Browsing Department of Biostatistics by Title

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Browsing Department of Biostatistics by Title

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  • Nonsteroidal Anti-Inflammatory Drug Use and Alzheimer's Disease Risk: The MIRAGE Study
    Yip, Agustín G; Green, Robert C; Huyck, Matthew; Cupples, L Adrienne; Farrer, Lindsay A (BioMed Central, 2005-1-12)
    BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) use may protect against Alzheimer's disease (AD) risk. We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-ε4 ...
  • NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium
    Heard-Costa, Nancy L.; Zillikens, M. Carola; Monda, Keri L.; Johansson, Åsa; Harris, Tamara B.; Fu, Mao; Haritunians, Talin; Feitosa, Mary F.; Aspelund, Thor; Eiriksdottir, Gudny; Garcia, Melissa; Launer, Lenore J.; Smith, Albert V.; Mitchell, Braxton D.; McArdle, Patrick F.; Shuldiner, Alan R.; Bielinski, Suzette J.; Boerwinkle, Eric; Brancati, Fred; Demerath, Ellen W.; Pankow, James S.; Arnold, Alice M.; Chen, Yii-Der Ida; Glazer, Nicole L.; McKnight, Barbara; Psaty, Bruce M.; Rotter, Jerome I.; Amin, Najaf; Campbell, Harry; Gyllensten, Ulf; Pattaro, Cristian; Pramstaller, Peter P.; Rudan, Igor; Struchalin, Maksim; Vitart, Veronique; Gao, Xiaoyi; Kraja, Aldi; Province, Michael A.; Zhang, Qunyuan; Atwood, Larry D.; Dupuis, Josée; Hirschhorn, Joel N.; Jaquish, Cashell E.; O'Donnell, Christopher J.; Vasan, Ramachandran S.; White, Charles C.; Aulchenko, Yurii S.; Estrada, Karol; Hofman, Albert; Rivadeneira, Fernando; Uitterlinden, André G.; Witteman, Jacqueline C. M.; Oostra, Ben A.; Kaplan, Robert C.; Gudnason, Vilmundur; O'Connell, Jeffrey R.; Borecki, Ingrid B.; van Duijn, Cornelia M.; Cupples, L. Adrienne; Fox, Caroline S.; North, Kari E. (Public Library of Science, 2009-6-26)
    Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist ...
  • Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
    Kimura, Masayuki; Cherkas, Lynn F; Kato, Bernet S; Demissie, Serkalem; Hjelmborg, Jacob B; Brimacombe, Michael; Cupples, Adrienne; Hunkin, Janice L; Gardner, Jefferey P; Lu, Xiaobin; Cao, Xiaojian; Sastrasinh, Malinee; Province, Michael A; Hunt, Steven C; Christensen, Kaare; Levy, Daniel; Spector, Tim D; Aviv, Abraham (Public Library of Science, 2008-2-15)
    Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We ...
  • Patterns of Abdominal Fat Distribution
    Pou, Karla M.; Massaro, Joseph M.; Hoffmann, Udo; Lieb, Kathrin; Vasan, Ramachandran S.; O'Donnell, Christopher J.; Fox, Caroline S. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: The prevalence of abdominal obesity exceeds that of general obesity. We sought to determine the prevalence of abdominal subcutaneous and visceral obesity and to characterize the different patterns of fat ...
  • Patterns of Co-Expression for Protein Complexes by Size in Saccharomyces Cerevisiae
    Liu, Ching-Ti; Yuan, Shinsheng; Li, Ker-Chau (Nucleic Acids Research, 2009-2)
    Many successful functional studies by gene expression profiling in the literature have led to the perception that profile similarity is likely to imply functional association. But how true is the converse of the above ...
  • Performance of Mixed Effects Models in the Analysis of Mediated Longitudinal Data
    Blood, Emily A; Cabral, Howard; Heeren, Timothy; Cheng, Debbie M (BioMed Central, 2010-2-19)
    BACKGROUND: Linear mixed effects models (LMMs) are a common approach for analyzing longitudinal data in a variety of settings. Although LMMs may be applied to complex data structures, such as settings where mediators are ...
  • Performance of Random Forest When SNPs Are in Linkage Disequilibrium
    Meng, Yan A; Yu, Yi; Cupples, L Adrienne; Farrer, Lindsay A; Lunetta, Kathryn L (BioMed Central, 2009-3-5)
    BACKGROUND. Single nucleotide polymorphisms (SNPs) may be correlated due to linkage disequilibrium (LD). Association studies look for both direct and indirect associations with disease loci. In a Random Forest (RF) analysis, ...
  • Performance of Statistical Models to Predict Mental Health and Substance Abuse Cost
    Montez-Rath, Maria; Christiansen, Cindy L; Ettner, Susan L; Loveland, Susan; Rosen, Amy K (BioMed Central, 2006-10-26)
    BACKGROUND: Providers use risk-adjustment systems to help manage healthcare costs. Typically, ordinary least squares (OLS) models on either untransformed or log-transformed cost are used. We examine the predictive ability ...
  • Plasma Leptin Levels and Incidence of Heart Failure, Cardiovascular Disease, and Total Mortality in Elderly Individuals
    Lieb, Wolfgang; Sullivan, Lisa M.; Harris, Tamara B.; Roubenoff, Ronenn; Benjamin, Emelia J.; Levy, Daniel; Fox, Caroline S.; Wang, Thomas J.; Wilson, Peter W.; Kannel, William B.; Vasan, Ramachandran S. (American Diabetes Association, 2008-12-29)
    OBJECTIVE: Obesity predisposes individuals to congestive heart failure (CHF) and cardiovascular disease (CVD). Leptin regulates energy homeostasis, is elevated in obesity, and influences ventricular and vascular remodeling. ...
  • PleioGRiP: Pleiotropic Genetic Risk Prediction via Bayesian model search and classification
    Sebastiani, Paola; Hartley, Stephen (2012-11-16)
    The program PleioGRiP performs a genome-wide Bayesian model search to identify SNPs associated with a discrete phenotype, and uses SNPs ranked by Bayes factor to produce nested Bayesian classifiers. These classifiers can ...
  • Population-Based Rates of Revision of Primary Total Hip Arthroplasty: A Systematic Review
    Corbett, Kelly L.; Losina, Elena; Nti, Akosua A.; Prokopetz, Julian J. Z.; Katz, Jeffrey N. (Public Library of Science, 2010-10-20)
    BACKGROUND. Most research on failure leading to revision total hip arthroplasty (THA) is reported from single centers. We searched PubMed between January 2000 and August 2010 to identify population- or community-based ...
  • Power and Type I Error Rate of False Discovery Rate Approaches in Genome-Wide Association Studies
    Yang, Qiong; Cui, Jing; Chazaro, Irmarie; Cupples, L Adrienne; Demissie, Serkalem (BioMed Central, 2005-12-30)
    In genome-wide genetic studies with a large number of markers, balancing the type I error rate and power is a challenging issue. Recently proposed false discovery rate (FDR) approaches are promising solutions to this ...
  • A Power Comparison of Generalized Additive Models and the Spatial Scan Statistic in a Case-Control Setting
    Young, Robin L; Weinberg, Janice; Vieira, Verónica; Ozonoff, Al; Webster, Thomas F (2010-7-19)
    BACKGROUND. A common, important problem in spatial epidemiology is measuring and identifying variation in disease risk across a study region. In application of statistical methods, the problem has two parts. First, spatial ...
  • Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes
    Aschengrau, Ann; Weinberg, Janice; Rogers, Sarah; Gallagher, Lisa; Winter, Michael; Vieira, Veronica; Webster, Thomas; Ozonoff, David (National Institute of Environmental Health Sciences, 2008-06)
    BACKGROUND. Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES. In this retrospective cohort study we examined ...
  • Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Congenital Anomalies: A Retrospective Cohort Study
    Aschengrau, Ann; Weinberg, Janice M; Janulewicz, Patricia A; Gallagher, Lisa G; Winter, Michael R; Vieira, Veronica M; Webster, Thomas F; Ozonoff, David M (BioMed Central, 2009-9-24)
    BACKGROUND: Prior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (PCE) have shown increases in the risk of certain congenital anomalies among exposed offspring. OBJECTIVES: This ...
  • Principal-Component-Based Population Structure Adjustment in the North American Rheumatoid Arthritis Consortium Data: Impact of Single-Nucleotide Polymorphism Set and Analysis Method
    Peloso, Gina M; Timofeev, Nadia; Lunetta, Kathryn L (BioMed Central, 2009-12-15)
    Population structure occurs when a sample is composed of individuals with different ancestries and can result in excess type I error in genome-wide association studies. Genome-wide principal-component analysis (PCA) has ...
  • Prognostic Outcomes of Tall Cell Variant Papillary Thyroid Cancer: A Meta-Analysis
    Jalisi, Scharukh; Ainsworth, Tiffiny; LaValley, Michael (SAGE-Hindawi Access to Research, 2010-7-26)
    Objective. To evaluate the prognosis of tall cell variant (TCV) compared to usual variant (UV) papillary thyroid cancer by comparing disease-related mortality and recurrence data from published studies. Methods. Ovid MEDLINE ...
  • Rapid HIV Testing Program Implementation: Lessons from the Emergency Department
    Arbelaez, Christian; Block, Brian; Losina, Elena; Wright, Elizabeth A.; Reichmann, William M.; Mikulinsky, Regina; Solomon, Jessica D.; Dooley, Matthew M.; Walensky, Rochelle P. (Springer-Verlag, 2009-9-1)
    BACKGROUND. The US Centers for Disease Control and Prevention (CDC) guidelines and the World Health Organization (WHO) both recommend HIV testing in health-care settings. However, neither organization provides prescriptive ...
  • Reversible and Permanent Effects of Tobacco Smoke Exposure on Airway Epithelial Gene Expression
    Beane, Jennifer; Sebastiani, Paola; Liu, Gang; Brody, Jerome S; Lenburg, Marc E; Spira, Avrum (BioMed Central, 2007-09-25)
    Oligonucleotide microarray analysis revealed 175 genes that are differentially expressed in large airway epithelial cells of people who currently smoke compared with those who never smoked, with 28 classified as irreversible, ...
  • Risk of Parkinson's Disease after Tamoxifen Treatment
    Latourelle, Jeanne C; Dybdahl, Merete; Destefano, Anita L; Myers, Richard H; Lash, Timothy L (BioMed Central, 2010-4-12)
    BACKGROUND: Women have a reduced risk of developing Parkinson's disease (PD) compared with age-matched men. Neuro-protective effects of estrogen potentially explain this difference. Tamoxifen, commonly used in breast cancer ...

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