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Constraining Ribosomal RNA Conformational Space

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dc.contributor.author Favaretto, Paola en_US
dc.contributor.author Bhutkar, Arjun en_US
dc.contributor.author Smith, Temple F. en_US
dc.date.accessioned 2012-01-12T17:46:42Z
dc.date.available 2012-01-12T17:46:42Z
dc.date.issued 2005-09-09 en_US
dc.identifier.citation Favaretto, Paola, Arjun Bhutkar, Temple F. Smith. "Constraining ribosomal RNA conformational space" Nucleic Acids Research 33(16): 5106-5111. (2005) en_US
dc.identifier.issn 1362-4962 en_US
dc.identifier.uri http://hdl.handle.net/2144/3441
dc.description.abstract Despite the potential for many possible secondary-structure conformations, the native sequence of ribosomal RNA (rRNA) is able to find the correct and universally conserved core fold. This study reports a computational analysis investigating two mechanisms that appear to constrain rRNA secondary-structure conformational space: ribosomal proteins and rRNA sequence composition. The analysis was carried out by using rRNA–ribosomal protein interaction data for the Escherichia coli 16S rRNA and free energy minimization software for secondary-structure prediction. The results indicate that selection pressures on rRNA sequence composition and ribosomal protein–rRNA interaction play a key role in constraining the rRNA secondary structure to a single stable form. en_US
dc.description.sponsorship National Science Foundation (DBI-0205512); Boston University en_US
dc.language.iso en en_US
dc.publisher Oxford University Press en_US
dc.title Constraining Ribosomal RNA Conformational Space en_US
dc.type article en_US
dc.identifier.doi 10.1093/nar/gki805 en_US
dc.identifier.pubmedid 16155182 en_US
dc.identifier.pmcid 1214544 en_US


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