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Browsing School of Medicine by Title

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Browsing School of Medicine by Title

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  • Ren, Cizao; Vokonas, Pantel S; Suh, Helen; Fang, Shona; Christiani, David C; Schwartz, Joel (BioMed Central, 2010-12-7)
    BACKGROUND: Air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, ...
  • Lam, Jennifer S.; Huang, Haibin; Levitz, Stuart M. (Public Library of Science, 2007-10-10)
    BACKGROUND. An experimental approach for improving vaccine efficacy involves targeting antigens to mannose receptors (MRs) on dendritic cells (DCs) and other professional antigen presenting cells. Previously, we demonstrated ...
  • Krezanoski, Paul J; Comfort, Alison B; Hamer, Davidson H (BioMed Central, 2010-6-27)
    BACKGROUND Insecticide-treated bed nets (ITNs) have been shown to reduce morbidity and mortality due to malaria in sub-Saharan Africa. Strategies using incentives to increase ITN use could be more efficient than traditional ...
  • Novak, Peter; Novak, Vera (BioMed Central, 2006-5-4)
    BACKGROUND Previous studies have suggested that impaired proprioceptive processing in the striatum may contribute to abnormal gait in Parkinson's disease (PD). METHODS This pilot study assessed the effects of enhanced ...
  • Park, Sung Kyun; O'Neill, Marie S.; Vokonas, Pantel S.; Sparrow, David; Schwartz, Joel (National Institue of Environmental Health Sciences, 2005-03)
    Reduced heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with air pollution, especially fine particulate matter [< 2.5 μm in aerodynamic diameter (PM2.5)]. We examined the ...
  • Peters, Alan (Frontiers Research FoundationFrontiers Research Foundation, 2009-07-06)
    The effects of aging on myelinated nerve fibers of the central nervous system are complex. Many myelinated nerve fibers in white matter degenerate and are lost, leading to some disconnections between various parts of the ...
  • Zurovac, D; Njogu, J; Akhwale, W; Hamer, D H; Larson, B A; Snow, R W (Blackwell Publishing Ltd, 2008-06)
    OBJECTIVE. The recent change of treatment policy for uncomplicated malaria from sulfadoxine-pyrime-thamine to artemether-lumefantrine (AL) in Kenya was accompanied by revised malaria diagnosis recommendations promoting ...
  • Kim, Noel N; Stankovic, Miljan; Armagan, Abdullah; Cushman, Tulay T; Goldstein, Irwin; Traish, Abdulmaged M (BioMed Central, 2006-9-13)
    BACKGROUND. Tamoxifen, a selective estrogen receptor modulator with both estrogenic and anti-estrogenic activity, is widely used as adjuvant therapy in breast cancer patients. Treatment with tamoxifen is associated with ...
  • Wilcox, Marsha A; Wyszynski, Diego F; Panhuysen, Carolien I; Ma, Qianli; Yip, Agustin; Farrell, John; Farrer, Lindsay A (BioMed Central, 2003-12-31)
    BACKGROUND. The Framingham Heart Study has contributed a great deal to advances in medicine. Most of the phenotypes investigated have been univariate traits (quantitative or qualitative). The aims of this study are to ...
  • Walter, R; Gottlieb, D J; O'Connor, G T (National Institute of Environmental Health Sciences, 2000-08)
    Current understanding of the pathogenesis of chronic obstructive pulmonary disease (COPD), a source of substantial morbidity and mortality in the United States, suggests that chronic inflammation leads to the airways ...
  • D'Armiento, Jeanine M; Scharf, Steven M; Roth, Michael D; Connett, John E; Ghio, Andrew; Sternberg, David; Goldin, Jonathan G; Louis, Thomas A; Mao, Jenny T; O'Connor, George T; Ramsdell, Joe W; Ries, Andrew L; Schluger, Neil W; Sciurba, Frank C; Skeans, Melissa A; Voelker, Helen; Walter, Robert E; Wendt, Christine H; Weinmann, Gail G; Wise, Robert A; Foronjy, Robert F (BioMed Central, 2009-11-19)
    BACKGROUND. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that ...
  • Borzecki, A M; Kader, B; Berlowitz, D R (Nature Publishing Group, 2009-05-14)
    Hypertension guidelines stress that patients with severe hypertension (systolic blood pressure (BP)⩾180 or diastolic BP⩾110mmHg) require multiple drugs to achieve control and should have close follow-up to prevent adverse ...
  • Mastroeni, Diego; McKee, Ann; Grover, Andrew; Rogers, Joseph; Coleman, Paul D. (Public Library of Science, 2009-8-12)
    DNA methylation [1], [2] is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease ...
  • Kim, Theresa W; Kertesz, Stefan G; Horton, Nicholas J; Tibbetts, Nicole; Samet, Jeffrey H (BioMed Central, 2006-2-27)
    BACKGROUND: Because individuals with HIV/AIDS often have complex medical and social needs, the impact of housing status on medical service utilization is difficult to isolate from the impact of conditions that may worsen ...
  • Di Stefano, Bruno; Buecker, Christa; Ungaro, Federica; Prigione, Alessandro; Chen, Hsu-Hsin; Welling, Maaike; Eijpe, Maureen; Mostoslavsky, Gustavo; Tesar, Paul; Adjaye, James; Geijsen, Niels; Broccoli, Vania (Public Library of Science, 2010-12-30)
    Recent data demonstrates that stem cells can exist in two morphologically, molecularly and functionally distinct pluripotent states; a naïve LIF-dependent pluripotent state which is represented by murine embryonic stem ...
  • Budtz-Jørgensen, Esben; Keiding, Niels; Grandjean, Philippe; Weihe, Pal (BioMed Central, 2002-10-14)
    BACKGROUND: Observational studies in epidemiology always involve concerns regarding validity, especially measurement error, confounding, missing data, and other problems that may affect the study outcomes. Widely used ...
  • Latourelle, Jeanne C; Dybdahl, Merete; Destefano, Anita L; Myers, Richard H; Lash, Timothy L (Dove Medical Press, 2010-8-9)
    PURPOSE: Estrogen exposure has been associated with the occurrence of Parkinson's disease (PD), as well as many other disorders, and yet the mechanisms underlying these relations are often unknown. While it is likely that ...
  • Elliott, Katherine S.; Zeggini, Eleftheria; McCarthy, Mark I.; Gudmundsson, Julius; Sulem, Patrick; Stacey, Simon N.; Thorlacius, Steinunn; Amundadottir, Laufey; Grönberg, Henrik; Xu, Jianfeng; Gaborieau, Valerie; Eeles, Rosalind A.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Muir, Kenneth; Hwang, Shih-Jen; Spitz, Margaret R.; Zanke, Brent; Carvajal-Carmona, Luis; Brown, Kevin M.; Mann, Graham J.; Hayward, Nicholas K.; Macgregor, Stuart; Tomlinson, Ian P. M.; Lemire, Mathieu; Amos, Christopher I.; Murabito, Joanne M.; Isaacs, William B.; Easton, Douglas F.; Brennan, Paul; Barkardottir, Rosa B.; Gudbjartsson, Daniel F.; Rafnar, Thorunn; Hunter, David J.; Chanock, Stephen J.; Stefansson, Kari; Ioannidis, John P. A.; Hopper, John L.; Aitken, Joanne F.; Kefford, Richard F.; Giles, Graham G.; Armstrong, Bruce K. (Public Library of Science, 2010-5-28)
    BACKGROUND. Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may ...
  • Goetz, Matthew Bidwell; Hoang, Tuyen; Henry, S. Randal; Knapp, Herschel; Anaya, Henry D.; Gifford, Allen L.; Asch, Steven M. (Springer-Verlag, 2009-10-2)
    BACKGROUND Sustainability—the routinization and institutionalization of processes that improve the quality of healthcare—is difficult to achieve and not often studied. OBJECTIVE To evaluate the sustainability of increased ...
  • Chatterjee, Anirban; Ghosh, Sudip K.; Jang, Ken; Bullitt, Esther; Moore, Landon; Robbins, Phillips W.; Samuelson, John (Public Library of Science, 2009-7-3)
    The cyst wall of Entamoeba invadens (Ei), a model for the human pathogen Entamoeba histolytica, is composed of fibrils of chitin and three chitin-binding lectins called Jacob, Jessie3, and chitinase. Here we show chitin, ...

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