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Characteristics of the Early Immune Response Following Transplantation of Mouse ES Cell Derived Insulin-Producing Cell Clusters

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dc.contributor.author Boyd, Ashleigh S. en_US
dc.contributor.author Wood, Kathryn J. en_US
dc.date.accessioned 2012-01-12T17:35:46Z
dc.date.available 2012-01-12T17:35:46Z
dc.date.issued 2010-6-4 en_US
dc.identifier.citation Boyd, Ashleigh S., Kathryn J. Wood. "Characteristics of the Early Immune Response Following Transplantation of Mouse ES Cell Derived Insulin-Producing Cell Clusters" PLoS ONE 5(6): e10965. (2010) en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/2144/3405
dc.description.abstract BACKGROUND. The fully differentiated progeny of ES cells (ESC) may eventually be used for cell replacement therapy (CRT). However, elements of the innate immune system may contribute to damage or destruction of these tissues when transplanted. METHODOLOGY/PRINCIPAL FINDINGS. Herein, we assessed the hitherto ill-defined contribution of the early innate immune response in CRT after transplantation of either ESC derived insulin producing cell clusters (IPCCs) or adult pancreatic islets. Ingress of neutrophil or macrophage cells was noted immediately at the site of IPCC transplantation, but this infiltration was attenuated by day three. Gene profiling identified specific inflammatory cytokines and chemokines that were either absent or sharply reduced by three days after IPCC transplantation. Thus, IPCC transplantation provoked less of an early immune response than pancreatic islet transplantation. CONCLUSIONS/SIGNIFICANCE. Our study offers insights into the characteristics of the immune response of an ESC derived tissue in the incipient stages following transplantation and suggests potential strategies to inhibit cell damage to ensure their long-term perpetuation and functionality in CRT. en_US
dc.description.sponsorship Medical Research Council; BD Preanalytical Systems Europe; National Institutes of Health (P20RR018757); Roger Williams Medical Center; Wellcome Trust; European Union through the Optistem Network; Royal Society (Wolfson Research Merit Award) en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights Boyd, Wood. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_US
dc.title Characteristics of the Early Immune Response Following Transplantation of Mouse ES Cell Derived Insulin-Producing Cell Clusters en_US
dc.type article en_US
dc.identifier.doi 10.1371/journal.pone.0010965 en_US
dc.identifier.pubmedid 20532031 en_US
dc.identifier.pmcid 2881030 en_US


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