Browsing by Author "Samuel, Glady H"

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Autocrine Transforming Growth Factor β Signaling Regulates Extracellular Signal-regulated Kinase 1/2 Phosphorylation via Modulation of Protein Phosphatase 2A Expression in Scleroderma Fibroblasts

Samuel, Glady H; Bujor, Andreea M; Nakerakanti, Sashidhar S; Hant, Faye N; Trojanowska, Maria (BioMed Central, 2010-12-06)

BACKGROUND. During scleroderma (SSc) pathogenesis, fibroblasts acquire an activated phenotype characterized by enhanced production of extracellular matrix (ECM) and constitutive activation of several major signaling pathways ...

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