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Browsing Basic Science by Title

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  • Soscia, Stephanie J.; Kirby, James E.; Washicosky, Kevin J.; Tucker, Stephanie M.; Ingelsson, Martin; Hyman, Bradley; Burton, Mark A.; Goldstein, Lee E.; Duong, Scott; Tanzi, Rudolph E.; Moir, Robert D. (Public Library of Science, 2010-3-3)
    BACKGROUND. The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. ...
  • Tao, Rong; Gong, Jun; Luo, Xixi; Zang, Mengwei; Guo, Wen; Wen, Rong; Luo, Zhijun (BioMed Central, 2010-2-18)
    BACKGROUND AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme that is activated when cells experience energy deficiency and conversely suppressed in surfeit of energy supply. AMPK activation improves insulin ...
  • Blum, Kenneth; Chen, Amanda Lih-Chuan; Braverman, Eric R; Comings, David E; Chen, Thomas JH; Arcuri, Vanessa; Blum, Seth H; Downs, Bernard W; Waite, Roger L; Notaro, Alison; Lubar, Joel; Williams, Lonna; Prihoda, Thomas J; Palomo, Tomas; Oscar-Berman, Marlene (Dove Medical Press, 2008)
    Molecular genetic studies have identified several genes that may mediate susceptibility to attention deficit hyperactivity disorder (ADHD). A consensus of the literature suggests that when there is a dysfunction in the ...
  • Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Greve, Douglas N.; Salat, David H.; Buckner, Randy L.; Fischl, Bruce (Oxford University Press, 2009-5-21)
    Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...
  • Lun, Desmond S; Sherrid, Ashley; Weiner, Brian; Sherman, David R; Galagan, James E (BioMed Central, 2009-12-22)
    CSdeconv is a novel method for determining the location of transcription factor binding from ChIP-seq data that discriminates closely-spaced sites. We present CSDeconv, a computational method that determines locations of ...
  • Davis, David A.; Wilson, Meredith H.; Giraud, Jodel; Xie, Zhigang; Tseng, Huang-Chun; England, Cheryl; Herscovitz, Haya; Tsai, Li-Huei; Delalle, Ivana (Public Library of Science, 2009-10-6)
    An actin regulatory protein unexpectedly also controls microtubule polymerization during the formation and maintenance of cellular outgrowths in neurons. Capping protein (CP) is a heterodimer that regulates actin assembly ...
  • Larson, Pamela S; Schlechter, Benjamin L; King, Chia-Lin; Yang, Qiong; Glass, Chelsea N; Mack, Charline; Pistey, Robert; de las Morenas, Antonio; Rosenberg, Carol L (BioMed Central, 2008-3-6)
    BACKGROUND. CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast ...
  • Ma, Qiangzhong; Wang, Yawen; Lo, Agnes Shuk-Yee; Gomes, Erica M.; Junghans, Richard P. (Hindawi Publishing Corporation, 2010-6-30)
    The successful ex vivo expansion of a large numbers of T cells is a prerequisite for adoptive immunotherapy. In this study, we found that cell density had important effects on the process of expansion of T cells in vitro. ...
  • Shang, Eva H.; Zhdanova, Irina V. (Public Library of Science, 2007-7-11)
    BACKGROUND. Prenatal exposure to cocaine can be deleterious to embryonic brain development, but the results in humans remain controversial, the mechanisms involved are not well understood and effective therapies are yet ...
  • Wu, Yuntao; Yoder, Alyson; Yu, Dongyang; Wang, Weifeng; Liu, Juan; Barrett, Tracey; Wheeler, David; Schlauch, Karen (BioMed Central, 2008-10-17)
    Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. ...
  • Yu, Lili; Tucci, Valter; Kishi, Shuji; Zhdanova, Irina V. (Public Library of Science, 2006-12-20)
    BACKGROUND. Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and ...
  • Allen, Laura B.; White, Kamila S.; Barlow, David H.; Shear, M. Katherine; Gorman, Jack M.; Woods, Scott W. (Springer US, 2009-7-24)
    Research evaluating the relationship of comorbidity to treatment outcome for panic disorder has produced mixed results. The current study examined the relationship of comorbid depression and anxiety to treatment outcome ...
  • Roberts, Richard J.; Chang, Yi-Chien; Hu, Zhenjun; Rachlin, John N.; Anton, Brian P.; Pokrzywa, Revonda M.; Choi, Han-Pil; Faller, Lina L.; Guleria, Jyotsna; Housman, Genevieve; Klitgord, Niels; Mazumdar, Varun; McGettrick, Mark G.; Osmani, Lais; Swaminathan, Rajeswari; Tao, Kevin R.; Letovsky, Stan; Vitkup, Dennis; Segrè, Daniel; Salzberg, Steven L.; Delisi, Charles; Steffen, Martin; Kasif, Simon (2010-11-20)
    COMBREX (http://combrex.bu.edu) is a project to increase the speed of the functional annotation of new bacterial and archaeal genomes. It consists of a database of functional predictions produced by computational biologists ...
  • Champion, Mia D.; Zeng, Qiandong; Nix, Eli B.; Nano, Francis E.; Keim, Paul; Kodira, Chinnappa D.; Borowsky, Mark; Young, Sarah; Koehrsen, Michael; Engels, Reinhard; Pearson, Matthew; Howarth, Clint; Larson, Lisa; White, Jared; Alvarado, Lucia; Forsman, Mats; Bearden, Scott W.; Sjöstedt, Anders; Titball, Richard; Michell, Stephen L.; Birren, Bruce; Galagan, James (Public Library of Science Pathogens, 2009-5-29)
    Tularemia is a geographically widespread, severely debilitating, and occasionally lethal disease in humans. It is caused by infection by a gram-negative bacterium, Francisella tularensis. In order to better understand its ...
  • Steiling, Katrina; Kadar, Aran Y.; Bergerat, Agnes; Flanigon, James; Sridhar, Sriram; Shah, Vishal; Ahmad, Q. Rushdy; Brody, Jerome S.; Lenburg, Marc E.; Steffen, Martin; Spira, Avrum (Public Libary of Science, 2009-4-9)
    BACKGROUND. Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the lung and airway, the impact of smoking on the airway epithelial proteome and its relationship to smoking-related ...
  • Spencer, Jean L.; Bernanke, Joel A.; Buczek-Thomas, Jo Ann; Nugent, Matthew A. (Public Library of Science, 2010-2-23)
    BACKGROUND. Increasing evidence has revealed important roles for complex glycans as mediators of normal and pathological processes. Glycosaminoglycans are a class of glycans that bind and regulate the function of a wide ...
  • Frank, Christopher L.; Ge, Xuecai; Xie, Zhigang; Zhou, Ying; Tsai, Li-Huei (American Society for Biochemistry and Molecular Biology, 2010-8-19)
    Organogenesis is a highly integrated process with a fundamental requirement for precise cell cycle control. Mechanistically, the cell cycle is composed of transitions and thresholds that are controlled by coordinated ...
  • Dan, Jennifer M.; Wang, Jennifer P.; Lee, Chrono K.; Levitz, Stuart M. (Public Library of Science, 2008-4-30)
    While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC ...
  • Verger, Denis; Bullitt, Esther; Hultgren, Scott J; Waksman, Gabriel (Public Library of SciencePathogens, 2007-5-18)
    P pili are important adhesive fibres involved in kidney infection by uropathogenic Escherichia coli strains. P pili are assembled by the conserved chaperone-usher pathway, which involves the PapD chaperone and the PapC ...
  • Sipe, J. D.; Martel-Pelletier, J.; Otterness, I. G.; Pelletier, J.-P. (Hindawi Publishing Corporation, 1994)
    The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions ...

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