Browsing Department of Biostatistics by Title

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Browsing Department of Biostatistics by Title

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  • Latourelle, Jeanne C; Sun, Mei; Lew, Mark F; Suchowersky, Oksana; Klein, Christine; Golbe, Lawrence I; Mark, Margery H; Growdon, John H; Wooten, G Frederick; Watts, Ray L; Guttman, Mark; Racette, Brad A; Perlmutter, Joel S; Ahmed, Anwar; Shill, Holly A; Singer, Carlos; Goldwurm, Stefano; Pezzoli, Gianni; Zini, Michela; Saint-Hilaire, Marie H; Hendricks, Audrey E; Williamson, Sally; Nagle, Michael W; Wilk, Jemma B; Massood, Tiffany; Huskey, Karen W; Laramie, Jason M; DeStefano, Anita L; Baker, Kenneth B; Itin, Ilia; Litvan, Irene; Nicholson, Garth; Corbett, Alastair; Nance, Martha; Drasby, Edward; Isaacson, Stuart; Burn, David J; Chinnery, Patrick F; Pramstaller, Peter P; Al-hinti, Jomana; Moller, Anette T; Ostergaard, Karen; Sherman, Scott J; Roxburgh, Richard; Snow, Barry; Slevin, John T; Cambi, Franca; Gusella, James F; Myers, Richard H (BioMed Central, 2008-11-5)
    BACKGROUND: We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2)-related Parkinson's disease (PD) in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser ...
  • Cho, Kelly; Yang, Qiong; Dupuis, Josée (BioMed Central, 2007-12-18)
    The presence of linkage disequilibrium violates the underlying assumption of linkage equilibrium in most traditional multipoint linkage approaches. Studies have shown that such violation leads to bias in qualitative trait ...
  • Cho, Kelly; Dupuis, Josée (BioMed Central, 2009-8-10)
    BACKGROUND. In affected sibling pair linkage analysis, the presence of linkage disequilibrium (LD) has been shown to lead to overestimation of the number of alleles shared identity-by-descent (IBD) among sibling pairs when ...
  • Stolerman, Elliot S.; Manning, Alisa K.; McAteer, Jarred B.; Dupuis, Josée; Fox, Caroline S.; Cupples, L. Adrienne; Meigs, James B.; Florez, Jose C. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: A recent meta-analysis demonstrated a nominal association of the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K→Q missense single nucleotide polymorphism (SNP) at position 121 with type 2 diabetes. ...
  • Sebastiani, Paola; Zhao, Zhenming; Abad-Grau, Maria M; Riva, Alberto; Hartley, Stephen W; Sedgewick, Amanda E; Doria, Alessandro; Montano, Monty; Melista, Efthymia; Terry, Dellara; Perls, Thomas T; Steinberg, Martin H; Baldwin, Clinton T (BioMed Central, 2008-1-14)
    BACKGROUND: One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations. RESULTS. We present a ...
  • Chen, Ming-Huei; Van Eerdewegh, Paul; Dupuis, Josée (BioMed Central, 2005-12-30)
    We applied three approaches for the identification of polymorphisms explaining the linkage evidence to the Genetic Analysis Workshop 14 simulated data: 1) the genotype-IBD sharing test (GIST); 2) an approach suggested by ...
  • Guo, Chao-Yu; Cui, Jing; Cupples, L Adrienne (BioMed Central, 2005-12-30)
    The transmission/disequilibrium test was introduced to test for linkage disequilibrium between a marker and a putative disease locus using case-parent trios. However, parental genotypes may be incomplete in such a study. ...
  • Walley, Alexander Y.; Krupitsky, Evgeny M.; Cheng, Debbie M.; Raj, Anita; Edwards, Erika M.; Bridden, Carly; Egorova, Valentina Y.; Zvartau, Edwin E.; Woody, George E.; Samet, Jeffrey H. (Springer US, 2007-5-9)
    Cannabis and heavy alcohol use potentially increase HIV transmission by increasing risky drug behaviors. We studied 404 subjects entering treatment for heroin dependence, in St. Petersburg, Russia. We used the HIV Risk ...
  • Zhao, Zhenming; Timofeev, Nadia; Hartley, Stephen W; Chui, David HK; Fucharoen, Supan; Perls, Thomas T; Steinberg, Martin H; Baldwin, Clinton T; Sebastiani, Paola (BioMed Central, 2008-12-12)
    BACKGROUND: Imputation of missing genotypes is becoming a very popular solution for synchronizing genotype data collected with different microarray platforms but the effect of ethnic background, subject ascertainment, and ...
  • Manning, Alisa K; Ngwa, Julius Suh; Hendricks, Audrey E; Liu, Ching-Ti; Johnson, Andrew D; Dupuis, Josée; Cupples, L Adrienne (BioMed Central, 2009-12-15)
    We sought to find significant gene × gene interaction in a genome-wide association analysis of rheumatoid arthritis (RA) by performing pair-wise tests of interaction among collections of single-nucleotide polymorphisms ...
  • Hsu, Yi-Hsiang; Zillikens, M. Carola; Wilson, Scott G.; Farber, Charles R.; Demissie, Serkalem; Soranzo, Nicole; Bianchi, Estelle N.; Grundberg, Elin; Liang, Liming; Richards, J. Brent; Estrada, Karol; Zhou, Yanhua; van Nas, Atila; Moffatt, Miriam F.; Zhai, Guangju; Hofman, Albert; van Meurs, Joyce B.; Pols, Huibert A. P.; Price, Roger I.; Nilsson, Olle; Pastinen, Tomi; Cupples, L. Adrienne; Lusis, Aldons J.; Schadt, Eric E.; Ferrari, Serge; Uitterlinden, André G.; Rivadeneira, Fernando; Spector, Timothy D.; Karasik, David; Kiel, Douglas P. (Public Library of Science, 2010-6-10)
    Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect ...
  • Chen, Ming-Huei; Cui, Jing; Guo, Chao-Yu; Cupples, L Adrienne; Van Eerdewegh, Paul; Dupuis, Josée; Yang, Qiong (BioMed Central, 2007-12-18)
    There has been a growing interest in developing strategies for identifying single-nucleotide polymorphisms (SNPs) that explain a linkage signal by joint modeling of linkage and association. We compare several existing ...
  • Bowirrat, Abdalla; Cui, Jing; Waraska, Kristin; Friedland, Robert P; Oscar-Berman, Marlene; Farrer, Lindsay A; Korczyn, Amos; Baldwin, Clinton T (Dove Medical Press, 2005)
    The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer's disease (AD). This study investigated whether the ACE gene ...
  • Bureau, Alexandre; Dupuis, Josée; Hayward, Brooke; Falls, Kathleen; Van Eerdewegh, Paul (BioMed Central, 2003-12-31)
    Random Forest is a prediction technique based on growing trees on bootstrap samples of data, in conjunction with a random selection of explanatory variables to define the best split at each node. In the case of a quantitative ...
  • Webster, Thomas; Vieira, Verónica; Weinberg, Janice; Aschengrau, Ann (BioMed Central, 2006-6-9)
    BACKGROUND. Mapping spatial distributions of disease occurrence and risk can serve as a useful tool for identifying exposures of public health concern. Disease registry data are often mapped by town or county of diagnosis ...
  • Cole, J Alexander; Rothman, Kenneth J; Cabral, Howard J; Zhang, Yuqing; Farraye, Francis A (BioMed Central, 2006-9-28)
    BACKGROUND. Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people ...
  • Young, Robin L; Weinberg, Janice; Vieira, Verónica; Aschengrau, Ann; Webster, Thomas F (BioMed Central, 2010-7-9)
    BACKGROUND. It is unclear whether the socioeconomic status (SES) of the community of residence has a substantial association with infant birth weight. We used multilevel models to examine associations of birth weight with ...
  • Yip, Agustín G; Green, Robert C; Huyck, Matthew; Cupples, L Adrienne; Farrer, Lindsay A (BioMed Central, 2005-1-12)
    BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) use may protect against Alzheimer's disease (AD) risk. We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-ε4 ...
  • Heard-Costa, Nancy L.; Zillikens, M. Carola; Monda, Keri L.; Johansson, Åsa; Harris, Tamara B.; Fu, Mao; Haritunians, Talin; Feitosa, Mary F.; Aspelund, Thor; Eiriksdottir, Gudny; Garcia, Melissa; Launer, Lenore J.; Smith, Albert V.; Mitchell, Braxton D.; McArdle, Patrick F.; Shuldiner, Alan R.; Bielinski, Suzette J.; Boerwinkle, Eric; Brancati, Fred; Demerath, Ellen W.; Pankow, James S.; Arnold, Alice M.; Chen, Yii-Der Ida; Glazer, Nicole L.; McKnight, Barbara; Psaty, Bruce M.; Rotter, Jerome I.; Amin, Najaf; Campbell, Harry; Gyllensten, Ulf; Pattaro, Cristian; Pramstaller, Peter P.; Rudan, Igor; Struchalin, Maksim; Vitart, Veronique; Gao, Xiaoyi; Kraja, Aldi; Province, Michael A.; Zhang, Qunyuan; Atwood, Larry D.; Dupuis, Josée; Hirschhorn, Joel N.; Jaquish, Cashell E.; O'Donnell, Christopher J.; Vasan, Ramachandran S.; White, Charles C.; Aulchenko, Yurii S.; Estrada, Karol; Hofman, Albert; Rivadeneira, Fernando; Uitterlinden, André G.; Witteman, Jacqueline C. M.; Oostra, Ben A.; Kaplan, Robert C.; Gudnason, Vilmundur; O'Connell, Jeffrey R.; Borecki, Ingrid B.; van Duijn, Cornelia M.; Cupples, L. Adrienne; Fox, Caroline S.; North, Kari E. (Public Library of Science, 2009-6-26)
    Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist ...
  • Kimura, Masayuki; Cherkas, Lynn F; Kato, Bernet S; Demissie, Serkalem; Hjelmborg, Jacob B; Brimacombe, Michael; Cupples, Adrienne; Hunkin, Janice L; Gardner, Jefferey P; Lu, Xiaobin; Cao, Xiaojian; Sastrasinh, Malinee; Province, Michael A; Hunt, Steven C; Christensen, Kaare; Levy, Daniel; Spector, Tim D; Aviv, Abraham (Public Library of Science, 2008-2-15)
    Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We ...

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