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Browsing Basic Science by Title

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Browsing Basic Science by Title

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  • Carey, Robyn M; Balcz, Brigitte A; Lopez-Coviella, Ignacio; Slack, Barbara E (BioMed Central, 2005-8-11)
    BACKGROUND. The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by α-secretase, or internalized within clathrin-coated vesicles. ...
  • Ilyinskii, Petr O.; Gambaryan, Alexandra S.; Meriin, Anatoli B.; Gabai, Vladimir; Kartashov, Alex; Thoidis, Galini; Shneider, Alexander M. (Public Library of Science, 2008-1-16)
    The effectiveness of recombinant vaccines encoding full-length M2 protein of influenza virus or its ectodomain (M2e) have previously been tested in a number of models with varying degrees of success. Recently, we reported ...
  • Chao, Lily C.; Wroblewski, Kevin; Zhang, Zidong; Pei, Liming; Vergnes, Laurent; Ilkayeva, Olga R.; Ding, Shi Ying; Reue, Karen; Watt, Matthew J.; Newgard, Christopher B.; Pilch, Paul F.; Hevener, Andrea L.; Tontonoz, Peter (American Diabetes Association, 2009-9-9)
    OBJECTIVE: Nur77 is an orphan nuclear receptor with pleotropic functions. Previous studies have identified Nur77 as a transcriptional regulator of glucose utilization genes in skeletal muscle and gluconeogenesis in liver. ...
  • Jiang, Xiaoyu; Nariai, Naoki; Steffen, Martin; Kasif, Simon; Kolaczyk, Eric D (BioMed Central, 2008-8-22)
    BACKGROUND. In the current climate of high-throughput computational biology, the inference of a protein's function from related measurements, such as protein-protein interaction relations, has become a canonical task. Most ...
  • Colijn, Caroline; Brandes, Aaron; Zucker, Jeremy; Lun, Desmond S.; Weiner, Brian; Farhat, Maha R.; Cheng, Tan-Yun; Moody, D. Branch; Murray, Megan; Galagan, James E. (Public Library of Science, 2009-8-28)
    Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its importance, the ability to study metabolism at a global scale using genomic technologies is limited. ...
  • Meyer, Rosana D.; Sacks, David B.; Rahimi, Nader (Public Library of Science, 2008-12-3)
    BACKGROUND. Vascular endothelial growth factor receptor-2 (VEGFR-2) signaling is an obligate requirement for normal development and pathological angiogenesis such as cancer and age-related macular degeneration. Although ...
  • Bowirrat, Abdalla; Cui, Jing; Waraska, Kristin; Friedland, Robert P; Oscar-Berman, Marlene; Farrer, Lindsay A; Korczyn, Amos; Baldwin, Clinton T (Dove Medical Press, 2005)
    The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer's disease (AD). This study investigated whether the ACE gene ...
  • Near, Richard I.; Smith, Richard S.; Toselli, Paul A.; Freddo, Thomas F.; Bloom, Alexander B.; Vanden Borre, Pierre; Seldin, David C.; Lerner, Adam (Molecular Vision, 2009-4-03)
    PURPOSE. AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor ...
  • Valmas, Charalampos; Grosch, Melanie N.; Schümann, Michael; Olejnik, Judith; Martinez, Osvaldo; Best, Sonja M.; Krähling, Verena; Basler, Christopher F.; Mühlberger, Elke (Public Library of Science, 2010-1-15)
    Previous studies have demonstrated that Marburg viruses (MARV) and Ebola viruses (EBOV) inhibit interferon (IFN)-α/β signaling but utilize different mechanisms. EBOV inhibits IFN signaling via its VP24 protein which blocks ...
  • Ricupero, D.; Taylor, L.; Tlucko, A.; Navarro, J.; Polgar, P. (Hindawi Publishing Corporation, 1982)
    Regulatory mechanisms in bradykinin (BK) activated release of arachidonate (ARA) and synthesis of prostaglandin (PG) and platelet activating factor (PAF) were studied in bovine pulmonary artery endothelial cells (BPAEC). ...
  • Miyagishima, Kiyoharu J.; Cornwall, M. Carter; Sampath, Alapakkam P. (The Rockefeller University Press, 2009-08-17)
    The shutoff of active intermediates in the phototransduction cascade and the reconstitution of the visual pigment play key roles in the recovery of sensitivity after the exposure to bright light in both rod and cone ...
  • Liou, Louis S; Shi, Ting; Duan, Zhong-Hui; Sadhukhan, Provash; Der, Sandy D; Novick, Andrew A; Hissong, John; Skacel, Marek; Almasan, Alexandru; DiDonato, Joseph A (BioMed Central, 2004-6-22)
    BACKGROUND. Renal cell carcinoma (RCC) is the most common cancer in adult kidney. The accuracy of current diagnosis and prognosis of the disease and the effectiveness of the treatment for the disease are limited by the ...
  • Ress, David; Thompson, Jeffrey K.; Rokers, Bas; Khan, Reswanul K.; Huk, Alexander C. (Frontiers Research Foundation, 2009-06-29)
    Popular hemodynamic brain imaging methods, such as blood oxygen-level dependent functional magnetic resonance imaging (BOLD fMRI), would benefit from a detailed understanding of the mechanisms by which oxygen is delivered ...
  • Kao, Patricia F.; Davis, David A.; Banigan, Meredith G.; Vanderburg, Charles R.; Seshadri, Sudha; Delalle, Ivana (Public Library of Science, 2010-10-13)
    During the progression of Alzheimer's disease (AD), hippocampal neurons undergo cytoskeletal reorganization, resulting in degenerative as well as regenerative changes. As neurofibrillary tangles form and dystrophic neurites ...
  • Brown, Jeffrey W.; McKnight, C. James (Public Library of Science, 2010-2-24)
    BACKGROUND. Brush border microvilli are ~1-µm long finger-like projections emanating from the apical surfaces of certain, specialized absorptive epithelial cells. A highly symmetric hexagonal array of thousands of these ...
  • Ahmad, Q Rushdy; Nguyen, Dat H; Wingerd, Mark A; Church, George M; Steffen, Martin A (BioMed Central, 2005-6-8)
    BACKGROUND. The observed molecular weight of a protein on a 1D polyacrylamide gel can provide meaningful insight into its biological function. Differences between a protein's observed molecular weight and that predicted ...
  • Bowirrat, Abdalla; Reider-Groswasser, Irith I; Oscar-Berman, Marlene; Aizenstein, Orna; Levy, Gad; Korczyn, Amos D (Dove Medical Press, 2005)
    Magnetic resonance imaging (MRI) findings are reported from 15 individuals in an Arab–Israeli community who were diagnosed with Alzheimer's disease (AD). The quantitative parameters that were used for MRI analyses included ...
  • Bastiani, Michele; Liu, Libin; Hill, Michelle M.; Jedrychowski, Mark P.; Nixon, Susan J.; Lo, Harriet P.; Abankwa, Daniel; Luetterforst, Robert; Fernandez-Rojo, Manuel; Breen, Michael R.; Gygi, Steven P.; Vinten, Jorgen; Walser, Piers J.; North, Kathryn N.; Hancock, John F.; Pilch, Paul F.; Parton, Robert G. (The Rockefeller University Press, 2009-06-22)
    Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now ...
  • Moradkhani, Kamran; Préhu, Claude; Old, John; Henderson, Shirley; Balamitsa, Vera; Luo, Hong-Yuan; Poon, Man-Chiu; Chui, David H. K.; Wajcman, Henri; Patrinos, George P. (Springer-Verlag, 2008-10-16)
    The human α-globin genes are paralogues, sharing a high degree of DNA sequence similarity and producing an identical α-globin chain. Over half of the α-globin structural variants reported to date are only characterized at ...
  • Yip, Agustín G; Green, Robert C; Huyck, Matthew; Cupples, L Adrienne; Farrer, Lindsay A (BioMed Central, 2005-1-12)
    BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) use may protect against Alzheimer's disease (AD) risk. We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-ε4 ...

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