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Browsing Basic Science by Title

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  • Estevez, Maureen E.; Kolesnikov, Alexander V.; Ala-Laurila, Petri; Crouch, Rosalie K.; Govardovskii, Victor I.; Cornwall, M. Carter (The Rockefeller University Press, 2009-07-27)
    Cone photoreceptors of the vertebrate retina terminate their response to light much faster than rod photoreceptors. However, the molecular mechanisms underlying this rapid response termination in cones are poorly understood. ...
  • Ferguson, Andrew R; Corley, Ronald B (BioMed Central, 2005-4-18)
    BACKGROUND: Marginal zone (MZ) B cells play important roles in the early phases of humoral immune responses. In addition to possessing an inherent capacity to rapidly differentiate into antibody secreting cells, MZ B cells ...
  • Blum, Kenneth; Chen, Amanda Lih Chuan; Chen, Thomas JH; Braverman, Eric R; Reinking, Jeffrey; Blum, Seth H; Cassel, Kimberly; Downs, Bernard W; Waite, Roger L; Williams, Lonna; Prihoda, Thomas J; Kerner, Mallory M; Palomo, Tomas; Comings, David E; Tung, Howard; Rhoades, Patrick; Oscar-Berman, Marlene (BioMed Central, 2008-11-12)
    BACKGROUND AND HYPOTHESIS. Based on neurochemical and genetic evidence, we suggest that both prevention and treatment of multiple addictions, such as dependence to alcohol, nicotine and glucose, should involve a biphasic ...
  • Genzen, Jonathan R; Yang, Dan; Ravid, Katya; Bordey, Angelique (BioMed Central, 2009-11-18)
    BACKGROUND: Ependymal cells form a protective monolayer between the brain parenchyma and cerebrospinal fluid (CSF). They possess motile cilia important for directing the flow of CSF through the ventricular system. While ...
  • Yamin, Rina; Zhao, Cheng; O'Connor, Peter B; McKee, Ann C; Abraham, Carmela R (BioMed Central, 2009-7-23)
    BACKGROUND The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain ...
  • McKinley, Laura; Kim, Jiyoun; Bolgos, Gerald L; Siddiqui, Javed; Remick, Daniel G (BioMed Central, 2006-10-17)
    BACKGROUND. Previous genetic analysis has shown that a deletion in the complement component 5 gene-coding region renders mice more susceptible to allergen-induced airway hyperresponsiveness (AHR) due to reduced IL-12 ...
  • Millien, Guetchyn; Spira, Avrum; Hinds, Anne; Wang, Junling; Williams, Mary C; Ramirez, Maria I (BioMed Central, 2006-7-25)
    BACKGROUND. Development of lung alveolar sacs of normal structure and size at late gestation is necessary for the gas exchange process that sustains respiration at birth. Mice lacking the lung differentiation gene T1α ...
  • Soscia, Stephanie J.; Kirby, James E.; Washicosky, Kevin J.; Tucker, Stephanie M.; Ingelsson, Martin; Hyman, Bradley; Burton, Mark A.; Goldstein, Lee E.; Duong, Scott; Tanzi, Rudolph E.; Moir, Robert D. (Public Library of Science, 2010-3-3)
    BACKGROUND. The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. ...
  • Tao, Rong; Gong, Jun; Luo, Xixi; Zang, Mengwei; Guo, Wen; Wen, Rong; Luo, Zhijun (BioMed Central, 2010-2-18)
    BACKGROUND AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme that is activated when cells experience energy deficiency and conversely suppressed in surfeit of energy supply. AMPK activation improves insulin ...
  • Blum, Kenneth; Chen, Amanda Lih-Chuan; Braverman, Eric R; Comings, David E; Chen, Thomas JH; Arcuri, Vanessa; Blum, Seth H; Downs, Bernard W; Waite, Roger L; Notaro, Alison; Lubar, Joel; Williams, Lonna; Prihoda, Thomas J; Palomo, Tomas; Oscar-Berman, Marlene (Dove Medical Press, 2008)
    Molecular genetic studies have identified several genes that may mediate susceptibility to attention deficit hyperactivity disorder (ADHD). A consensus of the literature suggests that when there is a dysfunction in the ...
  • Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Greve, Douglas N.; Salat, David H.; Buckner, Randy L.; Fischl, Bruce (Oxford University Press, 2009-5-21)
    Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...
  • Lun, Desmond S; Sherrid, Ashley; Weiner, Brian; Sherman, David R; Galagan, James E (BioMed Central, 2009-12-22)
    CSdeconv is a novel method for determining the location of transcription factor binding from ChIP-seq data that discriminates closely-spaced sites. We present CSDeconv, a computational method that determines locations of ...
  • Davis, David A.; Wilson, Meredith H.; Giraud, Jodel; Xie, Zhigang; Tseng, Huang-Chun; England, Cheryl; Herscovitz, Haya; Tsai, Li-Huei; Delalle, Ivana (Public Library of Science, 2009-10-6)
    An actin regulatory protein unexpectedly also controls microtubule polymerization during the formation and maintenance of cellular outgrowths in neurons. Capping protein (CP) is a heterodimer that regulates actin assembly ...
  • Larson, Pamela S; Schlechter, Benjamin L; King, Chia-Lin; Yang, Qiong; Glass, Chelsea N; Mack, Charline; Pistey, Robert; de las Morenas, Antonio; Rosenberg, Carol L (BioMed Central, 2008-3-6)
    BACKGROUND. CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast ...
  • Ma, Qiangzhong; Wang, Yawen; Lo, Agnes Shuk-Yee; Gomes, Erica M.; Junghans, Richard P. (Hindawi Publishing Corporation, 2010-6-30)
    The successful ex vivo expansion of a large numbers of T cells is a prerequisite for adoptive immunotherapy. In this study, we found that cell density had important effects on the process of expansion of T cells in vitro. ...
  • Shang, Eva H.; Zhdanova, Irina V. (Public Library of Science, 2007-7-11)
    BACKGROUND. Prenatal exposure to cocaine can be deleterious to embryonic brain development, but the results in humans remain controversial, the mechanisms involved are not well understood and effective therapies are yet ...
  • Wu, Yuntao; Yoder, Alyson; Yu, Dongyang; Wang, Weifeng; Liu, Juan; Barrett, Tracey; Wheeler, David; Schlauch, Karen (BioMed Central, 2008-10-17)
    Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. ...
  • Yu, Lili; Tucci, Valter; Kishi, Shuji; Zhdanova, Irina V. (Public Library of Science, 2006-12-20)
    BACKGROUND. Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and ...
  • Allen, Laura B.; White, Kamila S.; Barlow, David H.; Shear, M. Katherine; Gorman, Jack M.; Woods, Scott W. (Springer US, 2009-7-24)
    Research evaluating the relationship of comorbidity to treatment outcome for panic disorder has produced mixed results. The current study examined the relationship of comorbid depression and anxiety to treatment outcome ...
  • Roberts, Richard J.; Chang, Yi-Chien; Hu, Zhenjun; Rachlin, John N.; Anton, Brian P.; Pokrzywa, Revonda M.; Choi, Han-Pil; Faller, Lina L.; Guleria, Jyotsna; Housman, Genevieve; Klitgord, Niels; Mazumdar, Varun; McGettrick, Mark G.; Osmani, Lais; Swaminathan, Rajeswari; Tao, Kevin R.; Letovsky, Stan; Vitkup, Dennis; Segrè, Daniel; Salzberg, Steven L.; Delisi, Charles; Steffen, Martin; Kasif, Simon (2010-11-20)
    COMBREX (http://combrex.bu.edu) is a project to increase the speed of the functional annotation of new bacterial and archaeal genomes. It consists of a database of functional predictions produced by computational biologists ...

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