URI: http://hdl.handle.net/2144/974

Biomedical engineering is advancing rapidly and producing important innovations that improve our quality of life. From understanding the human genome to pioneering surgical tools, Boston University biomedical engineers are committed the advancement of research and education in biotechnology, biomolecular engineering, sensory systems, cardiopulmonary engineering, neuroscience, micro-and nano-systems and biomechanics and biomaterials.

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Biomedical Engineering
John A. White, Ph.D., Chairman
44 Cummington St., Room 403
Phone: (617) 353-2805
Fax: (617) 353-6766

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  • Awareness, interest, and preferences of primary care providers in using point-of-care cancer screening technology 

    Vanture, Sarah; Cho, Margaret; Wang, Catharine; Klapperich, Catherine; Huang, Franklin W.; Kim, Chloe S. (2016-01-15)
    Well-developed point-of-care (POC) cancer screening tools have the potential to provide better cancer care to patients in both developed and developing countries. However, new medical technology will not be adopted by ...
  • Microfluidic chip for molecular amplification of influenza A RNA in human respiratory specimens 

    Mahalanabis, Madhumita; Chang, Jessie; Carey, Brendan; Hsieh, Christopher; Stanley, Ahjegannie; Feldman, James; Mitchell, Patricia; Klapperich, Catherine; Odell, Christine A.; Pollock, Nira R.; Qingqing, Cao (2012-03-22)
    A rapid, low cost, accurate point-of-care (POC) device to detect influenza virus is needed for effective treatment and control of both seasonal and pandemic strains. We developed a single-use microfluidic chip that integrates ...
  • On the Choice and Number of Microarrays for Transcriptional Regulatory Network Inference 

    Cosgrove, Elissa J.; Gardner, Timothy S.; Kolaczyk, Eric D. (BioMed Central, 2010-9-9)
    BACKGROUND. Transcriptional regulatory network inference (TRNI) from large compendia of DNA microarrays has become a fundamental approach for discovering transcription factor (TF)-gene interactions at the genome-wide level. ...
  • Distinct Functions for the Drosophila piRNA Pathway in Genome Maintenance and Telomere Protection 

    Khurana, Jaspreet S.; Xu, Jia; Weng, Zhiping; Theurkauf, William E. (Public Library of Science, 2010-12-16)
    Transposons and other selfish DNA elements can be found in all phyla, and mobilization of these elements can compromise genome integrity. The piRNA (PIWI-interacting RNA) pathway silences transposons in the germline, but ...
  • Portraits of Breast Cancer Progression 

    Dalgin, Gul S.; Alexe, Gabriela; Scanfeld, Daniel; Tamayo, Pablo; Mesirov, Jill P.; Ganesan, Shridar; DeLisi, Charles; Bhanot, Gyan (BioMed Central, 2007-8-6)
    BACKGROUND. Clustering analysis of microarray data is often criticized for giving ambiguous results because of sensitivity to data perturbation or clustering techniques used. In this paper, we describe a new method based ...
  • Tuning and Controlling Gene Expression Noise in Synthetic Gene Networks 

    Murphy, Kevin F.; Adams, Rhys M.; Wang, Xiao; Balázsi, Gábor; Collins, James J. (Oxford University Press, 2010-03-08)
    Synthetic gene networks can be used to control gene expression and cellular phenotypes in a variety of applications. In many instances, however, such networks can behave unreliably due to gene expression noise. Accordingly, ...
  • Base-Stacking and Base-Pairing Contributions into Thermal Stability of the DNA Double Helix 

    Yakovchuk, Peter; Protozanova, Ekaterina; Frank-Kamenetskii, Maxim D. (Oxford University Press, 2006-01-31)
    Two factors are mainly responsible for the stability of the DNA double helix: base pairing between complementary strands and stacking between adjacent bases. By studying DNA molecules with solitary nicks and gaps we measure ...
  • Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains 

    Ku, Manching; Koche, Richard P.; Rheinbay, Esther; Mendenhall, Eric M.; Endoh, Mitsuhiro; Mikkelsen, Tarjei S.; Presser, Aviva; Nusbaum, Chad; Xie, Xiaohui; Chi, Andrew S.; Adli, Mazhar; Kasif, Simon; Ptaszek, Leon M.; Cowan, Chad A.; Lander, Eric S.; Koseki, Haruhiko; Bernstein, Bradley E. (Public Library of Science, 2008-10-31)
    In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 ...
  • Molecular Weight Assessment of Proteins in Total Proteome Profiles using 1D-PAGE and LC/MS/MS 

    Ahmad, Q. Rushdy; Nguyen, Dat H.; Wingerd, Mark A.; Church, George M.; Steffen, Martin A. (BioMed Central, 2005-6-8)
    BACKGROUND. The observed molecular weight of a protein on a 1D polyacrylamide gel can provide meaningful insight into its biological function. Differences between a protein's observed molecular weight and that predicted ...
  • The Insulator Binding Protein CTCF Positions 20 Nucleosomes around Its Binding Sites across the Human Genome 

    Fu, Yutao; Sinha, Manisha; Peterson, Craig L.; Weng, Zhiping (Public Library of Science, 2008-7-25)
    Chromatin structure plays an important role in modulating the accessibility of genomic DNA to regulatory proteins in eukaryotic cells. We performed an integrative analysis on dozens of recent datasets generated by ...
  • Labeling of Unique Sequences in Double-Stranded DNA at Sites of Vicinal Nicks Generated by Nicking Endonucleases 

    Kuhn, Heiko; Frank-Kamenetskii, Maxim D. (Oxford University Press, 2008-4)
    We describe a new approach for labeling of unique sequences within dsDNA under nondenaturing conditions. The method is based on the site-specific formation of vicinal nicks, which are created by nicking endonucleases ...
  • Biological Process Linkage Networks 

    Dotan-Cohen, Dikla; Letovsky, Stan; Melkman, Avraham A.; Kasif, Simon (Public Library of Science, 2009-4-23)
    BACKGROUND. The traditional approach to studying complex biological networks is based on the identification of interactions between internal components of signaling or metabolic pathways. By comparison, little is known ...
  • COMBREX: A Project to Accelerate the Functional Annotation of Prokaryotic Genomes 

    Roberts, Richard J.; Chang, Yi-Chien; Hu, Zhenjun; Rachlin, John N.; Anton, Brian P.; Pokrzywa, Revonda M.; Choi, Han-Pil; Faller, Lina L.; Guleria, Jyotsna; Housman, Genevieve; Klitgord, Niels; Mazumdar, Varun; McGettrick, Mark G.; Osmani, Lais; Swaminathan, Rajeswari; Tao, Kevin R.; Letovsky, Stan; Vitkup, Dennis; Segrè, Daniel; Salzberg, Steven L.; DeLisi, Charles; Steffen, Martin; Kasif, Simon (2010-11-20)
    COMBREX (http://combrex.bu.edu) is a project to increase the speed of the functional annotation of new bacterial and archaeal genomes. It consists of a database of functional predictions produced by computational biologists ...
  • PRECISE: A Database of Predicted and Consensus Interaction Sites in Enzymes 

    Sheu, Shu-Hsien; Lancia, David R.; Clodfelter, Karl H.; Landon, Melissa R.; Vajda, Sandor (Oxford University Press, 2004-12-17)
    PRECISE (Predicted and Consensus Interaction Sites in Enzymes) is a database of interactions between the amino acid residues of an enzyme and its ligands (substrate and transition state analogs, cofactors, inhibitors and ...
  • Comparative Genomic Characterization of Francisella tularensis Strains Belonging to Low and High Virulence Subspecies 

    Champion, Mia D.; Zeng, Qiandong; Nix, Eli B.; Nano, Francis E.; Keim, Paul; Kodira, Chinnappa D.; Borowsky, Mark; Young, Sarah; Koehrsen, Michael; Engels, Reinhard; Pearson, Matthew; Howarth, Clint; Larson, Lisa; White, Jared; Alvarado, Lucia; Forsman, Mats; Bearden, Scott W.; Sjöstedt, Anders; Titball, Richard; Michell, Stephen L.; Birren, Bruce; Galagan, James (Public Library of Science Pathogens, 2009-5-29)
    Tularemia is a geographically widespread, severely debilitating, and occasionally lethal disease in humans. It is caused by infection by a gram-negative bacterium, Francisella tularensis. In order to better understand its ...
  • Comparative Assessment of Performance and Genome Dependence among Phylogenetic Profiling Methods 

    Snitkin, Evan S.; Gustafson, Adam M.; Mellor, Joseph; Wu, Jie; DeLisi, Charles (BioMed Central, 2006-9-27)
    BACKGROUND. The rapidly increasing speed with which genome sequence data can be generated will be accompanied by an exponential increase in the number of sequenced eukaryotes. With the increasing number of sequenced ...
  • Protein Evolution in Yeast Transcription Factor Subnetworks 

    Wang, Yong; Franzosa, Eric A.; Zhang, Xiang-Sun; Xia, Yu (Oxford University Press, 2010-5-13)
    When averaged over the full yeast protein–protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased ...
  • Long-Range Correlations in Rectal Temperature Fluctuations of Healthy Infants during Maturation 

    Stern, Georgette; Beel, Julia; Suki, Béla; Silverman, Mike; Westaway, Jenny; Cernelc, Mateja; Baldwin, David; Frey, Urs (Public Library of Science, 2009-7-29)
    BACKGROUND. Control of breathing, heart rate, and body temperature are interdependent in infants, where instabilities in thermoregulation can contribute to apneas or even life-threatening events. Identifying abnormalities ...
  • Methods for Dichoptic Stimulus Presentation in Functional Magnetic Resonance Imaging - A Review 

    Choubey, Bhaskar; Jurcoane, Alina; Muckli, Lars; Sireteanu, Ruxandra (Bentham Open, 2009-4-1)
    Dichoptic stimuli (different stimuli displayed to each eye) are increasingly being used in functional brain imaging experiments using visual stimulation. These studies include investigation into binocular rivalry, interocular ...
  • Biological Context Networks: A Mosaic View of the Interactome 

    Rachlin, John; Cohen, Dikla Dotan; Cantor, Charles; Kasif, Simon (2006-11-28)
    Network models are a fundamental tool for the visualization and analysis of molecular interactions occurring in biological systems. While broadly illuminating the molecular machinery of the cell, graphical representations ...

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