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Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes

Larson, Martin; Atwood, Larry; Benjamin, Emelia; Cupples, L Adrienne; D'Agostino, Ralph; Fox, Caroline; Govindaraju, Diddahally; Guo, Chao-Yu; Heard-Costa, Nancy; Hwang, Shih-Jen; et al. (2007)

BACKGROUND:Cardiovascular disease (CVD) and its most common manifestations - including coronary heart disease (CHD), stroke, heart failure (HF), and atrial fibrillation (AF) - are major causes of morbidity ...
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

Cupples, L Adrienne; Arruda, Heather; Benjamin, Emelia; D'Agostino, Ralph; Demissie, Serkalem; DeStefano, Anita; Dupuis, Josee; Falls, Kathleen; Fox, Caroline; Gottlieb, Daniel; et al. (2007)

BACKGROUND:The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. ...
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

Lunetta, Kathryn; D'Agostino, Ralph; Karasik, David; Benjamin, Emelia; Guo, Chao-Yu; Govindaraju, Raju; Kiel, Douglas; Kelly-Hayes, Margaret; Massaro, Joseph; Pencina, Michael; et al. (2007)

BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS:We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for ...
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

Kathiresan, Sekar; Manning, Alisa; Demissie, Serkalem; D'Agostino, Ralph; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Burtt, Noel; Melander, Olle; Orho-Melander, Marju; et al. (2007)

BACKGROUND:Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-wide association is a ...
Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study

O'Donnell, Christopher; Cupples, L Adrienne; D'Agostino, Ralph; Fox, Caroline; Hoffmann, Udo; Hwang, Shih-Jen; Ingellson, Erik; Liu, Chunyu; Murabito, Joanne; Polak, Joseph; et al. (2007)

INTRODUCTION:Subclinical atherosclerosis (SCA) measures in multiple arterial beds are heritable phenotypes that are associated with increased incidence of cardiovascular disease. We conducted a genome-wide ...

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