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Browsing Mathematics and Statistics by Title

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  • Chen, Ming-Huei; Cui, Jing; Guo, Chao-Yu; Cupples, L Adrienne; Van Eerdewegh, Paul; Dupuis, Josée; Yang, Qiong (BioMed Central, 2007-12-18)
    There has been a growing interest in developing strategies for identifying single-nucleotide polymorphisms (SNPs) that explain a linkage signal by joint modeling of linkage and association. We compare several existing ...
  • Fox, Caroline S.; Pencina, Michael J.; Wilson, Peter W.F.; Paynter, Nina P.; Vasan, Ramachandran S.; D'Agostino, Ralph B. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS: Participants were drawn from the original and offspring cohorts ...
  • Holloway, Dustin T.; Kon, Mark; DeLisi, Charles (Kluwer Academic Publishers, 2006-10-31)
    High throughput technologies, including array-based chromatin immunoprecipitation, have rapidly increased our knowledge of transcriptional maps-the identity and location of regulatory binding sites within genomes. Still, ...
  • Wolongevicz, Dolores M.; Zhu, Lei; Pencina, Michael J.; Kimokoti, Ruth W.; Newby, P. K.; D'Agostino, Ralph B.; Millen, Barbara E. (Hindawi Publishing Corporation, 2010-1-5)
    Background. Links between dietary quality and abdominal obesity are poorly understood. Objective. To examine the association between an obesity-specific dietary quality index and abdominal obesity risk in women. Methods. ...
  • Cosgrove, Elissa J; Gardner, Timothy S; Kolaczyk, Eric D (BioMed Central, 2010-9-9)
    BACKGROUND. Transcriptional regulatory network inference (TRNI) from large compendia of DNA microarrays has become a fundamental approach for discovering transcription factor (TF)-gene interactions at the genome-wide level. ...
  • Pou, Karla M.; Massaro, Joseph M.; Hoffmann, Udo; Lieb, Kathrin; Vasan, Ramachandran S.; O'Donnell, Christopher J.; Fox, Caroline S. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: The prevalence of abdominal obesity exceeds that of general obesity. We sought to determine the prevalence of abdominal subcutaneous and visceral obesity and to characterize the different patterns of fat ...
  • Roopun, Anita K.; Kramer, Mark A.; Carracedo, Lucy M.; Kaiser, Marcus; Davies, Ceri H.; Traub, Roger D.; Kopell, Nancy J.; Whittington, Miles A. (Frontiers Research Foundation, 2008-04-08)
    The neocortex generates rhythmic electrical activity over a frequency range covering many decades. Specific cognitive and motor states are associated with oscillations in discrete frequency bands within this range, but it ...
  • Levy, Daniel; DePalma, Steven R; Benjamin, Emelia J; O'Donnell, Christopher J; Parise, Helen; Hirschhorn, Joel N; Vasan, Ramachandran S; Izumo, Seigo; Larson, Martin G (BioMed Central, 2006-5-22)
    BACKGROUND: High-throughput genotyping generates vast amounts of data for analysis; results can be difficult to summarize succinctly. A single project may involve genotyping many genes with multiple variants per gene and ...
  • Yang, Qiong; Cui, Jing; Chazaro, Irmarie; Cupples, L Adrienne; Demissie, Serkalem (BioMed Central, 2005-12-30)
    In genome-wide genetic studies with a large number of markers, balancing the type I error rate and power is a challenging issue. Recently proposed false discovery rate (FDR) approaches are promising solutions to this ...
  • Nariai, Naoki; Kolaczyk, Eric D.; Kasif, Simon (Public Library of Science, 2007-3-28)
    Dramatic improvements in high throughput sequencing technologies have led to a staggering growth in the number of predicted genes. However, a large fraction of these newly discovered genes do not have a functional assignment. ...
  • Sam, Susan; Haffner, Steven; Davidson, Michael H.; D'Agostino, Ralph B.; Feinstein, Steven; Kondos, George; Perez, Alfonso; Mazzone, Theodore (American Diabetes Association, 2009-2-19)
    OBJECTIVE: Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) have been linked to systemic inflammation in nondiabetic cohorts. We examined the relationships between VAT and SAT and systemic inflammatory ...
  • Sam, Susan; Haffner, Steven; Davidson, Michael H.; D'Agostino, Ralph B.; Feinstein, Steven; Kondos, George; Perez, Alfonso; Mazzone, Theodore (American Diabetes Association, 2011-12-29)
    OBJECTIVE: Insulin resistance and type 2 diabetes are associated with an atherogenic lipoprotein profile. We examined the role of visceral and subcutaneous fat depots, independent of BMI, on the dyslipidemia associated ...
  • Kramer, Mark A.; Roopun, Anita K.; Carracedo, Lucy M.; Traub, Roger D.; Whittington, Miles A.; Kopell, Nancy J. (Public Library of Science, 2008-9-5)
    Rhythmic voltage oscillations resulting from the summed activity of neuronal populations occur in many nervous systems. Contemporary observations suggest that coexistent oscillations interact and, in time, may switch in ...
  • Ducrocq, Gregory; Wallace, Joshua S.; Baron, Gabriel; Ravaud, Philippe; Alberts, Mark J.; Wilson, Peter W.F.; Ohman, Erik Magnus; Brennan, Danielle M.; D'Agostino, Ralph B.; Bhatt, Deepak L.; Steg, Philippe Gabriel (Oxford University Press, 2010-02-24)
    AIMS. To develop a risk score to quantify bleeding risk in outpatients with or at risk of atherothrombosis. METHODS AND RESULTS. We studied patients in the REACH Registry, a cohort of 68 236 patients with/at risk of ...
  • Roopun, Anita K.; Kramer, Mark A.; Carracedo, Lucy M.; Kaiser, Marcus; Davies, Ceri H.; Traub, Roger D.; Kopell, Nancy J.; Whittington, Miles A. (Frontiers Research Foundation, 2008-12-15)
    Multiple local neuronal circuits support different, discrete frequencies of network rhythm in neocortex. Relationships between different frequencies correspond to mechanisms designed to minimise interference, couple activity ...
  • Chen, Ming-Huei; Larson, Martin G; Hsu, Yi-Hsiang; Peloso, Gina M; Guo, Chao-Yu; Fox, Caroline S; Atwood, Larry D; Yang, Qiong (BioMed Central, 2010-5-14)
    BACKGROUND. Genome-wide association (GWA) studies that use population-based association approaches may identify spurious associations in the presence of population admixture. In this paper, we propose a novel three-stage ...

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