Browsing by Author "Frank-Kamenetskii, Maxim D."

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Base-Stacking and Base-Pairing Contributions into Thermal Stability of the DNA Double Helix

Yakovchuk, Peter; Protozanova, Ekaterina; Frank-Kamenetskii, Maxim D. (Oxford University Press, 2006-01-31)

Two factors are mainly responsible for the stability of the DNA double helix: base pairing between complementary strands and stacking between adjacent bases. By studying DNA molecules with solitary nicks and gaps we measure ...
End Invasion of Peptide Nucleic Acids (PNAs) with Mixed-Base Composition into Linear DNA Duplexes

Smolina, Irina V.; Demidov, Vadim V.; Soldatenkov, Viatcheslav A.; Chasovskikh, Sergey G.; Frank-Kamenetskii, Maxim D. (Oxford University Press, 2005-10-04)

Peptide nucleic acid (PNA) is a synthetic DNA mimic with valuable properties and a rapidly growing scope of applications. With the exception of recently introduced pseudocomplementary PNAs, binding of common PNA oligomers ...
Labeling of Unique Sequences in Double-Stranded DNA at Sites of Vicinal Nicks Generated by Nicking Endonucleases

Kuhn, Heiko; Frank-Kamenetskii, Maxim D. (Oxford University Press, 2008-4)

We describe a new approach for labeling of unique sequences within dsDNA under nondenaturing conditions. The method is based on the site-specific formation of vicinal nicks, which are created by nicking endonucleases ...

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