Browsing by Author "Timofeev, Nadia"

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Imputation of Missing Genotypes: An Empirical Evaluation of IMPUTE

Zhao, Zhenming; Timofeev, Nadia; Hartley, Stephen W; Chui, David HK; Fucharoen, Supan; Perls, Thomas T; Steinberg, Martin H; Baldwin, Clinton T; Sebastiani, Paola (BioMed Central, 2008-12-12)

BACKGROUND: Imputation of missing genotypes is becoming a very popular solution for synchronizing genotype data collected with different microarray platforms but the effect of ethnic background, subject ascertainment, and ...
Principal-Component-Based Population Structure Adjustment in the North American Rheumatoid Arthritis Consortium Data: Impact of Single-Nucleotide Polymorphism Set and Analysis Method

Peloso, Gina M; Timofeev, Nadia; Lunetta, Kathryn L (BioMed Central, 2009-12-15)

Population structure occurs when a sample is composed of individuals with different ancestries and can result in excess type I error in genome-wide association studies. Genome-wide principal-component analysis (PCA) has ...

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