc.title Modulators of Cytoskeletal Reorganization in CA1 Hippocampal Neurons Show Increased Expression in Patients at Mid-Stage Alzheimer's Disease en_US
dc.type article en_US
dc.identifier.doi 10.1371/journal.pone.0013337 en_US
dc.identifier.pubmedid 20967212 en_US
dc.identifier.pmcid 2954170 en_US


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