Browsing by Author "Hu, Howard"

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Browsing by Author "Hu, Howard"

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  • Association Between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study
    Lampe, Brad J.; Park, Sung Kyun; Robins, Thomas; Mukherjee, Bhramar; Litonjua, Augusto A.; Amarasiriwardena, Chitra; Weisskopf, Marc; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2008-09)
    BACKGROUND. High levels of cadmium exposure are known to cause emphysema in occupationally exposed workers, but little has been reported to date on the association between chronic environmental cadmium exposure and pulmonary ...
  • Association of Cumulative Lead Exposure with Parkinson's Disease
    Weisskopf, Marc G.; Weuve, Jennifer; Nie, Huiling; Saint-Hilaire, Marie-Helene; Sudarsky, Lewis; Simon, David K.; Hersh, Bonnie; Schwartz, Joel; Wright, Robert O.; Hu, Howard (National Institute of Environmental Health Sciences, 2010-11)
    BACKGROUND. Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson's disease (PD), but the only study that used bone lead, a biomarker of ...
  • Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
    Wright, Robert O.; Schwartz, Joel; Wright, Rosalind J.; Bollati, Valentina; Tarantini, Letizia; Park, Sung Kyun; Hu, Howard; Sparrow, David; Vokonas, Pantel; Baccarelli, Andrea (National Institute of Environmental Health Sciences, 2010-06)
    BACKGROUND. DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...
  • Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study
    Perlstein, Todd; Weuve, Jennifer; Schwartz, Joel; Sparrow, David; Wright, Robert; Litonjua, Augusto; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007-12)
    BACKGROUND. Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...
  • Cumulative Lead Exposure and Tooth Loss in Men: The Normative Aging Study
    Arora, Manish; Weuve, Jennifer; Weisskopf, Marc G.; Sparrow, David; Nie, Huiling; Garcia, Raul I.; Hu, Howard (National Institute of Environmental Health Sciences, 2009-10)
    BACKGROUND. Individuals previously exposed to lead remain at risk because of endogenous release of lead stored in their skeletal compartments. However, it is not known if long-term cumulative lead exposure is a risk factor ...
  • HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study
    Zhang, Aimin; Park, Sung Kyun; Wright, Robert O.; Weisskopf, Marc G.; Mukherjee, Bhramar; Nie, Huiling; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2010-09)
    BACKGROUND. Cumulative lead exposure is associated with a widened pulse pressure (PP; the difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. ...
  • Interaction of Stress, Lead Burden, and Age on Cognition in Older Men: The VA Normative Aging Study
    Peters, Junenette L.; Weisskopf, Marc G.; Spiro, Avron; Schwartz, Joel; Sparrow, David; Nie, Huiling; Hu, Howard; Wright, Robert O.; Wright, Rosalind J. (National Institute of Environmental Health Sciences, 2010-04)
    BACKGROUND. Low-level exposure to lead and to chronic stress may independently influence cognition. However, the modifying potential of psychosocial stress on the neurotoxicity of lead and their combined relationship to ...
  • Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval
    Park, Sung Kyun; Hu, Howard; Wright, Robert O.; Schwartz, Joel; Cheng, Yawen; Sparrow, David; Vokonas, Pantel S.; Weisskopf, Marc G. (National Institute of Environmental Health Sciences, 2009-01)
    BACKGROUND. Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance ...
  • Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: the VA Normative Aging Study
    Jain, Nitin B.; Potula, Vijayalakshmi; Schwartz, Joel; Vokonas, Pantel S.; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007-06)
    BACKGROUND. Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes. OBJECTIVE. We assessed the association between bone ...
  • Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study
    Park, Sung Kyun; Schwartz, Joel; Weisskopf, Marc; Sparrow, David; Vokonas, Pantel S.; Wright, Robert O.; Coull, Brent; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2006-11)
    BACKGROUND. Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure. OBJECTIVE. We examined the association of low-level lead ...
  • Modifying Effects of the HFE Polymorphisms on the Association between Lead Burden and Cognitive Decline
    Wang, Florence T.; Hu, Howard; Schwartz, Joel; Weuve, Jennifer; Spiro, Avron S.; Sparrow, David; Nie, Huiling; Silverman, Edwin K.; Weiss, Scott T.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007-08)
    BACKGROUND. As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. OBJECTIVE. ...
  • Proton Magnetic Resonance Spectroscopic Evidence of Glial Effects of Cumulative Lead Exposure in the Adult Human Hippocampus
    Weisskopf, Marc G.; Hu, Howard; Sparrow, David; Lenkinski, Robert E.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007-4)
    BACKGROUND. Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans. OBJECTIVES. ...
  • Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study
    Peters, Junenette L.; Kubzansky, Laura; McNeely, Eileen; Schwartz, Joel; Spiro, Avron; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007-08)
    BACKGROUND. Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. OBJECTIVES. ...