Browsing Department of Biostatistics by Issue Date

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Browsing Department of Biostatistics by Issue Date

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  • Genome-Wide Significance for a Modifier of Age at Neurological Onset in Huntington's Disease at 6q23-24: The HD MAPS Study
    Li, Jian-Liang; Hayden, Michael R; Warby, Simon C; Durr, Alexandra; Morrison, Patrick J; Nance, Martha; Ross, Christopher A; Margolis, Russell L; Rosenblatt, Adam; Squitieri, Ferdinando; Frati, Luigi; Gómez-Tortosa, Estrella; García, Carmen Ayuso; Suchowersky, Oksana; Klimek, Mary Lou; Trent, Ronald JA; McCusker, Elizabeth; Novelletto, Andrea; Frontali, Marina; Paulsen, Jane S; Jones, Randi; Ashizawa, Tetsuo; Lazzarini, Alice; Wheeler, Vanessa C; Prakash, Ranjana; Xu, Gang; Djoussé, Luc; Mysore, Jayalakshmi Srinidhi; Gillis, Tammy; Hakky, Michael; Cupples, L Adrienne; Saint-Hilaire, Marie H; Cha, Jang-Ho J; Hersch, Steven M; Penney, John B; Harrison, Madaline B; Perlman, Susan L; Zanko, Andrea; Abramson, Ruth K; Lechich, Anthony J; Duckett, Ayana; Marder, Karen; Conneally, P Michael; Gusella, James F; MacDonald, Marcy E; Myers, Richard H (BioMed Central, 2006-8-17)
    BACKGROUND: Age at onset of Huntington's disease (HD) is correlated with the size of the abnormal CAG repeat expansion in the HD gene; however, several studies have indicated that other genetic factors also contribute to ...
  • Migraine, Fibromyalgia, and Depression among People with IBS: A Prevalence Study
    Cole, J Alexander; Rothman, Kenneth J; Cabral, Howard J; Zhang, Yuqing; Farraye, Francis A (BioMed Central, 2006-9-28)
    BACKGROUND. Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people ...
  • Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Lunetta, Kathryn; D'Agostino, Ralph; Karasik, David; Benjamin, Emelia; Guo, Chao-Yu; Govindaraju, Raju; Kiel, Douglas; Kelly-Hayes, Margaret; Massaro, Joseph; Pencina, Michael; et al. (2007)
    BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS:We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for ...
  • A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Kathiresan, Sekar; Manning, Alisa; Demissie, Serkalem; D'Agostino, Ralph; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Burtt, Noel; Melander, Olle; Orho-Melander, Marju; et al. (2007)
    BACKGROUND:Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-wide association is a ...
  • Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Kiel, Douglas; Demissie, Serkalem; Dupuis, Josee; Lunetta, Kathryn; Murabito, Joanne; Karasik, David (2007)
    BACKGROUND:Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies ...
  • Reversible and Permanent Effects of Tobacco Smoke Exposure on Airway Epithelial Gene Expression
    Beane, Jennifer; Sebastiani, Paola; Liu, Gang; Brody, Jerome S; Lenburg, Marc E; Spira, Avrum (BioMed Central, 2007-09-25)
    Oligonucleotide microarray analysis revealed 175 genes that are differentially expressed in large airway epithelial cells of people who currently smoke compared with those who never smoked, with 28 classified as irreversible, ...
  • Effect of Spatial Resolution on Cluster Detection: A Simulation Study
    Ozonoff, Al; Jeffery, Caroline; Manjourides, Justin; White, Laura Forsberg; Pagano, Marcello (BioMed Central, 2007-11-27)
    BACKGROUND. Aggregation of spatial data is intended to protect privacy, but some effects of aggregation on spatial methods have not yet been quantified. METHODS. We generated 3,000 spatial data sets and evaluated power of ...
  • Treating Homeless Opioid Dependent Patients with Buprenorphine in an Office-Based Setting
    Alford, Daniel P.; LaBelle, Colleen T.; Richardson, Jessica M.; O'Connell, James J.; Hohl, Carole A.; Cheng, Debbie M.; Samet, Jeffrey H. (Springer-Verlag, 2007-1-17)
    CONTEXT Although office-based opioid treatment with buprenorphine (OBOT-B) has been successfully implemented in primary care settings in the US, its use has not been reported in homeless patients. OBJECTIVE To characterize ...
  • Handling Linkage Disequilibrium in Linkage Analysis Using Dense Single-Nucleotide Polymorphisms
    Cho, Kelly; Yang, Qiong; Dupuis, Josée (BioMed Central, 2007-12-18)
    The presence of linkage disequilibrium violates the underlying assumption of linkage equilibrium in most traditional multipoint linkage approaches. Studies have shown that such violation leads to bias in qualitative trait ...
  • Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci
    Cordell, Heather J; de Andrade, Mariza; Babron, Marie-Claude; Bartlett, Christopher W; Beyene, Joseph; Bickeböller, Heike; Culverhouse, Robert; Cupples, L Adrienne; Daw, E Warwick; Dupuis, Josée; Falk, Catherine T; Ghosh, Saurabh; Goddard, Katrina A; Goode, Ellen L; Hauser, Elizabeth R; Martin, Lisa J; Martinez, Maria; North, Kari E; Saccone, Nancy L; Schmidt, Silke; Tapper, William; Thomas, Duncan; Tritchler, David; Vieland, Veronica J; Wijsman, Ellen M; Wilcox, Marsha A; Witte, John S; Yang, Qiong; Ziegler, Andreas; Almasy, Laura; MacCluer, Jean W (BioMed Central, 2007-12-18)
  • Joint Modeling of Linkage and Association Using Affected Sib-Pair Data
    Chen, Ming-Huei; Cui, Jing; Guo, Chao-Yu; Cupples, L Adrienne; Van Eerdewegh, Paul; Dupuis, Josée; Yang, Qiong (BioMed Central, 2007-12-18)
    There has been a growing interest in developing strategies for identifying single-nucleotide polymorphisms (SNPs) that explain a linkage signal by joint modeling of linkage and association. We compare several existing ...
  • Two-Stage Approach for Identifying Single-Nucleotide Polymorphisms Associated with Rheumatoid Arthritis Using Random Forests and Bayesian Networks
    Meng, Yan; Yang, Qiong; Cuenco, Karen T; Cupples, L Adrienne; DeStefano, Anita L; Lunetta, Kathryn L (BioMed Central, 2007-12-18)
    We used the simulated data set from Genetic Analysis Workshop 15 Problem 3 to assess a two-stage approach for identifying single-nucleotide polymorphisms (SNPs) associated with rheumatoid arthritis (RA). In the first stage, ...
  • Bayesian Approaches to Reverse Engineer Cellular Systems: A Simulation Study on Nonlinear Gaussian Networks
    Ferrazzi, Fulvia; Sebastiani, Paola; Ramoni, Marco F; Bellazzi, Riccardo (BioMed Central, 2007-5-24)
    BACKGROUND. Reverse engineering cellular networks is currently one of the most challenging problems in systems biology. Dynamic Bayesian networks (DBNs) seem to be particularly suitable for inferring relationships between ...
  • Implications of Cannabis Use and Heavy Alcohol Use on HIV Drug Risk Behaviors in Russian Heroin Users
    Walley, Alexander Y.; Krupitsky, Evgeny M.; Cheng, Debbie M.; Raj, Anita; Edwards, Erika M.; Bridden, Carly; Egorova, Valentina Y.; Zvartau, Edwin E.; Woody, George E.; Samet, Jeffrey H. (Springer US, 2007-5-9)
    Cannabis and heavy alcohol use potentially increase HIV transmission by increasing risky drug behaviors. We studied 404 subjects entering treatment for heroin dependence, in St. Petersburg, Russia. We used the HIV Risk ...
  • Automated Inter-Rater Reliability Assessment and Electronic Data Collection in a Multi-Center Breast Cancer Study
    Thwin, Soe Soe; Clough-Gorr, Kerri M; McCarty, Maribet C; Lash, Timothy L; Alford, Sharon H; Buist, Diana SM; Enger, Shelley M; Field, Terry S; Frost, Floyd; Wei, Feifei; Silliman, Rebecca A (BioMed Central, 2007-6-18)
    BACKGROUND: The choice between paper data collection methods and electronic data collection (EDC) methods has become a key question for clinical researchers. There remains a need to examine potential benefits, efficiencies, ...
  • Bayesian Estimates of Linkage Disequilibrium
    Sebastiani, Paola; Abad-Grau, María M (BioMed Central, 2007-6-25)
    BACKGROUND: The maximum likelihood estimator of D' – a standard measure of linkage disequilibrium – is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes. RESULTS: This ...
  • Genome-Wide Association and Linkage Analyses of Hemostatic Factors and Hematological Phenotypes in the Framingham Heart Study
    Yang, Qiong; Kathiresan, Sekar; Lin, Jing-Ping; Tofler, Geoffrey H; O'Donnell, Christopher J (BioMed Central, 2007-9-19)
    BACKGROUND: Increased circulating levels of hemostatic factors as well as anemia have been associated with increased risk of cardiovascular disease (CVD). Known associations between hemostatic factors and sequence variants ...
  • A Genome-Wide Association Study For Blood Lipid Phenotypes in the Framingham Heart Study
    Kathiresan, Sekar; Manning, Alisa K; Demissie, Serkalem; D'Agostino, Ralph B; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Burtt, Nöel P; Melander, Olle; Orho-Melander, Marju; Arnett, Donna K; Peloso, Gina M; Ordovas, Jose M; Cupples, L Adrienne (BioMed Central, 2007-9-19)
    BACKGROUND: Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-wide association is a promising approach ...
  • Genome-Wide Association with Diabetes-Related Traits in the Framingham Heart Study
    Meigs, James B; Manning, Alisa K; Fox, Caroline S; Florez, Jose C; Liu, Chunyu; Cupples, L Adrienne; Dupuis, Josée (BioMed Central, 2007-9-19)
    BACKGROUND: Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants. METHODS: We used the ...
  • Genetic Correlates of Brain Aging on MRI and Cognitive Test Measures: A Genome-Wide Association and Linkage Analysis in the Framingham Study
    Seshadri, Sudha; DeStefano, Anita L; Au, Rhoda; Massaro, Joseph M; Beiser, Alexa S; Kelly-Hayes, Margaret; Kase, Carlos S; D'Agostino, Ralph B; DeCarli, Charles; Atwood, Larry D; Wolf, Philip A (BioMed Central, 2007-9-19)
    BACKGROUND: Brain magnetic resonance imaging (MRI) and cognitive tests can identify heritable endophenotypes associated with an increased risk of developing stroke, dementia and Alzheimer's disease (AD). We conducted a ...

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