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Browsing by Author "Lafyatis, Robert"

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Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype?

Fleming, Jo N.; Nash, Richard A.; McLeod, D. O.; Fiorentino, David F.; Shulman, Howard M.; Connolly, M. Kari; Molitor, Jerry A.; Henstorf, Gretchen; Lafyatis, Robert; Pritchard, David K.; Adams, Lawrence D.; Furst, Daniel E.; Schwartz, Stephen M. (Public Library of Science, 2008-1-16)

BACKGROUND. Scleroderma is an autoimmune disease with a characteristic vascular pathology. The vasculopathy associated with scleroderma is one of the major contributors to the clinical manifestations of the disease. ...
Fibrosis in Connective Tissue Disease: The Role of the Myofibroblast and Fibroblast-Epithelial Cell Interactions

Krieg, Thomas; Abraham, David; Lafyatis, Robert (BioMed Central, 2007-8-15)

Fibrosis, characterized by excessive extracellular matrix accumulation, is a common feature of many connective tissue diseases, notably scleroderma (systemic sclerosis). Experimental studies suggest that a complex network ...
Increased Frequency and Compromised Function of T Regulatory Cells in Systemic Sclerosis (SSc) Is Related to a Diminished CD69 and TGFβ Expression

Radstake, Timothy R. D. J.; van Bon, Lenny; Broen, Jasper; Wenink, Mark; Santegoets, Kim; Deng, Yanhui; Hussaini, Anila; Simms, Robert; Cruikshank, William W.; Lafyatis, Robert (Public Library of Science, 2009-6-22)

BACKGROUND. Regulatory T cells (Tregs) are essential in the control of tolerance. Evidence implicates Tregs in human autoimmune conditions. Here we investigated their role in systemic sclerosis (SSc). METHODS/PRINCIPAL ...
Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury

Pendergrass, Sarah A.; Hayes, Everett; Farina, Giuseppina; Lemaire, Raphael; Farber, Harrison W.; Whitfield, Michael L.; Lafyatis, Robert (Public Library of Science, 2010-8-17)

BACKGROUND. Pulmonary arterial hypertension (PAH) is a common complication for individuals with limited systemic sclerosis (lSSc). The identification and characterization of biomarkers for lSSc-PAH should lead to less ...
The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNϒ Distinguishes SSc Phenotypes

Radstake, Timothy R. D. J.; van Bon, Lenny; Broen, Jasper; Hussiani, Anila; Hesselstrand, Roger; Wuttge, Dirk M.; Deng, Yanhui; Simms, Robbert; Lubberts, Erik; Lafyatis, Robert (Public Library of Science, 2009-6-17)

BACKGROUND. Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. METHODOLOGY AND PRINCIPAL ...
Toll-Like Receptors and Innate Immune Responses in Systemic Lupus Erythematosus

Lafyatis, Robert; Marshak-Rothstein, Ann (BioMed Central, 2007-11-29)

A series of discoveries over the past several years has provided a new paradigm for understanding autoimmunity in systemic lupus erythematosus. The discoveries of pattern recognition receptors and of how these receptors ...

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