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Use of Selective Serotonin Reuptake Inhibitors and Risk of Re-Operation Due to Post-Surgical Bleeding in Breast Cancer Patients: A Danish Population-Based Cohort Study

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dc.contributor.author Gärtner, Rune en_US
dc.contributor.author Cronin-Fenton, Deirdre en_US
dc.contributor.author Hundborg, Heidi H en_US
dc.contributor.author Pedersen, Lars en_US
dc.contributor.author Lash, Timothy L en_US
dc.contributor.author Sørensen, Henrik Toft en_US
dc.contributor.author Kroman, Niels en_US
dc.date.accessioned 2012-01-11T22:21:33Z
dc.date.available 2012-01-11T22:21:33Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-1-24 en_US
dc.identifier.citation Gärtner, Rune, Deirdre Cronin-Fenton, Heidi H Hundborg, Lars Pedersen, Timothy L Lash, Henrik Toft Sørensen, Niels Kroman. "Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients: a Danish population-based cohort study" BMC Surgery 10:3. (2010) en_US
dc.identifier.issn 1471-2482 en_US
dc.identifier.uri http://hdl.handle.net/2144/3261
dc.description.abstract BACKGROUND. Selective serotonin reuptake inhibitors (SSRI) decrease platelet-function, which suggests that SSRI use may increase the risk of post-surgical bleeding. Few studies have investigated this potential association. METHODS. We conducted a population-based study of the risk of re-operation due to post-surgical bleeding within two weeks of primary surgery among Danish women with primary breast cancer. Patients were categorised according to their use of SSRI: never users, current users (SSRI prescription within 30 days of initial breast cancer surgery), and former users (SSRI prescription more than 30 days before initial breast cancer surgery). We calculated the risk of re-operation due to post-surgical bleeding within 14 days of initial surgery, and the relative risk (RR) of re-operation comparing SSRI users with never users of SSRI adjusting for potential confounders. RESULTS. 389 of 14,464 women (2.7%) were re-operated. 1592 (11%) had a history of SSRI use. Risk of re-operation was 2.6% among never users, 7.0% among current SSRI users, and 2.7% among former users. Current users thus had an increased risk of re-operation due to post-operative bleeding (adjusted relative risk = 2.3; 95% confidence interval (CI) = 1.4, 3.9) compared with never users. There was no increased risk of re-operation associated with former use of SSRI (RR = 0.93, 95% CI = 0.66, 1.3). CONCLUSIONS. Current use of SSRI is associated with an increased risk of re-operation due to bleeding after surgery for breast cancer. en_US
dc.description.sponsorship Rigshospitalet; Danish Cancer Society; Breast Friends; Lundbeck Foundation; Karen Elise Jensen Foundation; Western Danish Research Forum for Health Sciences; Aarhus University en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2010 Gärtner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Use of Selective Serotonin Reuptake Inhibitors and Risk of Re-Operation Due to Post-Surgical Bleeding in Breast Cancer Patients: A Danish Population-Based Cohort Study en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2482-10-3 en_US
dc.identifier.pubmedid 20096133 en_US
dc.identifier.pmcid 2823600 en_US


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Copyright 2010 Gärtner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright 2010 Gärtner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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