Browsing by Author "van Bon, Lenny"

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Increased Frequency and Compromised Function of T Regulatory Cells in Systemic Sclerosis (SSc) Is Related to a Diminished CD69 and TGFβ Expression

Radstake, Timothy R. D. J.; van Bon, Lenny; Broen, Jasper; Wenink, Mark; Santegoets, Kim; Deng, Yanhui; Hussaini, Anila; Simms, Robert; Cruikshank, William W.; Lafyatis, Robert (Public Library of Science, 2009-6-22)

BACKGROUND. Regulatory T cells (Tregs) are essential in the control of tolerance. Evidence implicates Tregs in human autoimmune conditions. Here we investigated their role in systemic sclerosis (SSc). METHODS/PRINCIPAL ...
The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNϒ Distinguishes SSc Phenotypes

Radstake, Timothy R. D. J.; van Bon, Lenny; Broen, Jasper; Hussiani, Anila; Hesselstrand, Roger; Wuttge, Dirk M.; Deng, Yanhui; Simms, Robbert; Lubberts, Erik; Lafyatis, Robert (Public Library of Science, 2009-6-17)

BACKGROUND. Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. METHODOLOGY AND PRINCIPAL ...

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