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Many Sequence-Specific Chromatin Modifying Protein-Binding Motifs Show Strong Positional Preferences for Potential Regulatory Regions in the Saccharomyces Cerevisiae Genome

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dc.contributor.author Hansen, Loren en_US
dc.contributor.author Mariño-Ramírez, Leonardo en_US
dc.contributor.author Landsman, David en_US
dc.date.accessioned 2012-01-11T21:11:31Z
dc.date.available 2012-01-11T21:11:31Z
dc.date.copyright 2009 en_US
dc.date.issued 2010-01-04 en_US
dc.identifier.citation Hansen, Loren, Leonardo Mariño-Ramírez, David Landsman. "Many sequence-specific chromatin modifying protein-binding motifs show strong positional preferences for potential regulatory regions in the Saccharomyces cerevisiae genome" Nucleic Acids Research 38(6): 1772-1779. (2010) en_US
dc.identifier.issn 1362-4962 en_US
dc.identifier.uri http://hdl.handle.net/2144/3209
dc.description.abstract Initiation and regulation of gene expression is critically dependent on the binding of transcriptional regulators, which is often temporal and position specific. Many transcriptional regulators recognize and bind specific DNA motifs. The length and degeneracy of these motifs results in their frequent occurrence within the genome, with only a small subset serving as actual binding sites. By occupying potential binding sites, nucleosome placement can specify which sequence motif is available for DNA-binding regulatory factors. Therefore, the specification of nucleosome placement to allow access to transcriptional regulators whenever and wherever required is critical. We show that many DNA-binding motifs in Saccharomyces cerevisiae show a strong positional preference to occur only in potential regulatory regions. Furthermore, using gene ontology enrichment tools, we demonstrate that proteins with binding motifs that show the strongest positional preference also have a tendency to have chromatin-modifying properties and functions. This suggests that some DNA-binding proteins may depend on the distribution of their binding motifs across the genome to assist in the determination of specificity. Since many of these DNA-binding proteins have chromatin remodeling properties, they can alter the local nucleosome structure to a more permissive and/or restrictive state, thereby assisting in determining DNA-binding protein specificity. en_US
dc.description.sponsorship CORPOICA; Intramural Program of the National Library of Medicine; National Institutes of Health en_US
dc.language.iso en en_US
dc.publisher Oxford University Press en_US
dc.rights Copyright Hansen, Loren, Leonardo Mariño-Ramírez, David Landsman 2009. Published by Oxford University Press. en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.5 en_US
dc.title Many Sequence-Specific Chromatin Modifying Protein-Binding Motifs Show Strong Positional Preferences for Potential Regulatory Regions in the Saccharomyces Cerevisiae Genome en_US
dc.type article en_US
dc.identifier.doi 10.1093/nar/gkp1195 en_US
dc.identifier.pubmedid 20047965 en_US
dc.identifier.pmcid 2847247 en_US


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Copyright Hansen, Loren, Leonardo Mariño-Ramírez, David Landsman 2009. Published by Oxford University Press. Except where otherwise noted, this item's license is described as Copyright Hansen, Loren, Leonardo Mariño-Ramírez, David Landsman 2009. Published by Oxford University Press.

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