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Browsing School of Public Health by Title

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  • Chasman, Daniel I.; Paré, Guillaume; Mora, Samia; Hopewell, Jemma C.; Peloso, Gina; Clarke, Robert; Cupples, L. Adrienne; Hamsten, Anders; Kathiresan, Sekar; Mälarstig, Anders; Ordovas, José M.; Ripatti, Samuli; Parker, Alex N.; Miletich, Joseph P.; Ridker, Paul M. (Public Library of Science, 2009-11-20)
    While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based measurements more accurately reflect lipoprotein particle concentrations according to ...
  • Larson, Martin G; Atwood, Larry D; Benjamin, Emelia J; Cupples, L Adrienne; D'Agostino, Ralph B; Fox, Caroline S; Govindaraju, Diddahally R; Guo, Chao-Yu; Heard-Costa, Nancy L; Hwang, Shih-Jen; Murabito, Joanne M; Newton-Cheh, Christopher; O'Donnell, Christopher J; Seshadri, Sudha; Vasan, Ramachandran S; Wang, Thomas J; Wolf, Philip A; Levy, Daniel (BioMed Central, 2007-9-19)
    BACKGROUND: Cardiovascular disease (CVD) and its most common manifestations – including coronary heart disease (CHD), stroke, heart failure (HF), and atrial fibrillation (AF) – are major causes of morbidity and mortality. ...
  • Cupples, L Adrienne; Arruda, Heather; Benjamin, Emelia; D'Agostino, Ralph; Demissie, Serkalem; DeStefano, Anita; Dupuis, Josee; Falls, Kathleen; Fox, Caroline; Gottlieb, Daniel; et al. (2007)
    BACKGROUND:The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. ...
  • Cupples, L Adrienne; Arruda, Heather T; Benjamin, Emelia J; D'Agostino, Ralph B; Demissie, Serkalem; DeStefano, Anita L; Dupuis, Josée; Falls, Kathleen M; Fox, Caroline S; Gottlieb, Daniel J; Govindaraju, Diddahally R; Guo, Chao-Yu; Heard-Costa, Nancy L; Hwang, Shih-Jen; Kathiresan, Sekar; Kiel, Douglas P; Laramie, Jason M; Larson, Martin G; Levy, Daniel; Liu, Chun-Yu; Lunetta, Kathryn L; Mailman, Matthew D; Manning, Alisa K; Meigs, James B; Murabito, Joanne M; Newton-Cheh, Christopher; O'Connor, George T; O'Donnell, Christopher J; Pandey, Mona; Seshadri, Sudha; Vasan, Ramachandran S; Wang, Zhen Y; Wilk, Jemma B; Wolf, Philip A; Yang, Qiong; Atwood, Larry D (BioMed Central, 2007-9-19)
    BACKGROUND: The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected ...
  • Howard, Gregory J; Schlezinger, Jennifer J; Hahn, Mark E; Webster, Thomas F (National Institute of Environmental Health Sciences, 2010-05)
    BACKGROUND. Predicting the expected outcome of a combination exposure is critical to risk assessment. The toxic equivalency factor (TEF) approach used for analyzing joint effects of dioxin-like chemicals is a special case ...
  • Yang, Qiong; Chazaro, Irmarie; Cui, Jing; Guo, Chao-Yu; Demissie, Serkalem; Larson, Martin; Atwood, Larry D; Cupples, L Adrienne; DeStefano, Anita L (BioMed Central, 2003-12-31)
    BACKGROUND. We explored three approaches to heritability and linkage analyses of longitudinal total cholesterol levels (CHOL) in the Genetic Analysis Workshop 13 simulated data without knowing the answers. The first two ...
  • Bailey-Wilson, Joan E; Almasy, Laura; de Andrade, Mariza; Bailey, Julia; Bickeböller, Heike; Cordell, Heather J; Daw, E Warwick; Goldin, Lynn; Goode, Ellen L; Gray-McGuire, Courtney; Hening, Wayne; Jarvik, Gail; Maher, Brion S; Mendell, Nancy; Paterson, Andrew D; Rice, John; Satten, Glen; Suarez, Brian; Vieland, Veronica; Wilcox, Marsha; Zhang, Heping; Ziegler, Andreas; MacCluer, Jean W (BioMed Central, 2005-12-30)
  • Cordell, Heather J; de Andrade, Mariza; Babron, Marie-Claude; Bartlett, Christopher W; Beyene, Joseph; Bickeböller, Heike; Culverhouse, Robert; Cupples, L Adrienne; Daw, E Warwick; Dupuis, Josée; Falk, Catherine T; Ghosh, Saurabh; Goddard, Katrina A; Goode, Ellen L; Hauser, Elizabeth R; Martin, Lisa J; Martinez, Maria; North, Kari E; Saccone, Nancy L; Schmidt, Silke; Tapper, William; Thomas, Duncan; Tritchler, David; Vieland, Veronica J; Wijsman, Ellen M; Wilcox, Marsha A; Witte, John S; Yang, Qiong; Ziegler, Andreas; Almasy, Laura; MacCluer, Jean W (BioMed Central, 2007-12-18)
  • Cupples, L Adrienne; Beyene, Joseph; Bickeböller, Heike; Daw, E Warwick; Fallin, M Daniele; Gauderman, W James; Ghosh, Saurabh; Goode, Ellen L; Hauser, Elizabeth R; Hinrichs, Anthony; Kent, Jack W; Martin, Lisa J; Martinez, Maria; Neuman, Rosalind J; Province, Michael; Szymczak, Silke; Wilcox, Marsha A; Ziegler, Andreas; MacCluer, Jean W; Almasy, Laura (BioMed Central, 2009-12-15)
  • Poage, Graham M.; Christensen, Brock C.; Houseman, E. Andres; McClean, Michael D.; Wiencke, John K.; Posner, Marshall R.; Clark, John R.; Nelson, Heather H.; Marsit, Carmen J.; Kelsey, Karl T. (Public Library of Science, 2010-3-11)
    BACKGROUND. Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. Little work has been done that simultaneously ...
  • Seshadri, Sudha; DeStefano, Anita L; Au, Rhoda; Massaro, Joseph M; Beiser, Alexa S; Kelly-Hayes, Margaret; Kase, Carlos S; D'Agostino, Ralph B; DeCarli, Charles; Atwood, Larry D; Wolf, Philip A (BioMed Central, 2007-9-19)
    BACKGROUND: Brain magnetic resonance imaging (MRI) and cognitive tests can identify heritable endophenotypes associated with an increased risk of developing stroke, dementia and Alzheimer's disease (AD). We conducted a ...
  • Lunetta, Kathryn; D'Agostino, Ralph; Karasik, David; Benjamin, Emelia; Guo, Chao-Yu; Govindaraju, Raju; Kiel, Douglas; Kelly-Hayes, Margaret; Massaro, Joseph; Pencina, Michael; et al. (2007)
    BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS:We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for ...
  • Lunetta, Kathryn L; D'Agostino, Ralph B; Karasik, David; Benjamin, Emelia J; Guo, Chao-Yu; Govindaraju, Raju; Kiel, Douglas P; Kelly-Hayes, Margaret; Massaro, Joseph M; Pencina, Michael J; Seshadri, Sudha; Murabito, Joanne M (BioMed Central, 2007-9-19)
    BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS: We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) ...
  • Sherva, Richard; Sripichai, Orapan; Abel, Kenneth; Ma, Qianli; Whitacre, Johanna; Angkachatchai, Vach; Makarasara, Wattanan; Winichagoon, Pranee; Svasti, Saovaros; Fucharoen, Suthat; Braun, Andreas; Farrer, Lindsay A (BioMed Central, 2010-3-30)
    BACKGROUND: Patients with Hb E/β0 thalassemia display remarkable variability in disease severity. To identify genetic modifiers influencing disease severity, we conducted a two-stage genome scan in groups of 207 mild and ...
  • Cupples, L Adrienne; Heard-Costa, Nancy; Lee, Monica; Atwood, Larry D (BioMed Central, 2009-12-15)
    Genetic Analysis Workshop 16 (GAW16) Problem 2 presented data from the Framingham Heart Study (FHS), an observational, prospective study of risk factors for cardiovascular disease begun in 1948. Data have been collected ...
  • Yang, Qiong; Kathiresan, Sekar; Lin, Jing-Ping; Tofler, Geoffrey H; O'Donnell, Christopher J (BioMed Central, 2007-9-19)
    BACKGROUND: Increased circulating levels of hemostatic factors as well as anemia have been associated with increased risk of cardiovascular disease (CVD). Known associations between hemostatic factors and sequence variants ...
  • Hendricks, Audrey E; Zhu, Yanyan; Dupuis, Josée (BioMed Central, 2009-12-15)
    Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a ...
  • Hwang, Shih-Jen; Yang, Qiong; Meigs, James B; Pearce, Elizabeth N; Fox, Caroline S (BioMed Central, 2007-9-19)
    BACKGROUND: Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) are markers of kidney function that are known to be heritable. Many endocrine conditions have strong familial components. We tested for ...
  • Meyer, Tamra E.; Verwoert, Germaine C.; Hwang, Shih-Jen; Glazer, Nicole L.; Smith, Albert V.; van Rooij, Frank J. A.; Ehret, Georg B.; Boerwinkle, Eric; Felix, Janine F.; Leak, Tennille S.; Harris, Tamara B.; Yang, Qiong; Dehghan, Abbas; Aspelund, Thor; Katz, Ronit; Homuth, Georg; Kocher, Thomas; Rettig, Rainer; Ried, Janina S.; Gieger, Christian; Prucha, Hanna; Pfeufer, Arne; Meitinger, Thomas; Coresh, Josef; Hofman, Albert; Sarnak, Mark J.; Chen, Yii-Der Ida; Uitterlinden, André G.; Chakravarti, Aravinda; Psaty, Bruce M.; van Duijn, Cornelia M.; Kao, W. H. Linda; Witteman, Jacqueline C. M.; Gudnason, Vilmundur; Siscovick, David S.; Fox, Caroline S.; Köttgen, Anna (Public Library of Science, 2010-8-5)
    Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure ...
  • Kathiresan, Sekar; Manning, Alisa; Demissie, Serkalem; D'Agostino, Ralph; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Burtt, Noel; Melander, Olle; Orho-Melander, Marju; et al. (2007)
    BACKGROUND:Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-wide association is a ...

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