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Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age-Related Macular Degeneration

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dc.contributor.author Yi, K en_US
dc.contributor.author Mujat, M en_US
dc.contributor.author Park, B H en_US
dc.contributor.author Sun, W en_US
dc.contributor.author Miller, J W en_US
dc.contributor.author Seddon, J M en_US
dc.contributor.author Young, L H en_US
dc.contributor.author de Boer, J F en_US
dc.contributor.author Chen, T C en_US
dc.date.accessioned 2012-01-12T16:41:19Z
dc.date.available 2012-01-12T16:41:19Z
dc.date.copyright 2009 en_US
dc.date.issued 2008-12-3 en_US
dc.identifier.citation Yi, K, M Mujat, B H Park, W Sun, J W Miller, J M Seddon, L H Young, J F de Boer, T C Chen. "Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration" The British Journal of Ophthalmology 93(2): 176-181. (2008) en_US
dc.identifier.issn 1468-2079 en_US
dc.identifier.uri http://hdl.handle.net/2144/3356
dc.description.abstract BACKGROUND/AIMS:. To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomical changes in eyes with non-neovascular age-related macular degeneration (AMD) compared with time domain optical coherence tomography (TDOCT). METHODS:. Images were obtained from three eyes of three patients with AMD using an experimental SDOCT system. Both a titanium–sapphire (Ti:sapphire) laser and a superluminescent diode (SLD) were used as a broadband light source to achieve cross-sectional images of the retina. A qualitative and quantitative analysis was performed for structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyse drusen area and volume from SDOCT images. TDOCT was performed using the fast macular scan (StratusOCT, Carl Zeiss Meditec, Dublin, California). RESULTS:. SDOCT images can demonstrate structural changes associated with non-neovascular AMD. A new SDOCT algorithm can determine drusen area, drusen volume and proportion of drusen. CONCLUSIONS:. With new algorithms to determine drusen area and volume and its unprecedented simultaneous ultra-high speed ultra-high resolution imaging, SDOCT can improve the evaluation of structural abnormalities in non-neovascular AMD. en_US
dc.description.sponsorship National Institutes of Health (RO1EY014975, RO1-RR19768); Nidek en_US
dc.language.iso en en_US
dc.publisher BMJ Publishing Group en_US
dc.rights Copyright Yi et al 2009 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0/ en_US
dc.title Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age-Related Macular Degeneration en_US
dc.type article en_US
dc.identifier.doi 10.1136/bjo.2008.137356 en_US
dc.identifier.pubmedid 18697811 en_US
dc.identifier.pmcid 2628537 en_US


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Copyright Yi et al 2009 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright Yi et al 2009 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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