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Browsing by Author "Baldwin, Clinton T"

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A Hierarchical and Modular Approach to the Discovery of Robust Associations in Genome-Wide Association Studies from Pooled DNA Samples

Sebastiani, Paola; Zhao, Zhenming; Abad-Grau, Maria M; Riva, Alberto; Hartley, Stephen W; Sedgewick, Amanda E; Doria, Alessandro; Montano, Monty; Melista, Efthymia; Terry, Dellara; Perls, Thomas T; Steinberg, Martin H; Baldwin, Clinton T (BioMed Central, 2008-1-14)

BACKGROUND: One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations. RESULTS. We present a ...
Imputation of Missing Genotypes: An Empirical Evaluation of IMPUTE

Zhao, Zhenming; Timofeev, Nadia; Hartley, Stephen W; Chui, David HK; Fucharoen, Supan; Perls, Thomas T; Steinberg, Martin H; Baldwin, Clinton T; Sebastiani, Paola (BioMed Central, 2008-12-12)

BACKGROUND: Imputation of missing genotypes is becoming a very popular solution for synchronizing genotype data collected with different microarray platforms but the effect of ethnic background, subject ascertainment, and ...
Lack of Association between Angiotensin-Converting Enzyme and Dementia of the Alzheimer's Type in an Elderly Arab Population in Wadi Ara, Israel

Bowirrat, Abdalla; Cui, Jing; Waraska, Kristin; Friedland, Robert P; Oscar-Berman, Marlene; Farrer, Lindsay A; Korczyn, Amos; Baldwin, Clinton T (Dove Medical Press, 2005)

The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer's disease (AD). This study investigated whether the ACE gene ...

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