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  • A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Kathiresan, Sekar; Manning, Alisa; Demissie, Serkalem; D'Agostino, Ralph; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Burtt, Noel; Melander, Olle; Orho-Melander, Marju; et al. (2007)
    BACKGROUND:Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-wide association is a ...
  • Genomewide Association Study for Onset Age in Parkinson Disease
    Latourelle, Jeanne C; Pankratz, Nathan; Dumitriu, Alexandra; Wilk, Jemma B; Goldwurm, Stefano; Pezzoli, Gianni; Mariani, Claudio B; DeStefano, Anita L; Halter, Cheryl; Gusella, James F; Nichols, William C; Myers, Richard H; Foroud, Tatiana (BioMed Central, 2009-9-22)
    BACKGROUND: Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age ...
  • Genome-Wide Association Study for Renal Traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Kottgen, Anna; Kao, Wen Hong L; Hwang, Shih-Jen; Boerwinkle, Eric; Yang, Qiong; Levy, Daniel; Benjamin, Emelia J; Larson, Martin G; Astor, Brad C; Coresh, Josef; Fox, Caroline S (BioMed Central, 2008-6-3)
    BACKGROUND: The Framingham Heart Study (FHS) recently obtained initial results from the first genome-wide association scan for renal traits. The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants ...
  • Genome-Wide Association Study for Subclinical Atherosclerosis in Major Arterial Territories in the NHLBI's Framingham Heart Study
    O'Donnell, Christopher J; Cupples, L Adrienne; D'Agostino, Ralph B; Fox, Caroline S; Hoffmann, Udo; Hwang, Shih-Jen; Ingellson, Erik; Liu, Chunyu; Murabito, Joanne M; Polak, Joseph F; Wolf, Philip A; Demissie, Serkalem (BioMed Central, 2007-9-19)
    INTRODUCTION: Subclinical atherosclerosis (SCA) measures in multiple arterial beds are heritable phenotypes that are associated with increased incidence of cardiovascular disease. We conducted a genome-wide association ...
  • Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    O'Donnell, Christopher; Cupples, L Adrienne; D'Agostino, Ralph; Fox, Caroline; Hoffmann, Udo; Hwang, Shih-Jen; Ingellson, Erik; Liu, Chunyu; Murabito, Joanne; Polak, Joseph; et al. (2007)
    INTRODUCTION:Subclinical atherosclerosis (SCA) measures in multiple arterial beds are heritable phenotypes that are associated with increased incidence of cardiovascular disease. We conducted a genome-wide ...
  • A Genome-Wide Association Study of Breast and Prostate Cancer in the NHLBI's Framingham Heart Study
    Murabito, Joanne M; Rosenberg, Carol L; Finger, Daniel; Kreger, Bernard E; Levy, Daniel; Splansky, Greta Lee; Antman, Karen; Hwang, Shih-Jen (BioMed Central, 2007-9-19)
    BACKGROUND: Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified. METHODS: We conducted a ...
  • Genome-Wide Association Study of Electrocardiographic and Heart Rate Variability Traits: the Framingham Heart Study
    Newton-Cheh, Christopher; Guo, Chao-Yu; Wang, Thomas J; O'Donnell, Christopher J; Levy, Daniel; Larson, Martin G (BioMed Central, 2007-9-19)
    BACKGROUND: Heritable electrocardiographic (ECG) and heart rate variability (HRV) measures, reflecting pacemaking, conduction, repolarization and autonomic function in the heart have been associated with risks for cardiac ...
  • A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans
    Adeyemo, Adebowale; Gerry, Norman; Chen, Guanjie; Herbert, Alan; Doumatey, Ayo; Huang, Hanxia; Zhou, Jie; Lashley, Kerrie; Chen, Yuanxiu; Christman, Michael; Rotimi, Charles (Public Library of Science, 2009-7-17)
    The evidence for the existence of genetic susceptibility variants for the common form of hypertension ("essential hypertension") remains weak and inconsistent. We sought genetic variants underlying blood pressure (BP) by ...
  • A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study
    Wilk, Jemma B.; Chen, Ting-hsu; Gottlieb, Daniel J.; Walter, Robert E.; Nagle, Michael W.; Brandler, Brian J.; Myers, Richard H.; Borecki, Ingrid B.; Silverman, Edwin K.; Weiss, Scott T.; O'Connor, George T. (Public Library of Science, 2009-3-20)
    The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ...
  • A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
    Richards, J. Brent; Waterworth, Dawn; O'Rahilly, Stephen; Hivert, Marie-France; Loos, Ruth J. F.; Perry, John R. B.; Tanaka, Toshiko; Timpson, Nicholas John; Semple, Robert K.; Soranzo, Nicole; Song, Kijoung; Rocha, Nuno; Grundberg, Elin; Dupuis, Josée; Florez, Jose C.; Langenberg, Claudia; Prokopenko, Inga; Saxena, Richa; Sladek, Robert; Aulchenko, Yurii; Evans, David; Waeber, Gerard; Erdmann, Jeanette; Burnett, Mary-Susan; Sattar, Naveed; Devaney, Joseph; Willenborg, Christina; Hingorani, Aroon; Witteman, Jaquelin C. M.; Vollenweider, Peter; Glaser, Beate; Hengstenberg, Christian; Ferrucci, Luigi; Melzer, David; Stark, Klaus; Deanfield, John; Winogradow, Janina; Grassl, Martina; Hall, Alistair S.; Egan, Josephine M.; Thompson, John R.; Ricketts, Sally L.; König, Inke R.; Reinhard, Wibke; Grundy, Scott; Wichmann, H-Erich; Barter, Phil; Mahley, Robert; Kesaniemi, Y. Antero; Rader, Daniel J.; Reilly, Muredach P.; Epstein, Stephen E.; Stewart, Alexandre F. R.; Van Duijn, Cornelia M.; Schunkert, Heribert; Burling, Keith; Deloukas, Panos; Pastinen, Tomi; Samani, Nilesh J.; McPherson, Ruth; Davey Smith, George; Frayling, Timothy M.; Wareham, Nicholas J.; Meigs, James B.; Mooser, Vincent; Spector, Tim D. (Public Library of Science, 2009-12-11)
    The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for ...
  • Genome-Wide Association to Body Mass Index and Waist Circumference: The Framingham Heart Study 100K Project
    Fox, Caroline S; Heard-Costa, Nancy; Cupples, L Adrienne; Dupuis, Josée; Vasan, Ramachandran S; Atwood, Larry D (BioMed Central, 2007-9-19)
    BACKGROUND: Obesity is related to multiple cardiovascular disease (CVD) risk factors as well as CVD and has a strong familial component. We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures ...
  • Genome-Wide Association with Bone Mass and Geometry in the Framingham Heart Study
    Kiel, Douglas P; Demissie, Serkalem; Dupuis, Josée; Lunetta, Kathryn L; Murabito, Joanne M; Karasik, David (BioMed Central, 2007-9-19)
    BACKGROUND: Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits ...
  • Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Kiel, Douglas; Demissie, Serkalem; Dupuis, Josee; Lunetta, Kathryn; Murabito, Joanne; Karasik, David (2007)
    BACKGROUND:Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies ...
  • Genome-Wide Association with Diabetes-Related Traits in the Framingham Heart Study
    Meigs, James B; Manning, Alisa K; Fox, Caroline S; Florez, Jose C; Liu, Chunyu; Cupples, L Adrienne; Dupuis, Josée (BioMed Central, 2007-9-19)
    BACKGROUND: Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants. METHODS: We used the ...
  • Genome-Wide Association with Select Biomarker Traits in the Framingham Heart Study
    Benjamin, Emelia J; Dupuis, Josée; Larson, Martin G; Lunetta, Kathryn L; Booth, Sarah L; Govindaraju, Diddahally R; Kathiresan, Sekar; Keaney, John F; Keyes, Michelle J; Lin, Jing-Ping; Meigs, James B; Robins, Sander J; Rong, Jian; Schnabel, Renate; Vita, Joseph A; Wang, Thomas J; Wilson, Peter WF; Wolf, Philip A; Vasan, Ramachandran S (BioMed Central, 2007-9-19)
    BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provide ...
  • Genome-Wide Linkage Analysis for Alcohol Dependence: A Comparison between Single-Nucleotide Polymorphism and Microsatellite Marker Assays
    Ma, Qianli; Yu, Yi; Meng, Yan; Farrell, John; Farrer, Lindsay A; Wilcox, Marsha A (BioMed Central, 2005-12-30)
    Both theoretical and applied studies have proven that the utility of single nucleotide polymorphism (SNP) markers in linkage analysis is more powerful and cost-effective than current microsatellite marker assays. Here we ...
  • Genome-Wide Linkage and Association Scans for Quantitative Trait Loci of Serum Lactate Dehydrogenase-The Framingham Heart Study
    Lin, Jing-Ping; Zheng, Gang; Joo, Jungnam; Cupples, L. Adrienne (SAGE-Hindawi Access to Research, 2010-09-01)
    Serum lactate dehydrogenase (LDH) is used in diagnosing many diseases and is significantly determined by genetic factors. Three genes coding for LDH isoenzymes were mapped to chromosome 11q15 and 12p12. We used 330 Framingham ...
  • Genome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Network
    Linghu, Bolan; Snitkin, Evan S; Hu, Zhenjun; Xia, Yu; DeLisi, Charles (BioMed Central, 2009-09-03)
    An evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes. We integrate 16 genomic features to construct an ...
  • Genome-Wide Screen for Heavy Alcohol Consumption
    Wyszynski, Diego F; Panhuysen, Carolien I; Ma, Qianli; Yip, Agustin G; Wilcox, Marsha; Erlich, Porat; Farrer, Lindsay A (BioMed Central, 2003-12-31)
    BACKGROUND. To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected ...
  • Genome-Wide Significance for a Modifier of Age at Neurological Onset in Huntington's Disease at 6q23-24: The HD MAPS Study
    Li, Jian-Liang; Hayden, Michael R; Warby, Simon C; Durr, Alexandra; Morrison, Patrick J; Nance, Martha; Ross, Christopher A; Margolis, Russell L; Rosenblatt, Adam; Squitieri, Ferdinando; Frati, Luigi; Gómez-Tortosa, Estrella; García, Carmen Ayuso; Suchowersky, Oksana; Klimek, Mary Lou; Trent, Ronald JA; McCusker, Elizabeth; Novelletto, Andrea; Frontali, Marina; Paulsen, Jane S; Jones, Randi; Ashizawa, Tetsuo; Lazzarini, Alice; Wheeler, Vanessa C; Prakash, Ranjana; Xu, Gang; Djoussé, Luc; Mysore, Jayalakshmi Srinidhi; Gillis, Tammy; Hakky, Michael; Cupples, L Adrienne; Saint-Hilaire, Marie H; Cha, Jang-Ho J; Hersch, Steven M; Penney, John B; Harrison, Madaline B; Perlman, Susan L; Zanko, Andrea; Abramson, Ruth K; Lechich, Anthony J; Duckett, Ayana; Marder, Karen; Conneally, P Michael; Gusella, James F; MacDonald, Marcy E; Myers, Richard H (BioMed Central, 2006-8-17)
    BACKGROUND: Age at onset of Huntington's disease (HD) is correlated with the size of the abnormal CAG repeat expansion in the HD gene; however, several studies have indicated that other genetic factors also contribute to ...