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Longitudinal Assessment of Cyst-Like Lesions of the Knee and Their Relation to Radiographic Osteoarthritis and MRI-Detected Effusion and Synovitis in Patients with Knee Pain

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dc.contributor.author Hayashi, Daichi en_US
dc.contributor.author Roemer, Frank W en_US
dc.contributor.author Dhina, Zineb en_US
dc.contributor.author Kwoh, C Kent en_US
dc.contributor.author Hannon, Michael J en_US
dc.contributor.author Moore, Carolyn en_US
dc.contributor.author Guermazi, Ali en_US
dc.date.accessioned 2012-01-12T17:38:57Z
dc.date.available 2012-01-12T17:38:57Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-9-15 en_US
dc.identifier.citation Hayashi, Daichi, Frank W Roemer, Zineb Dhina, C Kent Kwoh, Michael J Hannon, Carolyn Moore, Ali Guermazi. "Longitudinal assessment of cyst-like lesions of the knee and their relation to radiographic osteoarthritis and MRI-detected effusion and synovitis in patients with knee pain" Arthritis Research & Therapy 12(5):R172. (2010) en_US
dc.identifier.issn 1478-6362 en_US
dc.identifier.uri http://hdl.handle.net/2144/3414
dc.description.abstract INTRODUCTION. The purpose of the present study was to determine the prevalence of cystic lesions and cyst-like bursitides in subjects with frequent knee pain and to assess their relation to radiographic osteoarthritis (OA) severity; to describe bilaterality and size fluctuation of the lesions over 6 months; and to assess relations between the prevalence of synovium-lined lesions communicating with the joint capsule and severity of magnetic resonance imaging (MRI)-detected effusion and synovitis. METHODS. One hundred and sixty-three subjects (total 319 knees) aged 35 to 65 with chronic, frequent knee pain were included. Imaging with 3 Tesla MRI was performed at baseline and 6-month follow-up with the same protocols as those used in the Osteoarthritis Initiative. Severity of radiographic OA was assessed using the Kellgren-Lawrence grade (0 to 4). Severity of effusion and synovitis was graded 0 to 3 based on the Whole Organ Magnetic Resonance Imaging Score system. The associations of cysts and cyst-like bursitides and severity of radiographic OA, MRI-detected effusion and synovitis were analyzed using logistic regression controlling for clustering by person. The Wilcoxon signed-rank test was used to determine whether there was a significant change in the size of lesions between baseline and follow-up. RESULTS. At least one lesion (any type) was present in 222 (70%) knees. The most prevalent lesions were popliteal cysts (40%, 128/319), followed by subgastrocnemius bursitis (15%, 49/319) and proximal tibiofibular joint cysts (8%, 26/319). Bilateral lesions were seen in 49% of the subjects. Only popliteal cysts and subgastrocnemius bursitis showed a significant change in size (P < 0.001). No trend was observed between prevalence of any of the cyst-like lesions analyzed and the increasing radiographic OA severity. Increasing prevalence of subgastrocnemius bursitis was associated with increasing severity of effusion (P = 0.0072) and synovitis (P = 0.0033). CONCLUSIONS. None of the cyst-like lesions analyzed seems to be a marker of radiographic OA severity in knees with chronic frequent pain. Subgastrocnemius bursitis may be used as a marker of effusion/synovitis severity. Bilateral cyst-like lesions are relatively commonly observed in people with chronic knee pain. en_US
dc.description.sponsorship The Beverage Institute en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2010 Hayashi et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Longitudinal Assessment of Cyst-Like Lesions of the Knee and Their Relation to Radiographic Osteoarthritis and MRI-Detected Effusion and Synovitis in Patients with Knee Pain en_US
dc.type article en_US
dc.identifier.doi 10.1186/ar3132 en_US
dc.identifier.pubmedid 20843319 en_US
dc.identifier.pmcid 2990999 en_US


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Copyright 2010 Hayashi et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright 2010 Hayashi et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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