OpenBU

Browsing Biomedical Engineering by Title

OpenBU

Browsing Biomedical Engineering by Title

Sort by: Order: Results:

  • Anton, Brian P.; Russell, Susan P.; Vertrees, Jason; Kasif, Simon; Raleigh, Elisabeth A.; Limbach, Patrick A.; Roberts, Richard J. (2010-5-14)
    Methylthiotransferases (MTTases) are a closely related family of proteins that perform both radical-S-adenosylmethionine (SAM) mediated sulfur insertion and SAM-dependent methylation to modify nucleic acid or protein targets ...
  • Wu, Chang-Jiun; Kasif, Simon (Oxford University Press, 2005-06-27)
    The advent of microarray technology has revolutionized the search for genes that are differentially expressed across a range of cell types or experimental conditions. Traditional clustering methods, such as hierarchical ...
  • Wu, Jie; Hu, Zhenjun; DeLisi, Charles (BioMed Central, 2006-2-17)
    BACKGROUND. Phylogenetic analysis is emerging as one of the most informative computational methods for the annotation of genes and identification of evolutionary modules of functionally related genes. The effectiveness ...
  • Lee, Soohyun; Kohane, Isaac; Kasif, Simon (2005)
    BACKGROUND:Recent advances in genome sequencing suggest a remarkable conservation in gene content of mammalian organisms. The similarity in gene repertoire present in different organisms has increased ...
  • Lee, Soohyun; Kohane, Isaac; Kasif, Simon (BioMed Central, 2005-11-27)
    BACKGROUND: Recent advances in genome sequencing suggest a remarkable conservation in gene content of mammalian organisms. The similarity in gene repertoire present in different organisms has increased interest in studying ...
  • Ku, Manching; Koche, Richard P.; Rheinbay, Esther; Mendenhall, Eric M.; Endoh, Mitsuhiro; Mikkelsen, Tarjei S.; Presser, Aviva; Nusbaum, Chad; Xie, Xiaohui; Chi, Andrew S.; Adli, Mazhar; Kasif, Simon; Ptaszek, Leon M.; Cowan, Chad A.; Lander, Eric S.; Koseki, Haruhiko; Bernstein, Bradley E. (Public Library of Science, 2008-10-31)
    In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 ...
  • Dwyer, Daniel J; Kohanski, Michael A; Hayete, Boris; Collins, James J (2007)
    Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase-catalyzed strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase inhibitors, which trap ...
  • Dwyer, Daniel J; Kohanski, Michael A; Hayete, Boris; Collins, James J (2007-03-13)
    Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase-catalyzed strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase inhibitors, which trap the gyrase ...
  • Upile, Tahwinder; Jerjes, Waseem; Sterenborg, Henricus JCM; El-Naggar, Adel K; Sandison, Ann; Witjes, Max JH; Biel, Merrill A; Bigio, Irving; Wong, Brian JF; Gillenwater, Ann; MacRobert, Alexander J; Robinson, Dominic J; Betz, Christian S; Stepp, Herbert; Bolotine, Lina; McKenzie, Gordon; Mosse, Charles Alexander; Barr, Hugh; Chen, Zhongping; Berg, Kristian; D'Cruz, Anil K; Stone, Nicholas; Kendall, Catherine; Fisher, Sheila; Leunig, Andreas; Olivo, Malini; Richards-Kortum, Rebecca; Soo, Khee Chee; Bagnato, Vanderlei; Choo-Smith, Lin-Ping; Svanberg, Katarina; Tan, I Bing; Wilson, Brian C; Wolfsen, Herbert; Yodh, Arjun G; Hopper, Colin (BioMed Central, 2009-07-13)
    Review paper and Proceedings of the Inaugural Meeting of the Head and Neck Optical Diagnostics Society (HNODS) on March 14th 2009 at University College London. The aim of our research must be to provide breakthrough ...
  • Lehár, Joseph; Krueger, Andrew; Zimmermann, Grant; Borisy, Alexis (Nature Publishing Group, 2008-08-05)
    Biological systems are robust, in that they can maintain stable phenotypes under varying conditions or attacks. Biological systems are also complex, being organized into many functional modules that communicate through ...
  • Xi, Hualin; Shulha, Hennady P; Lin, Jane M; Vales, Teresa R; Fu, Yutao; Bodine, David M; McKay, Ronald D. G; Chenoweth, Josh G; Tesar, Paul J; Furey, Terrence S; Ren, Bing; Weng, Zhiping; Crawford, Gregory E (Public Library of Science, 2007-8-17)
    The identification of regulatory elements from different cell types is necessary for understanding the mechanisms controlling cell type–specific and housekeeping gene expression. Mapping DNaseI hypersensitive (HS) sites ...
  • Dalgin, Gul S.; Holloway, Dustin T.; Liou, Louis S.; DeLisi, Charles (Libertas Academica, 2007-2-9)
    Microarray gene expression profiling has been used to distinguish histological subtypes of renal cell carcinoma (RCC), and consequently to identify specific tumor markers. The analytical procedures currently in use find ...
  • Hung, Jui-Hung; Whitfield, Troy W; Yang, Tun-Hsiang; Hu, Zhenjun; Weng, Zhiping; DeLisi, Charles (BioMed Central, 2010-02-26)
    A gene set enrichment analysis method for including network topology in the identification of genes involved in phenotypic alterations is described. One of the important challenges to post-genomic biology is relating ...
  • Srivastava, Shireesh; Li, Zheng; Yang, Xuerui; Yedwabnick, Matthew; Shaw, Stephen; Chan, Christina (BioMed Central, 2007-10-9)
    BACKGROUND: In order to devise efficient treatments for complex, multi-factorial diseases, it is important to identify the genes which regulate multiple cellular processes. Exposure to elevated levels of free fatty acids ...
  • Vazquez, Alexei; Beg, Qasim K; deMenezes, Marcio A; Ernst, Jason; Bar-Joseph, Ziv; Barabási, Albert-László; Boros, László G; Oltvai, Zoltán N (BioMed Central, 2008-1-23)
    BACKGROUND. Obtaining quantitative predictions for cellular metabolic activities requires the identification and modeling of the physicochemical constraints that are relevant at physiological growth conditions. Molecular ...
  • Weng, Zhiping; Guigó, Roderic (BioMed Central, 2008-02-25)
    A report of the 6th Georgia Tech-Oak Ridge National Lab International Conference on Bioinformatics 'In silico Biology: Gene Discovery and Systems Genomics', Atlanta, USA, 15-17 November, 2007.
  • Fu, Yutao; Sinha, Manisha; Peterson, Craig L.; Weng, Zhiping (Public Library of Science, 2008-7-25)
    Chromatin structure plays an important role in modulating the accessibility of genomic DNA to regulatory proteins in eukaryotic cells. We performed an integrative analysis on dozens of recent datasets generated by ...
  • Park, Peter J.; Kong, Sek Won; Tebaldi, Toma; Lai, Weil R.; Kasif, Simon; Kohane, Isaac S. (Oxford University Press, 2009-9-28)
    Motivation: Type 2 diabetes is a chronic metabolic disease that involves both environmental and genetic factors. To understand the genetics of type 2 diabetes and insulin resistance, the DIabetes Genome Anatomy Project ...
  • Jiang, Xiaoyu; Nariai, Naoki; Steffen, Martin; Kasif, Simon; Kolaczyk, Eric D (BioMed Central, 2008-8-22)
    BACKGROUND. In the current climate of high-throughput computational biology, the inference of a protein's function from related measurements, such as protein-protein interaction relations, has become a canonical task. Most ...
  • Colijn, Caroline; Brandes, Aaron; Zucker, Jeremy; Lun, Desmond S.; Weiner, Brian; Farhat, Maha R.; Cheng, Tan-Yun; Moody, D. Branch; Murray, Megan; Galagan, James E. (Public Library of Science, 2009-8-28)
    Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its importance, the ability to study metabolism at a global scale using genomic technologies is limited. ...

Search OpenBU


Browse

Deposit Materials

Statistics